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Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 12 Documents
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Search results for , issue "Vol. 13 No. 3 (2004): July-September" : 12 Documents clear
Immunophenotyping in leukemia and its diagnostic significance
Medical Journal of Indonesia Vol. 13 No. 3 (2004): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v13i3.152

Abstract

The identification of cell surface markers, defined as clusters of differentiation antigens (CD’s) could be used to classify and sub-classify leukemia. Although the same antigens are expressed on normal cells, the phenotype on malignant cells are aberrantly and frequently asynchronously expressed and may be present in combinations not observed in normal blood or bone marrow. Aberrant expression of surface antigens corresponds with poor therapeutic response and short survival. Additional surface marker analysis complementary to morphologic evaluation and cytochemical staining has greatly improved our ability to characterize hematologic malignancies. A review and illustration on the diagnostic significance of immunophenotyping in leukemia will be presented. Data from 225 patients having complete assessments including morphology, cytochemistry and immunophenotyping in the period of 1994-2001 were collected and analyzed. Based on morphologic evaluation and cytochemistry, the diagnosis of acute myeloid leukemia and acute lymphoblastic leukemia were established in 51.1% and 48.9% of cases, respectively. Based on immunophenotyping AML was found in 49.0% of the cases. ALL could be classified into 4.9% pre-B-ALL, 18.7% B-ALL, and 14.7% T-ALL. Cases expressing cross-lineage antigens were found in 12.7%. The prognostic significance of these aberrant expression of antigens for those cases has yet to be established but some of the cases responded poorly to therapy. Immunophenotyping provides the tool to: 1) distinguish normal from clonal populations of leukemic cells; 2) define lineage and reveal the stage of maturation; 3) identify inappropriate expression of lineage associated antigens; 4) provides more informations to establish diagnosis and prognosis compared to standard methods. (Med J Indones 2004; 13: 195-202) Keywords: Immunophenotyping, clusters of differentiation antigens, lineage associated antigens
Non-lymphomatous malignancies associated with human immunodeficiency virus infected patients
Medical Journal of Indonesia Vol. 13 No. 3 (2004): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v13i3.556

Abstract

Non-lymphomatous malignancies may also develop in immunocompromised patients. However a detail study about the cases is lacking. Here we describe four cases of solid tumours in HIV seropositive patients. (Med J Indones 2004; 13: 171-2)Keywords: solid tumours, HIV infection, radiation therapy, chemotherapy

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