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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 9 Documents
 1 
Search results for , issue "Vol. 16 No. 3 (2007): July-September" : 9 Documents clear
Curcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tert-butylhydroperoxides
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.269

Abstract

Curcumin, an active ingredient of curcuma plant has been thought to be beneficial in the treatment of liver diseases. In the previous studies, we have shown the protective effects of curcumin against lipid peroxidation and swelling of the ratlivermitochondrial preparation induced by tert-butylhydroperoxide (t-BuOOH). In the present study, the administration of t-BuOOH of 90 µM caused the mitochondria failed to generate a transmembrane potential (Ym). Of 3 doses of curcumin administered (0.5µM, 2.5 µM dan 5.0 µM) the maximum protective effect against failure to generate a transmembrane potential caused by t-BuOOH was obtained by 2.5µM of curcumin(79.13+6.28%).Further, curcumin of 1000 µM could prevent protein aggregation formation caused by t-BuOOH in the electrophoretogram. This study shows the protective effects of curcumin against damaged of energy production system and protein of the mitochondria caused by t-BuOOH. (Med J Indones 2007; 16:139-45)
Study on retinol binding protein (RBP) receptor in hydatidiform mole trophoblastic cells
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.270

Abstract

Hydatidiform mole is an abnormal pregnancy characterized by the proliferation of cytotrophoblastic, syncytiotrophoblastic, and intermediate trophoblastic cells in histological specimens. Vitamin A plays a role in controlling cell proliferation, and decrease in vitamin A level will cause an uncontrollable proliferation. To date, it is not known whether there is a relationship between vitamin A deficiency and hydatidiform mole. This study aimed to demonstrate the presence of retinol binding protein (RBP) receptors in the hydatidiform mole trophoblastic cells, that would provide explanation on the relationship of vitamin A and hydatidiform mole. The study was a descriptive study. The specimens of the study were paraffin blocks of hydatidiform mole made in 2005, and the examinations were performed by indirect immunohistochemistry. We examined the distribution of the cells showing expression of RBP receptor, the strength of expression, and location of the expression. As many as 21 specimens were collected, and the distributions of RBP receptor expression in hydatidiform mole trophoblastic cells ranged from moderate to dense. The expression in syncytiotrophoblastic cells was stronger than that in cytotrophoblastic cells. Furthermore, the expressions were found in the cell membranes and cytoplasm. (Med J Indones 2007; 16:146-50)
The effect of excessive disodium ethylene diamine tetraacetic acid (Na2EDTA) anticoagulant concentration on leukocytes profile in peripheral blood examination
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.271

Abstract

Accuracy of leukocytes profile assessment is influenced by several pre analytical factors, among others, the anticoagulant concentration. EDTA is one of the most frequently used anticoagulant in peripheral blood examination. Several references stated that inappropriate concentration of EDTA anticoagulant in blood sample may affect the result of leukocytes profile in peripheral blood examination. The aim of this study was to evaluate whether there are differences among leukocytes profile in peripheral blood examination specimens, which were prepared with excessive Na2EDTA anticoagulant in different concentration. This study was conducted in Faculty of Medicine, Gadjah Mada University. Blood samples from 30 subjects were taken using vein puncture. Two millimeters blood was divided into 4 Na2EDTA-containing tubes. Before that, one drop of blood without Na2EDTA anticoagulant was used to make blood film right after vein puncture, as control. Each tubes contained different concentration of anticoagulant. The first tube contained Na2EDTA in standard concentration 2 mg/ml; the remaining tubes contained 4 mg/ml, 6 mg/ml, and 8 mg/ml respectively. These samples were immediately examined using SYSMEX SE-9500 automatic cell counter to measure the total and differential leukocytes count; and were stained with Wright staining for morphological examination under the microscope. These procedures were done before 20 minutes of vein puncture. There were significant decrement of total leukocytes count, absolute differential leukocytes count and monocyte percentage following excessive Na2EDTA administration. Neutrophil percentage was found to be relatively increased and the difference was significant. Lymphocyte, eosinophil and basophil percentages were not significantly different. Morphological examination showed significant increment in irregular cytoplasm margin, vacoulation and irregular nuclei lobes following excessive Na2EDTA administration. It is concluded that excessive concentration of Na2EDTA used in blood specimen preparation, will lead to changes in leukocytes profile as the concentration increased. Standard Na2EDTA anticoagulant concentration did not alter any leukocytes count and morphology, except for irregular cytoplasm margin and irregular nuclei lobes. (Med J Indones 2007; 16:168-75)
A comparative bioavailability study of two ibuprofen formulations after single-dose administration in healthy volunteers
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.272

Abstract

This study was aimed to investigate the bioequivalence of ibuprofen 125 mg suppository formulation (Ibukal®, test formulation from PT. Kalbe Farma, Tbk., Jakarta) and the ibuprofen suppository comparative formulation (Proris®, from PT. Pharos Indonesia, Jakarta) in 12 healthy volunteers. The pharmacokinetic parameters used in this study were the area under the concentration-time curve from time zero to hour 10 (AUC0-t), the area under the concentration-time curve from time zero to infinite (AUC0-inf), the maximum concentration (Cmax), and the time needed to reach the maximum concentration (tmax). The study was designed as a random cross-over fashion, single-blinded which included 12 healthy adult volunteers. The volunteers were fasted overnight and in the morning they received a suppository of the test drug (Ibukal®) or a suppository of the comparative drug (Proris®). Blood samples were withdrawn on hour 0 (control), 20 min; 40 min; 1; 1.5; 2; 2.5; 3; 4; 6; 8; and 10 time points after the administration of the drug. Following a wash-out period of 1 week, this procedure was repeated using the other drug. The serum concentration of the drug was determined by means of high-performance liquid chromatography with ultraviolet detection. The results of the study showed that, the mean (SD) of AUC0-t, AUC0-inf, Cmax and tmax of the test drug were, respectively, 28.59(3.37) μg.h.mL-1, 30.47(3.56) μg.h.mL-1, 8.24(1.44) μg/mL, and 1.33(0.44) h. The mean (SD) of AUC0-t, AUC0-inf, Cmax and tmax of the comparative drug were, respectively, 28.13(8.14) μg.h.mL-1, 30.56(8.05) μg.h.mL-1, 8.27(2.88) μg/mL, and 1.79(0.33) h. The geometric means ratio of the test to the comparative drug were 104.38% (CI 90%: 90.38-120.54%) for AUC0-t, 101.97% (CI 90%: 89.51-116.16%) for AUC0-inf, and 104.02% (CI 90%: 85.73-126.16%) for Cmax. There was no side effect of the drug detected in this study. From the results we can conclude that the 125 mg of ibuprofen suppository of PT Kalbe Farma, Tbk. (Ibukal®) is bioequivalent to that of the comparative drug (Proris®). (Med J Indones 2007; 16:181-6)
Efficacy and tolerability of 12-weeks treatment with lipanthyl supra or trichol in Indonesian patients with dyslipidemia
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.273

Abstract

The relation of dyslipidemia with the development and progression of atherosclerosis and coronary artery diseases has been demonstrated.This study compared the lipid modifying effects of locally-manufactured fenofibrate (trichol) versus lipanthyl supra in a randomized double-blind controlled study.A total of sixty-eight patients with levels of HDL cholesterol≤40 mg/dL; triglyceride of 200–600 mg/dL; or LDL of ≥130 mg/dL were recruited to this study and were randomized to either receive trichol 300 mg once daily or lipanthyl 160 mg once daily. Sixty one patients completed the study. Lipid levels before and 4, 8, and 12 weeks after the treatments were measured and analyzed.Compared to baseline values, 12-weeks treatment with either lipanthyl or trichol significantly increased plasma HDL by 18.8% and 14.3% respectively (P<0.001), decreased triglyceride by 38.2% and 37.2% (P<0.001), but with no significant change in LDL levels. Furthermore, we observed a decreasedin total cholesterol levels compare to baseline by 8.4%(P<0.05)and 3.1% (P=0.114), intotal cholesterol/HDL ratio by17.6% and 18.4% (P<0.001), in fibrinogen level by 13.8% and 6.4% and an increase in ApoA-1 by 15.0% and 9.7%for lipanthyl and trichol, respectively. Interestingly, the decrease in total cholesterol level is significantly higher in trichol than lipanthyl groups (P<0.05).The adverse events of both treatments were comparable.The lipid-modifying effects of 300 mg daily dose of trichol is comparable to that of 160 mg daily dose of lipanthyl. Both drugs efficiently increased the plasma HDL levels and decreased plasma triglycerides concentration. Besides, a significant reduction of total cholesterol was achieved after 12 weeks treatment with trichol, but not lipanthyl. (Med J Indones 2007; 16:159-67)
Electrophysiological characteristics and radiofrequency ablation of right atrial flutter
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.274

Abstract

This study aimed to elaborate the electrophysiology characteristics and radiofrequency ablation (RFA) results of atrial flutter (AFL) which has not been established in Indonesia. Three multipolar catheters were inserted percutaneously and positioned into coronary sinus (CS), His bundle area and around tricuspid annulus. Eight mm ablation catheter was used to make linear ablation at CTI of typical and reverse typical AFL. Bidirectional block was confirmed by conduction time prolongation of more than 90 msec from low lateral to CS ostium and vice versa, and/or by means of differential pacing. ThirtyAFL from 27 patients comprised of 19typical AFL, 5 reverse typical AFL and 6 atypical AFL enrolled the study. Mean tachycardia cycle length (TCL) were 261.8± 42.84,226.5 ± 41.23, and 195.4± 9.19msec, respectively (p = 0.016). CTI conductiontime occupied up to 60% of TCL with mean conduction time of 153.0± 67.37msec. CS activation distributed to three categories which comprised of proximal to distal, distal to proximal and fusion activation. Only nine of 27 patients had no structural heartdisease. RFA of symptomatic typical and reverse typical AFL demonstrated 96% success and 4.5 % recurrence rate during 13 ± 8 months follow up. Typical AFL is the predominant type of AFL in our population. The majority of AFL cases suffered from structuralheart disease. RFA was highly effective to cure typical and reverse typical AFL. (Med J Indones 2007; 16:151-8)
Radiological evaluation of acromial characteristic using supraspinatus outlet view in shoulder impingement syndrome
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.275

Abstract

Purpose of this study was to find the association between shoulder impingement syndrome (SIS) and morphological characteristics of acromion (acromial tilt angle, typeof acromion, subacromial osteophyte).Supraspinatus outlet view was performed using fluoroscopy. There were 40 SIS patients and 40 individuals with no shoulder pain examined and measured for their acromial tilt angle, typeof acromion (according to Bigliani’s classification and Park’s criteria) and forthe presence of subacromial osteophyte. Average acromial tilt angle was 34.1° (SD 7.6) for SIS group and 32.1° (SD 7.7) for control group. Type II acromion was found more frequent in both groups (85% and 95%). The association between SIS and acromial tiltangle or between SIS and type of acromion were statisticallyinsignificant (p=0.241 and p=0.221). Subacromial osteophyte was found in 52.5% of SIS group compare to 12.5% among the control group, and the association with SIS was statistically significant (p=0.0003).Subacromial osteophyte was found to have significant association with SIS. Such association was not found in acromial tilt angle and type of acromion. (Med J Indones 2007; 16:176-80)
Body mass index, total cholesterol, and ratio total to HDL cholesterol were determinants of metabolic syndrome in the Indonesian elderly
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.276

Abstract

Available data on metabolic syndrome amongst the aged Indonesian population are limited, despite the importance of these data for cardio vascular disease (CVD) preventive measures. The objective of this study was to assess prevalence of metabolic syndrome and the associations between anthropometric measurements, lipid profiles, blood pressure, nutrient intakes and physical activity and metabolic syndrome in the elderly. A cross-sectional study was undertaken from January to April 2000 at selected Public Health Centers in Jakarta using multistage random sampling. Data were collected through anthropometric measurements, biochemical blood analysis, nutrient intake assessment and activity index. The subjects consisted of 352 females and 137 males. Prevalence of metabolic syndrome among females was 18.2% and 6.6% in males. This study shows metabolic syndrome was associated with gender, body mass index, totalcholesterol and the ratio of total to HDL-cholesterol. Elderly who were overweight based on body mass index (BMI) had almost a four-fold increased risk for metabolic syndrome (adjusted odds ratio = 3.98; 95% confidence interval 2.23 -7.10). Those who had plasmatotal cholesterol ≥ 240 mg/dl had a 2.7 times greater risk of having metabolic syndrome than those with plasma total cholesterol < 240mg/dl. Furthermore, in terms of the ratio of total to HDL cholesterol, those who had a ratio ≥ 5 compared to a ratio < 5 had two-fold increased risk for metabolic syndrome. In conclusion, this study shows the importance of routine checks of lipid profile, blood pressureand simple anthropometric assessment to detect the risk of metabolic syndrome in the elderly.(Med J Indones 2007; 16:195-200)
The prevalence of female sexual dissatisfaction and the dominant risk factors that may impair sexual satisfaction in Malaysian women
Medical Journal of Indonesia Vol. 16 No. 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v16i3.277

Abstract

The study aims were to investigate the prevalence of sexual dissatisfaction and the potential risk factors.This was a cross-sectional study on women attending primary care setting in Malaysia over a period of March to June 2005, and used a non-probability sampling method. A validated questionnaire for sexual function was used.A total of 230 married women aged 21–62 years old participated in this study. The ressults show that the majority of the respondents were less than 45 years old, predominantly Malays, and with higher academic achievement. We noted that 52.2% (120/230) study subjects had sexual dissatisfaction. Race, salary, education level, medical problems, dysmenorrhea, and menacrhe were likely not correlated with sexual dissatisfaction. The dominant risk factor related to sexual dissatisfaction was age of husband. In additional, sexual dissatisfaction was moderately (P=0.077) related to sexual per month. The subjects who had their husbands aged 43-75 years compared with 24-42 years had 68% increased risk to experience sexual dissatisfaction [adjusted relative risk (RRa = 1.68; 95% confidence interval (CI) = 1.15 -2.44]. In term of sexual frequency per month, those who had 1-3times per month than 4-5 times per month had two-fold increased risk to experience sexual dissatisfaction (RRa = 2.03; 95% CI = 0.93-4.42; p = 0.077).In conclusion, the prevalence of sexual dissatisfaction was very high in Malaysian primary care population and it was strongly associated with women who married to an older husband and with infrequent sexual activity. (Med J Indones 2007; 16:187-94)

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