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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 46, No 04 (2014)" : 12 Documents clear
Drinking water quality analysis after 22 deaths in LaeMaromas, North Sumatera Abraham Simatupang; Seruni Kusuma Udyaningsih Freisleben; Maruli Pandjaitan; Christel Westerhausen; Hans Joachim Freisleben
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 04 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.022 KB) | DOI: 10.19106/JMedScie004604201406

Abstract

The case of 22 deaths in LaeMaromas, North Sumatera suspected due to water contamination bynearby metal mining was brought by local citizens to the Church-supported non-governmentalorganization (NGO) Persekutuan Diakonia Pelangi Kasih (PDPK). The patients’ clinical symptomswere fever, shivering, shaking chills, abdominal pain, diarrhoea, and vomiting. In June 2011, ateam from the District Health Department analysed the drinking water quality, especiallymicrobiological contamination. Members of PDPK asked the German-Indonesian MedicalAssociation to conduct a second complete water analysis with focus on heavy metal content.Six water samples from four different wells in LaeMaromas and two from Sopokomil and Bongkaraswere analysed according to international water quality standards. Taste, odour, colour, and turbiditywere determined by organoleptic and photometric methods. Temperature and pH were measuredwith a calibrated thermometer and pH-meter. Total dissolved solids were determined gravimetrically,hardness as CaCO3 content. Inorganic anions and nitrogen compounds were measured by titration.Contamination with Eschericia coli and coliform bacteria, organic compounds and detergents wasdetermined according to standard methods. Heavy metals were measured by atomic absorptionspectroscopy. The pH of the water (4.5-6.5) was below standard (6.5-8.5). Heavy metals werewithin the allowed concentrations. All samples from LaeMaromas contained high counts coliformbacteria /E. coli with a peak of 1600 counts/100 mL and high organic compound level of 63 mg/Lin LaeMaromas III. Most probably, the 22 deaths were caused by drinking water contamination withcoliform bacteria rather than by heavy metals or other chemicals.
Antimicrobial activity of bioactive compounds isolated from Swietenia mahagoni (L) Jacq. against Staphylococcus aureus and Pseudomonas aeruginosa Handry Darussalam,; Titik Nuryastuti; . Mursiti; . Mustofa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 04 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.331 KB) | DOI: 10.19106/JMedScie004604201402

Abstract

Widespread bacterial resistance has led to more difficult to treat infectious diseases with availableantibiotics. Therefore, new antibiotics are needed face of the growing antibiotic resistance. Swieteniamahagoni (L.) Jacq. is one of potential medicinal plants as a source new antibiotics. Five compoundshave been isolated from an ethanolic extract of S. mahagoni (L.) Jacq., however its antimicrobialactivity has not been investigated, yet. This study was conducted to evaluate the antimicrobialactivity of these compounds. Minimal Inhibitory Concentration (MIC) and Minimal BactericidalConcentration (MBC) were determined against Staphylococcus aureus and Pseudomonas aeruginosastrains. Among five compounds tested, compound 3 (3,4,5,6,7-pentaethyl-1-methoxy-1H-indazole)and compound 4 (5-ethyl-6-methoxymethyl-2-methyl-1,2-dihydropyridine) were found to be activeagainst the bactrial strains tested with the MICs and MBCs values ranged from 50 to 100 μg/mL. Inconclusion, among five compounds isolated from S. mahagoni (L.) Jacq., compound 3 and 4showed moderate antimicrobial activity against S. aureus and P. aeruginosa strains.

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