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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 11 Documents
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Search results for , issue "Vol. 23 No. 2 (2014): May" : 11 Documents clear
Effectiveness of permethrin standard and modified methods in scabies treatment
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.594

Abstract

Background: Permethrin is the drug of choice for scabies with side effects such as erythema, pain, itching and prickling sensation. Whole-body (standard) topical application of permethrin causes discomfort; thus, modified application of permethrin to the lesion only, followed with baths twice daily using soap was proposed. The objective of the study is to know the effectiveness of standard against lesion-only application of permethrin in scabies treatment. Methods: An experimental study was conducted in pesantren in East Jakarta and data was collected in May-July 2012. Diagnosis of scabies was made through anamnesis and skin examination. Subjects positive for scabies were divided into three groups: one standard method group (whole-body topical application) and two modified groups (lesion-only application followed by the use of regular soap and antiseptic soap group). The three groups were evaluated weekly for three consecutive weeks. Data was processed using SPSS 20 and analyzed by Kruskal-Wallis test. Results: Total of 94 subjects was scabies positive (prevalence 50%) but only 69 subjects were randomly picked to be analyzed. The cure rate at the end of week III of the standard method group was 95.7%, modified treatment followed by the use of regular soap was 91.3%, and modified treatment followed by the use of antiseptic soap was 78.3% (p = 0.163). The recurrence rate of standard treatment was 8.7%, modified treatment followed by the use of regular soap was 13% and modified treatment followed by the use of antiseptic soap was 26.1% (p = 0.250). Conclusion: The standard scabies treatment was as effective as the modified scabies treatment.
The social determinants of knowledge and perception on pulmonary tuberculosis among females in Jakarta, Indonesia
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.651

Abstract

Background: Indonesia has not resolved tuberculosis burden since its prevalence and incidence has remained high. As the capital of Indonesia with a large population and a high number of tuberculosis cases, Jakarta has a distinctive condition of tuberculosis burden. This study aimed to obtain social determinants of knowledge and perception of pulmonary tuberculosis in an urban community. Methods: This study used 2,323 samples taken by random sampling in Jakarta during February-May 2011. Questionnaires were delivered to assess respondents’ knowledge and perception about pulmonary tuberculosis. Levels of knowledge were categorized into ‘poor’ and ‘good’. Perceptions about tuberculosis were measured by whether respondents perceived tuberculosis as a humiliating disease and a shunned disease. Results: Most respondents (88.7%) had good level of knowledge about tuberculosis, but misperception remained high (45.9%) in the community. Education level determined level of knowledge. The higher the education level the lower the risk of lack of knowledge. Tuberculosis perceptions were determined by family income and education level. Higher family income and education level were protective factors of misperception about tuberculosis as a humiliating disease and tendency to shun tuberculosis patients. Conclusion: People in urban area of Jakarta have good level of knowledge about tuberculosis, but it does not necessarily lead to proper perception of tuberculosis. Age, education level and having health insurance determined level of knowledge, while tuberculosis perceptions were determined much more by education level and family income. Tuberculosis control program should consider these determinants prior to developing a comprehensive strategy.
Cost of hemodialysis after coverage by national health insurance in Japan: a sharing experience with Indonesian health reform system
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.652

Abstract

About 50 years ago, Japan established a health insurance system covering the entire population, and started a period of rapid economic growth, similar to what is happening now in Indonesia. Although improvements in health conditions definitely contributed to the development of modern Japan, the costs of medical care became a serious burden on the economy. In this short report, we review the concept of medical care expenditure in Japan, focusing especially on end-stage renal disease, to provide suggestions to medical reform in Indonesia.
Case report of secondary hypertension due to renal artery stenosis in young patient
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.666

Abstract

Secondary hypertension is rare to occur, but should become suspicion in young age. Secondary hypertension must be appropriately diagnosed and treated. Renal artery stenosis is one of many causes of secondary hypertension. The aim of this case report is to describe diagnosis, pathophysiology and management of secondary hypertension due to renal artery stenosis in young patient. A 17 year old man with symptom of shortness of breath was diagnosed with hypertension stage 3 on his medical examination at Pasar Rebo Hospital, Jakarta. Abdominal CT scan examination revealed bilateral renal artery stenosis. Percutaneous transluminal angiography (PTA) of left renal artery was performed at National Cardiovascular Centre Harapan Kita. Stent was placed succesfully and the blood pressure was normalized.
Validation of simplified predictive score for postoperative mortality after pancreaticoduodenectomy
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.667

Abstract

Background: Pancreaticoduodenectomy has long been associated with high rates of morbidity and mortality. The key to a better postoperative outcome is a good patient selection. The aim of this study was to develop a simplified preoperative predictive score for postoperative mortality after pancreaticoduodenectomy. Methods: Patients who underwent elective pancreaticoduodenectomy from 1995 to 2012 were identified from the Division of Digestive Surgery database. Bivariate analysis and multivariate logistic regression analysis identified prediction of morbidity and mortality. ROC curve estimation is use to determined the cut-off value of the predictive score. Results: Of 138 patients who underwent pancreaticoduodenectomy, 27 patients (19.6%) died. The predictor of mortality are serum total bilirubin ≥ 10 mg/dL, serum creatinin ≥ 1.3 mg/dL, hematocrit ≤ 30%, serum albumin ≤ 3.0 g/dL and ASA status ≥ 3, with assign score 1, 1, 2, 1, 1, respectively. The cut-off value was 4 with 96% sensitivity and 91% specificity. The area under the receiver operator characteristic curve was 0.974 (SE 0.011; p < 0.001), which demonstrated a reasonable predictive value for the score. Conclusion: A total score of 4 or more is associated with increased postoperative mortality in patients underwent pancreaticoduodenectomy.
Prevalence and determinants of obesity in students with intellectual disability in Jakarta
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.688

Abstract

Background: The group of people with health problems and has not received a proper attention is those with intellectual disability (ID) with obesity. The study aimed to get the prevalence of obesity in ID students in Jakarta, and to assess its relationship with age, sex, and parental education. Methods: This is a cross sectional study. The subjects are students of special schools for the disabled type C/C1 in DKI Jakarta area aged 10-30 year old. The definition of obesity for subjects aged 10-20 year old utilized the ≥ 95th percentile of BMI according to the appropriate sex and age group. Meanwhile, the definition of obesity for those aged 21-30 year old is the BMI according to WHO for Asia Pacific, which is ≥ 25.0. The analysis to test the determinant factors was performed using chi-square test. Results: The prevalence of obesity for ID students of special schools type C/C1 in DKI Jakarta area is 282 people or 16% of the total of 1,760 subjects, and there are statistically significant difference between the prevalence of obesity among the age groups (p < 0.001), sex (p = 0.039) and parental education (p < 0.006 for father’s education and p < 0.001 for mother’s education level). Conclusion: The prevalence of obesity among ID students in special schools for the disabled type C/C1 in Jakarta is 16%, with the age, sex, and parental education level as determinant factors associated with obesity.
Effect of laser photocoagulation and bevacizumab intravitreal in proliferative diabetic retinopathy: review on biomarkers of oxidative stress
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.756

Abstract

Background: This study was aimed to compare the effect of laser photocoagulation (LF), intravitreal bevacizumab (IVB) and combined treatments on biomarkers of oxidative stress such as aldehhyde dehidrogenase (ALDH), malondialdehyde (MDA) level, superoxide dismutase (SOD) activities, and vitreal vascular endothelial growth factor (VEGF) on proliferative diabetic retinopathy (DR) patients. Methods: In this single blind randomized clinical trial, 72 eyes from 69 cases of proliferative DR in Cipto Mangunkusumo Hospital between February 2011 - June 2013 were randomized into 4 groups : 1) control (n = 18); 2) LF pre-vitrectomy (n = 18); 3) IVB pre-vitrectomy (n = 18); and 4) combined IVB and LF pre-vitrectomy (n = 18). One-way ANOVA was used to compare oxidative stress parameters in the four groups. Results: There were no statistically significant differences in the average plasma ALDH activity (0.034 ± 0.02; 0.027 ± 0.02; 0.025 ± 0.02; 0.031 ± 0.11 IU/mg protein; p = 0.66), vitreal MDA level (1.661 ± 1.21; 1.557 ± 1.32; 1.717 ± 1.54; 1.501 ± 1.09 nmol/mL; p = 0.96) and SOD activity) (0.403 ± 0.50; 0.210 ± 0.18; 0.399 ± 0.49; 0.273 ± 0.32 U/mL; p = 0.38) among these four groups, respectively. However, the VEGF vitreal level (pg/mL) showed a statistically significant difference (0.356 ± 0.60; 0.393 ± 0.45; 0.150 ± 0.24; 0.069 ± 0.13; p = 0.05). The VEGF level in combination group was five times lower than the control group (p = 0.05). Conclusion: Combined treatments of DR by IVB and LF were correlated with lower vitreal MDA and plasma VEGF level, but did not have any effect on plasma ALDH and vitreal SOD in proliferative DR. Combined treatments with IVB and LF are recommended for the management of proliferative DR patients.
Effect of lyophilized amniotic membrane, hyaluronic acid, and their combination in preventing adhesion after tendon repair in New Zealand white rabbits
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.932

Abstract

Background: Several promising methods to reduce the peritendinous adhesion after repair include amniotic membrane and hyaluronic acid application on the repaired tendon site. This study aimed to compare the effect of lyophilized amniotic membrane, application of hyaluronic acid, and their combination in preventing peritendinous adhesion after tendon repair in New Zealand white rabbits.Methods: 64 flexor digitorum fibularis tendon from 16 rabbits were cut and then repaired by modified Kessler technique. Samples were allocated into four test groups; group I as control had simple tendon repair, group II had amniotic membrane wrapping at repair site, group III had hyaluronic acid application at repair site, and group IV had combination of amniotic membrane wrapping and hyaluronic acid application. On 6th week, 8 tendon from each group underwent macroscopic and histologic evaluation of peritendon adhesion by Tang scoring system. The rest of samples were evaluated for tendon gliding at tenth week by measuring active and passive range of motion of metatarsophalangeal joint.Results: At 6th week, macroscopic and histologic evaluation showed that groups II, III, and IV had significantly lower peritendinous adhesion compared to control group (p < 0.05). However, there was no significant difference found among groups II, III, and IV (p > 0.05). Similar results were found in tendon gliding evaluation, groups II, III, and IV had significantly better range of motion compared to control group (p < 0.05), but there was no significant difference found between these groups (p > 0.05).Conclusion: The application of lyophilized amniotic membrane, hyaluronic acid, or their combination significantly reduce the formation of peritendinous adhesion in repaired flexor digitorum fibularis tendon in rabbit model.
Autoclaved bone graft usage revisited
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.990

Abstract

[no abstract available]
Effect of autoclave devitalization on autograft incorporation and bone morphogenetic protein of tibia in Sprague-Dawley rats
Medical Journal of Indonesia Vol. 23 No. 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i2.992

Abstract

Background: Heating process with autoclave is one of limb salvage modalities that are widely used. but the results are not satisfying, due to mechanical bone fragility. However, considering this treatment modality is widely accepted in terms of financial, religion and sociocultural aspects, we conducted a on study rats treated with resection and reconstruction with autoclave heating method to assess bone healing by sequential radiology, histopathologic osteoblasts count, and bone morphogenetic protein (BMP). Methods: Thirty six Sprague-Dawley rats were divided into two groups with one group being the autoclave group and others served as control group. In both groups, the tibial diaphysis was extracted en bloc for 7 mm. All groups were kept for 8 weeks and treated under the same condition except the autoclave group, where the extracted bones were put into autoclave at 134°C for 15 minutes and refixed again with k-wire. We performed radiological examination at 5th and 8th week using Lane and Sandhu radiological score. After extraction, the tibial bones were inspected for histological pattern using Salked modified score, osteoblast quantity counting and BMP-2 values. Results: There were statistically significant diffences between control and autoclave group on radiological score at 5 th (5.12 ± 1.6 g vs 3.21 ± 2.42, p = 0.023) and 8 th week (6.06 ± 1.71 vs 4.29 ± 2.53, p = 0.040), histological score between groups (6.06 ± 1.14 vs 4.14 ± 1.99, p = 0.005), osteoblast count (p < 0.001), and BMP-2 expression, respectively. Conclusion: Autoclave recycling autograft lowered the speed of graft incorporation and BMP-2 expression. Therefore, autoclave recycling autograft as a method of limb salvage surgery must be reevaluated and not considered to be applied for treatment in bone malignancy.

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