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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 46, No 02 (2014)" : 12 Documents clear
Serum calcium ions, ratio of calcium/ creatinine urine and bone mass density in perimenopausal and postmenopausal women Riswan Hadi Kusuma; . Windarwati; Harjo Mulyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.242 KB) | DOI: 10.19106/JMedScie004602201402

Abstract

Early diagnosis of osteoporosis is important to take early prevention and treatment. Dual energyX-ray absorbtiometry (DEXA) scan is gold standard diagnosis of osteoporosis. However, it ishigh technology and high cost. Biochemical marker using calcium could be developed for diagnosisof osteoporosis. The study was conducted to evaluate the correlation between serum calciumions level as well as urine calcium and urine creatinine (UCa/UCr) ratio and Bone Mineral Density(BMD) in perimenopausal and postmenopausal women. This was an observational study withcross-sectional design involving women aged 45-75 years who fulfilled the inclusion and exclusioncriteria. Bone Mineral Density was measured using DEXA method. Serum and urine calcium ionswere measured using ISE method, while serum and urine creatinine were determined using Jaffemethod. Ratio of UCa/UCr were then calculated. The correlation between serum calcium ions aswell as the ratio UCa/UCr and BMD of subjects were then analyzed. A total 63 subjects wereinvolved in this study consists of 21 normal subjects, 22 subjects with osteopenia and 20subjects with osteoporosis. Negative correlation between BMD and age (r=-0.591; p=0.001)and positive correlation between BMD and body mass index (BMI) (r=0.432; p=0.001) wereobserved. No correlation between serum calcium ions and BMD (r= -0.145; p=0.258), howevernegative correlation between UCa/UCr ratio and BMD (r=-0.310; p=0.013) were reported.Furthermore, no correlation was found between serum calcium ions and lumbar BMD (r=0.036;p=0.778), while negative correlation was found between UCa/UCr ratio and lumbar BMD (r= -0.414; p=0.001). In conclusion, there is no correlation between serum calcium ions levels andBMD, however there is a weak negative correlation between UCa/UCr ratio and BMD
Optimal time of administration of fentanyl in reducing hemodynamic response in endotracheal intubation Guntur Muhammad Taqwin; Gusti Ngurah Artika; Sri Rahardjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.348 KB) | DOI: 10.19106/JMedScie004602201404

Abstract

Laryngoscopy and endotracheal intubations are frequently conducted in general anesthesia.However, it can stimulate symphatic and sympatoadrenal activities. Several non andpharmacological interventions have been used to reduce the symphatic stimulation. Fentanyl isone of the opioid drugs that frequently used to decrease the cardiovascular responses after theintubations. In order to obtain an optimal effect, fentanyl should be administered in appropriatetime. This study was conducted to compare the time of fentanyl administration at 2, 5 and 7minutes before endotracheal intubation to reduce hemodynamic responses. This was anobervational study with a prospective cohort design on patients who were going to undergoelective sugical using general anesthesia followed laryngoscopy intubation in Dr Sardjito GeneralHospital and met the inclusion and exclusion criteria. The patients were then divided into 3groups i.e patients who received fentanyl 1.5 μg/kg body weight (BW) intravenously (IV) 2minutes (Group A), 5 minutes (Group B) and 7 minutes (Group C) before laryngoscopy intubations.The hemodynmic responses including sistolic and diastolic blood pressure (SBP and DBP), meanarterial pressure (MAP), heart rate (HR) and rate pressure product (RPP) were monitored andrecorded every 1 minute during 7 minutes period. The result showed that fentanyl administration5 minutes before laryngeal intubation was more effective in the decrease hemodynamic responsethat those 2 and 7 minutes. Significantly different in SBP in 2, 3, 4 and 7 minutes observationswas observed (p<0.05). Furthermore, significantly different in MAP in 2, 3 and 4 minutesobservation and in RPP in 1, 2, 3, 4 and 7 minute observation were also observed (p<0.05). Nosignificantly different was observed in HR during observation (p>0.05). In conclusion, theadministration of fentanyl 1.5 μg/kg BW IV at 5 minutes before intubation is more effectiveagainst hemodynamic responses in endotracheal intubation.

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