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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 13 Documents
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Search results for , issue "Vol. 10 No. 2 (2001): April-June" : 13 Documents clear
Acute mountain sickness
Medical Journal of Indonesia Vol. 10 No. 2 (2001): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i2.19

Abstract

Acute mountain sickness, HAPE (high altitude pulmonary edema) and HACE (high altitude cerebral edema) are associated with acute exposure to altitudes greater than 8000 ft. Although usually self limiting, they can be life threatening. We are not yet clear abour the pathophysiological processes in acute mountain sickness. Descent to lower elevation is the definitive treatment for altitude illness. There is no unanimity of opinion regarding other modes of therapy. Treatment consists of bed rest, orygen inhalation and judicious use of morphine, diuretics, steroids and niftdipine as vasodilator therapy. (Med J Indones 2001; 10: 115-20) Keywords: Acute mountain sickness, high altitude pulmonary edema, high altitude cerebral edema
Mechanism of normal menstruation and abnormality associated with menorrhagia
Medical Journal of Indonesia Vol. 10 No. 2 (2001): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i2.20

Abstract

Normal menstruation involves endometrial tissue breakdown and bleeding, followed by hemostasis and repair. Abnormality of this process at any stage may result in changes in the quantity of menstrual blood loss. When menstrual blood loss is greater than 80 ml, it is called menorrhagia. This review discuss the mechanism of normal menstruation, and factors associated with menorrhagia. Those factors are the endometrial bleeding associated factor (ebaf), the role of various cells (migratory leucocytes, macrophages, and mast cells), the role of various substances (lysosomal enzymes, prostaglandins, endothelins, growth factors and its receptors), impairment of fibrinolysis and hemostatic proces, and changes in endometrial blood flow. (Med J Indones 2001; 10: 121-6) Keywords : ebaf, prostaglandin, endothelin, fibrinolysis
The aging male project
Medical Journal of Indonesia Vol. 10 No. 2 (2001): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i2.21

Abstract

With an increasing life expectancy and a decreasing reproduction rate, the population structure changes. A Jenapharm R & D program investigates the endocrinology of aging men. In men, a decrease in production of sex steroids and other hormones with age can be observed. The typical patterns of daily rhythmicity become less distinct. This is part of a very complex picture in which not only isolated hormones are involved, but also the influence of hormones on each other. Many factors from the external and intemal environment mediated by neurotransmitters constantly affect the highly sensitive hormonal balance. Therefore, aging has also been defined as "the gradual dysfunction of homeostatic processes". Declining testosterone (T) levels are involved in 'andropausal' symptoms in men: loss of libido, erectile dysfunction, insulin receptor resistance, obesity, osteoporosis, disturbances of lipid metabolism, myocardial and circulatory disturbances, impaired well-being and mood. Data are derived from studies in hypogonadal men treated by T replacement. In such parients under T treatment libido increases, fat mass decreases, muscle strenth, bone mineral density and erythropoesis increase. Whether the symptoms of andropause in aging men could successfully be treated by T substitution remains to be investigated. Negative effects of T, especially on the prostate and the cardiovascular system, are under discussion. There is increasing evidence that low T levels seem to be a risk factor for both the prostate and the cardiovascular system. Jenapharm's new testosterone undecanoate formulation for intramuscular injection can be administered every three months. T levels remain within the physiologic range. No supraphysiologic peaks occur. In women, estrogens have beneficial non-genital effects. Studies concentrate on synthetic estrogens for men without feminizing properties such as gynecomastia and reduced testicular size. Several derivatives of 17- alpha estradiol have been synthesized some of which show selectivity for the central nervous system. CNS effects have been demonstrated in female and male animals. Cardiovascular protection by estrogens has been shown in animal and human studies. Atherosclerotic plaque size was reduced after estrogen injections in cholesterol-fed rabbits. Phytoestrogen-fed monkeys had lower total cholesterol and LDL cholesterol and higher HDL cholesterol. Apart from atherosclerotic lesions, coronary artery vascular reactivity was improved. Some of these experimental findings were confirmed in human studies in postmenopausal women with and without estrogen treatment. Whether all of the described estrogenic effects can be seen in men remains to be investigated. (Med J Indones 2001; 10: 127-33)Keywords : aging, andropause, testosterone, estrogens

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