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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 10 Documents
 1 
Search results for , issue "Vol. 12 No. 4 (2003): October-December" : 10 Documents clear
Clinical Manifestation of Acute Myocardial Infarction in the Elderly
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.112

Abstract

A retrospective study were performed in patients with acute myocardial infarction (AMI) that hospitalized in ICCU Cipto Mangunkusumo hospital, Jakarta during the period of January 1994 until Decmber 1999. There were 513 patients hospitalized with MCI, 227 patients (44.2%) were classified as elderly, and 35.2% of them were female. Most of the elderly AMI patients reported typical chest pain just like their younger counterparts. Elderly AMI patients tend to come later to the hospital, and more Q-wave myocardial infarction were identified compared to non- Q-wave myocardial infarction. Risk factors of diabetes mellitus and hypertension were more common among the elderly. The prevalence of atrial fibrillation and the mortality rate were higher among elderly AMI patients. (Med J Indones 2003; 12: 229-35)
Effect of Hormone Replacement Therapy (HRT) and low-dose combined oral pill on skin thickness, lipid profile and blood chemistry of menopausal women
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.113

Abstract

This study to evaluate the effect of hormone replacement therapy ( HRT ) and low-dose combinated oral pill on skin thickness , lipid profile and blood chemistry on menopausal woman.This study was carried out in one year randomized prospective study. 36 women were divided into 18 women receiving HRT and the other 18 receiving low-dose oral pill. The result of this study showed an increase in skin thickness (collagen) in both groups. But Those received low dose oral pill showed more . The increase of the skin thickness can prevent osteoporosis. The administration of HRT or low-dose oral pill could cause allteration in blood lipip profile and blood chemistry. But The changes were still within in normal limit. The administration of low-dose oral pill can be considered in postmeno-pausal women. (Med J Indones 2003; 12: 224-8)
Renal impairment in β thalassemia major patients receiving repeated blood transfusion
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.114

Abstract

β-thalassemia major is a disease caused by β polypeptide chain synthesis disorder which is inherited in an autosomal recessive manner from both parents and which is marked by little or no β-globin chain synthesis. Treatment for β-thalassemia major patients is by giving repeated blood transfusions, which causes iron accumulation, leading to hemochromatosis. Iron accumulation can occur in various body organ, including the kidneys. The aim of this study was to investigate the existence of renal impairment in β-thalassemia major patients. The subjects of this study were β-thalassemia major patients aged 15 - 28 years old who had received 6 units of packed red cells or more within 6 months. In this study, urine and serum samples of the subjects were taken and examined. Assay of serum iron was performed with Hitachi 737. Results were that 94.7% patients showed an increase in transferrin saturation and 40% of them had hemochromatosis; 73.4% had microalbuminuria; 1.3% had albuminuria and 21.3% had increased urinary β2- microglobulin (β2-m). A total of 78.6% of patients showed renal impairment. Conclusion of this study suggested that glomerular dysfunction happens in an earlier stage of the disease process. The high incidence of microalbuminuria is also attributed to defective ability of the proximal tubular cells to reabsorb protein besides dysfunction of the glomeruli. (Med J Indones 2003; 12: 215-223)
Rhabdomyolysis in Indonesian marathon athlete
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.115

Abstract

Serum and urine myoglobin assessments were conducted on 37 national marathon athletes who participated in the Asian Marathon III & Proklamaton XV. Three athletes showed a myoglobin value of < 50 ug/L and the other 34 athletes showed a myoglobin value of 211-3300 ug/L. Rhabdomyolysis were only found in 2 athletes, thus the prevalence of rhabdomyolysis is 6.1%. A correlation was found between myoglobinemia value and the athlete’s performance. (Med J Indones 2003; 12: 207-14)
The correlation between high sensitivity C-Reactive Protein level and the Extent of Coronary Lesion and Cardiac Systolic Function in Coronary Heart Disease
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.116

Abstract

To determine the mean value of high sensitivity C-Reactive Protein (hs-CRP), association between plasma level of hs-CRP with extent of disease and systolic function. A cross sectional study had been conducted to 106 coronary artery disease patients (90 stable angina pectoris, 11 unstable angina pectoris and 5 acute myocardial infarction). Plasma quantitative level of hs-CRP with cor angiography to determine extent of disease and ejection fraction were measured. The mean of hs-CRP levels in patients with SVD were 5,5 ± 7,6 mg/L, DVD were 6,6 ± 21,7 mg/L and TVD were 5,5 ± 8,0 mg/L and p=0,056, respectively. There were no significant association between hs- CRP levels with extent of disease. Systolic function had negative correlation with levels of hs-CRP (p=0,015, r=-0,235). This study showed that plasma level of hs-CRP cannot reflect the extent of disease, and it had negative correlation with systolic function. (Med J Indones 2003; 12: 201-6)
Fermentation of phytic acid from lamtoro gung seeds (Leucaena leucocephala) to produce inositol and tannin as pharmaceutical commodity
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.117

Abstract

The research was done to define the effect of tempe yeast concentration on inositol and tannin contents of fermented lamtoro gung seeds (Leucaena leucocephala). This is a research with completely randomized design using four doses of tempe yeast, i.e. 0 %, 5 %, 10 %, and 15 %. Each treatment was replicated 4 times. The resulted data were analyzed by analysis of variance and the significant differences were tested by least significantly difference test. Tannin was analyzed by Lowenthal-Procter method. The result of the research showed that the treatment had significant effects (P<0.05) on the parameter measured. The highest inositol with lowest tannin contents were found by using 15 % tempe yeast and duration of fermentation 96 hours, that is 0.2631 %. (Med J Indones 2003; 12: 236-42)
High protein and iron-folate crackers supplementation on the iron status of pregnant women
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.118

Abstract

Previous studies have revealed that several factors influenced the relatively low success of iron supplementation for pregnant women. The factors included poor distribution, low coverage and compliance, as well as low absorption. The aim of this study is to measure the iron status of pregnant women after consuming crackers containing fish powder and iron-folate. This study was carried out in the Purworejo district (Central Java) from February through October 2002. Using a randomized controlled trial (RCT) design, 70 pregnant women in their second-third month of pregnancy were recruited, and divided into two groups. Ten women dropped out during the study. The first group consisted of 28 women were given protein – iron enriched crackers (PIEC group), while the second group of 32 women were given iron–enriched crackers (IEC group) for a total of 12 weeks. The results showed that the hemoglobin (Hb) levels and serum transferrin receptors (sTfR) of both groups were increased. Serum ferritins (SF) of both groups were decreased. At the end of the study, the increase in Hb and sTfR levels between the two groups were significantly different, while the decrease in SF was not significantly different. Animal protein from fish powder tended to improve absorption of non-heme iron among pregnant women, resulting in improved Hb and sTfR levels. (Med J Indones 2003; 12: 243-6)
Malaria and Anopheles spp in the villages of Salubarana and Kadaila, Mamuju District, South Sulawesi Province, Indonesia
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.119

Abstract

Malaria epidemiology in Salubarana and Kadaila villages, Mamuju District, South Sulawesi Province, Indonesia was studied from July-December 2002 to obtain baseline data related to the parasite, mosquito vector, human host, and environmental factors. Monthly malariometric surveys conducted during the six- month period revealed a relatively high prevalence of malaria in Kadaila in comparison to Salubarana. Kadaila was mainly inhabited by migrants from Java, Bali, Lombok, and from other districts of South Sulawesi. Salubarana, on the other hand, was inhabited mainly by indigenous Mandarese. Analysis of 1,113 blood smears taken from individuals randomly involved in the survey revealed 59 positive samples, consisting of Plasmodium falciparum or P. vivax. These two species predominated the samples examined and were occasionally found as mixed infection. Anopheles barbirostris was confirmed as a vector for malaria in this area whereas 7 other species An. barbumbrosus, An. parangensis, An. vagus, An. crawfordi, An. pseudobarbirostris, An. Tessellatus, and An. subpictus should be considered as potential vectors. The first mentioned species predominated, using mainly riverbeds and ground pools as breeding places with a habit of indoor or outdoor resting. These findings could be useful for establishing evidence-based malaria control program in the area. (Med J Indones 2003; 12: 252-8)
The effects of zinc supplementation on the TNF-α profile and diarrhea in severely malnourished children of low income family
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.120

Abstract

Zinc deficiency has a great impact on growth and development, especially in malnourished children. Zinc is important in both local and systemic immunity. The aim of this study was to assess the impact of zinc supplementation on the cytokine, tumor necrosis factor α (TNF-α), and diarrhea in severely undernourished under-five children of low-income families. A randomized double blind pre-test post-test controlled design was selected. A group of 12-59 month-old children were given local food, and treated as control group (n=60), and another group (n=60) were given local food with 15 mg/5 ml zinc as intervention group. Zinc concentration was measured by atomic absorption spectrophotometer (AAS), and TNF-α concentration was determined by ELISA. Data on nutrient intakes were collected using 24-hour food recall method. The result of the study showed that after zinc intervention, zinc serum increased significantly, and TNF-α concentration decreased along with reduction of the duration and frequency of diarrhea. Zinc concentration increased 87.0% in the intervention group, while in the control group the increase was only 19.6%. There was a significant reduction of both serum and fecal TNF-α concentration after intervention (p<0.05). Severity and duration of diarrhea were reduced significantly in the intervention group compared to the control group (p<0.001). It was concluded that zinc intervention reduced the duration and severity of diarrhea through improvement of immunity, especially local immunity with TNF-α as biomarker. (Med J Indones 2003; 12: 247-51)
Molecular based detection for drug resistance in mycobacterium tuberculosis
Medical Journal of Indonesia Vol. 12 No. 4 (2003): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v12i4.121

Abstract

Multi- drug resistant tuberculosis continues to be a serious problem, particularly among some developing countries. Early detection of drug resistance in clinical M. tuberculosis isolates is crucial for appropriate treatment and to prevent the development of further resistance. Compared to conventional methods using solid media, the introduction of manual and automated methods (BACTEC or MB/BacT) for susceptibility testing in liquid media has resulted from 4 to 6 weeks to 3 to 15 days. The identification of resistance mutations, e.g., the genetic basis for RIF resistance, enables the development of molecular test that allows the detection of resistant strains within 1 day. One approach is the use of molecular analysis to detect mutations that are associated with resistance to drugs including INH and RIF. In the case of INH, mutations of the katG, inhA, kasA, and ahpC genes are responsible for the majority of INH-resistant M. tuberculosis, whereas mutations of rpoB are responsible for RIF-resistant M. tuberculosis. (Med J Indones 2003; 12: 259-65)

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