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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 12 Documents
 1   2 
Search results for , issue "Vol. 10 No. 3 (2001): July-September" : 12 Documents clear
Testes biopsy analysis and hormonal reproduction levels of pig tail macaque (Macaca nemestrina) injected with testosterone enanthate (TE) and depot medroxy progesterone acetate (DMPA)
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.22

Abstract

The objective of this study is to analyse the testes biopsy and to know the lnrmone level reproduction of pig tail macaque (Macaca nemestrina) injected with testosterone enanthate (TE) and depot medroxyprogesterone acetate (DMPA). Six pig tail male macaques, age 6 - 8 years old were used as sanrple. Three months after adaptation period, each animal was injected intra muscularly with 32 mg TE each week starting at week zero up to the sixth week. The treatment was continued every 3 weeks after the sixth week up to the 24th week. 40 mg of DMPA was injected intramuscularly at week zero, and continued every week up to week 18. Volume of the testes was taken every three weeks and blood samples for examination of gonadotropin hormone and steroid hormone were taken at 6 week intervals. Testes biopsy was perfomed at week 30 and week 48. Preparation of testes histological slides were made using the paraffin method and stained with hematoxylin-Eosin (HE). The results of this study showed that both testes volume decreased i.e. 18.35 cm3 ± 9.35 and 19.02cm3 ± 10.88 (at week zero) to 6.70 cm3 ± 3.80 and 7.02 cm3 ± 4.61 (lowest volume at week 21). In recovery period, the testes volume increased to 20.34 cmr ± 7.87 and 21.75 cm3 ± 7.09. The diameter of the seminiferous tubules and the score of spermatogenesis (right and left testes) at week 30 were 0.13 mm ± 0.027 and 0.13 mm ± 0.026 and score were 5.08 ± 2.67 and 5.41 ± 2.51. At week 48, both diameter of seminiferous tubules and spermatogenesis score increased to become 0.18 mm ± 0.029 and 0.18 mm ± 0.026, and score were 7.51 ± 2.14 and 7.57 ± 1.59, During this period, hyalinization and fibrosis of seminiferous tubule occurred. By week 6, the total testosterone, free testosterone, and estrogen hormone levels increased quite sharply and then decreased but still higher than base levels of hormone. In the recovery period, estrogen hormone increased significantly until the end of observation (week 48). FSH and LH hormone levels decreased until week 6, then the FSH hormone levels increased until the end of observation, while the LH hormone level is still lower than base level. Conclusion of this study is the injection of TE and DMPA combination will alter the histological structure of the pig tailed macaque testes i.e. decreasing the diameter of the seminiferous tubules, suppressing spermatogenesis and hyalinisation and fibrosis of seminiferous tubules. The damages of this structure are likely caused by inhibition of feedback mechanism of hypothalamus-hypophysis-testes. (Med J Indones 2007; 10: 137-43)
Identification of C5+ extraband of butyrylcholinesterase and two protein bands cathodic to it
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.23

Abstract

Electrophoresis of human plasma yields 4 butyrylcholinesterase (BChE) protein bands, i.e. C1, C2, C3, C4 and in some individuals also an extraband C5+. In addition to that other protein bands called "S" bands are also invariably detected. In order to know whether the C5+ and the "S" bands are related to the BChE protein, we have carried out immunological and peptide mapping studies on these proteins. The immunology approach was done by raising polyclonal antibodies against each protein bands (S1, S2, C4 and C5+) and reacted to the plasma protein bands transferred on nitrocellulose papers. Individual raised antibodies recognized all protein bands studied including the C4, an isozyme of BChE, indicating that the protein bands contain similar epitopes. Several protein bands cathodic to S1 also reacted with the antibodies, suggesting that they are probably fractions of the BChE protein, as well. When individual protein bands were digested with S. aureus V8 toxin and α-chymotrypsin, they revealed a striking similarity in peptide pattern among each other. These studies indicate that the S1, S2 and C5+ protein bands belong to the BChE protein. (Med J Indones 2001; 10: 144-9) Keywords: , ,
Influence of protein kinase C inhibitor in phagocytosis activity toward Candida sp
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.24

Abstract

Protein kinase C isoenzyme family that expresses in all of cells plays a pivotal role in the signal transduction pathway of a variety of hormones, cytokines, neurotransmitter, and growth factors. The immunity against Candida sp is mainly mediated and performed by the T cells and macrophages. The objective of this experiment is to know the influence the protein kinase C inhibitor - bisindolylmaleimides in phagocytosis activity toward Candida sp. The culture of peritoneal macrophage derived from BALB/c mice are treated with bisindolylmaleimides as a protein kinase C inhibitor concentration varied from 5 ng/ml to 100 ng/ml for as long as 1 minute. Then the Candida sp added is observed after every 30 minute for as long as 120 minute. As the experimental design is used themethod of factorial and orthogonal polynomial. The data consisting the length of pseudopodia and the number of Candida sp which are phagocytosed are analyzed applying the Anova. One Way Anova to show the differences of each manipulation, the Two Way Anova to show the interaction of manipulations and the Student's t Test to show the differences with control. Statistical test show significant differences on the length of pseudopodia, and phagocytosed Candida sp, at different bisindolylmaleimides concentration (p<0.001) and different observed time (p<0.001). The data show a significant interaction between the bisindolylmaleimides concentration and observed time (p<0.001). The higher the bisindolylmaleimides concentration, the earlier the observed time, the much number the protein kinase C are going inactive and the shorter the length of pseudopodia or the lower the macrophages phagocytic activity toward Candida sp. The result of this experiment indicates that bisindolylmaleimides can inhibit the macrophage mobility and phagocytic activity toward Candida sp. Further experiment in protein kinase C, especially in macrophage, is suggested. (Med J Indones 2001; 10: 150-7)
Study of genetic diversity of Salmonella typhi using pulsed-field gel electrophoresis
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.25

Abstract

DNA genomes of Salmonella typhi (S. typhi), which were isolated from sporadic typhoid fever cases who were hospitalized in Persahabatan Hospital, Jakarta, during the 1st semester of 1998, were examined for their genetic diversities. Pulsed-field gel electrophoresis (PFGE) of genomic DNA digested with Xbal was performed for 25 isolates. Electrophoresis patterns of most isolates varied and 18 PFGE types were identified. Cluster analysis showed that all isolates originated from two main groups; and at ≥84% level of similarity, 7 clusters were found. Thus, the results showed that genetic diversity of S. typhi was considerably high, and that S. typhi isolated from sporadic typhoid fever cases were derived from multiple clones. (Med J Indones 2001; 10: 158-63)
Assessment of utility of Siriraj Stroke Score (SSS) in stroke patients of Pt. BD Sharma PGIMS hospital, Rohtak, India
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.26

Abstract

India has predominantly poor rural population where brain CT scan, most often advised investigation in patients of stroke, may not always be available, hence Indian physician in such setting base his diagnosis on bed side sign evaluation for which Siriraj Stroke Score (SSS) could be helpful. Objective of study: to assess the utility of SSS in patients of stroke. Methodology: sixty subjects of stroke were evaluated on SSS and 'probable' diagnosis so made was compared with CT scan's (brain) 'certain' diagnosis. Main findings: by using SSS, the probable bedside diagnosis was cerebral infarct (score < -1) in 32 subjects and cerebral haemorrhage (score > +1) in 24 subjects while 4 subjects had indeterminant score (-1 to +1). Fifty subjects had their probable diagnosis matched with brain CT scan certain diagnosis. The above findings showed that SSS had 93.7% sensitivity, 76.6% specificity, 81.2% positive predictive value, 92% negative predictive value with an overall accuracy as 93.7% for diagnosis of cerebral infarction. For patients of cerebral haemorrhage the sensitivity was 83.3%, specificity was 92.5%, positive predictive value was 86.9%, negative predictive values was 92.5% with overall accuracy as 83.3%. Principal conclusion: physicians in the rural settings may find SSS to be quite useful in the management of stroke especially where more sophisticated radiological investigations may not be available for confirmation of diagnosis due to high cost or attended due to transportation risk. (Med J Indones 2007; 10: 164-8)
Traumatic hemipelvectomy (amputae): Report of one case
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.27

Abstract

Traumatic hemipelvectomy (amputae) is a catastrophic injury resulting front violent shearing forces which avulsed the lower limb at the level sacroiliac joint and symphisis pubis. Patients surviving traumatic hemipelvectomy are rare. One case of a 25 months old girl surviving traumatic hemipelvectomy), is presented. This is the first case reported from Indonesia. (Med J Indones 2001; 10: 169-73)
The prevalence of Strongyloides stercoralis infection in rural population of Bali: A preliminary study
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.28

Abstract

A cross-sectional study was carried out from March until September 1992 in 4 different geo-climatic rural villages in Bali to assess the prevalence of Strongyloides stercoralis infection related to age, gender and geo-climatic condition. The number of selected samples using multistage stratified random sampling based on age and gender was 2880. Strongyloides larvae in stool samples were identified by modified Harada Mori fecal culture technique. The results showed that the overall prevalence of Strongyloides infection was 1.6%; the prevalence in male was 1.2% and in female was 2.1%, however the gender difference was not statistically significant. In term of age, there was no statistically significant difference. The highest prevalence (2.4%) was found among 7-12 years children, followed by aged 7 years or less (1.6%), 18 years or over (1.6%), and 13-18 years (0.6%). The prevalence of Strongyloides infection related to geo-climatic conditions was significantly difference. The highest prevalence of Strongyloides infection was at wet highland (3.3%), followed by wet lowland (1.5%), dry highland (1.0%), and dry lowland (0.9%). In conclusion, the prevalence of Strongyloides stercoralis infection in Bali was very low. Prevalence of Strongyloides infection was highly related to geo-climatic type of area, but not to gender and age groups. (Med J Indones 2001; 10: 174-7)
Selective estrogen receptor modulators (SERM): A new choice for postmenopausal women and physicians who worry on cancer
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.29

Abstract

The postmenopausal state is characterized by the cessation of menstruation, loss of ovarian function, and a dramatic decrease in the level of circulating estrogen. This state of estrogen deficiency contributes to the acceleration of several age-related health problems in women, including cardiovascular disease, osteoporosis, and dementia. Estrogen replacement is clearly effective in the short-term and long-term treatment and prevention of postmenopausal symptoms. However, until now, the amount of HRT user is still very low. Fear of breast cancer and endometrial cancer are the most common concern in using hormone replacement therapy (HRT), although the relationship between long-term HRT and breast cancer remains controversial. For physicians or patients, who worry on cancer, the ideal drug is now available i.e. the selective estrogen receptor modulators (SERM), with the generic name raloxifine. (Med J Indones 2001; 10: 187-90)
Filariasis in the new millennium
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.30

Abstract

The lndonesian national filariasis eradication program in its pursuit in obtaining microfilarial rates below 1% in filariasis endemic locations was on its right track until the monetary crisis started 3 years ago. This crisis which is not over yet at present is complicated by unstable public safety causing population shifts where people from filaria endemic locations seek refuge in non-endemic areas. This updated review will hopefully serve as a timely reminder to our physicians and health workers especially on the mode of filarial transmission as well as on its clinical presentations and presently accepted ways of manaqement. This paper also will serve as an introduction into the present breakthroughs in this new millenium as noted in the field of diagnostics and simplified mass treatment schedules making it possible for the elimination of lymphatic filariasis as a public health problem. A global alliance under the guidance of the World Health Organization with support of the multinational pharmaceutical companies for providing free expensivemedication as needed. The WHO also cooperates closely with the Tropical Diseases Research task forces of Filariasis Intervention Research and of Product Development, that in the end will provide the means to eradicate this disease for once and forever from the face of the earth. (Med J Indones 2001; 10: 191-6)
Genetic risk factors for chronic obstructive pulmonary disease
Medical Journal of Indonesia Vol. 10 No. 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v10i3.31

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex condition, influenced by environmental and/or genetic risk factors. It is important to identify these factors, and develop new therapies for the management of COPD. This review identifies these factors and highlights the role they will play in future treatment options of COPD. (Med J Indones 2001; 10: 178-81)

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