cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Tsania Faza
Contact Email
-
Phone
08111400115
Journal Mail Official
mji@ui.ac.id
Editorial Address
Education Tower 6th floor, IMERI building, Faculty of Medicine Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia
Location
Kota depok,
Jawa barat
INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
Arjuna Subject : -
Articles 14 Documents
 1   2 
Search results for , issue "Vol. 26 No. 1 (2017): March" : 14 Documents clear
Reducing severe spasticity in cerebral palsy following meningoencephalitis by botulinum toxin
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1297

Abstract

A 3-year-old boy diagnosed with diplegic cerebral palsy had received Botulinum toxin injection to reduce severe spasticity. There was an improvement of muscles tone and motor function including better ability of limb flexion of the knees and hip, adduction of the hip, flexion of the toes, and plantar flexion of the foot. No side effect was observed after the procedure.
Chlorhexidine-alcohol versus povidone-iodine as preoperative skin preparation to prevent surgical site infection: a meta-analysis
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1388

Abstract

Background: Surgical site infection remains substantial problems to surgeons and patients as it increases the morbidity, mortality, length of stay, hospital cost, rate of re-admission, and rate of re-surgery. This study aims to compare the use of chlorhexidine-alcohol versus povidone-iodine for preoperative skin preparation to prevent surgical site infection.Methods: The literature search was conducted through the PubMed database on November 2015. Included studies were RCTs with the year of publication up to 2015 which compared the use of chlorhexidine-alcohol versus povidone-iodine in its effectiveness reducing surgical site infection in adult patients. The quality of the study was assessed using Jadad Score. A meta-analysis was conducted in the included study to obtain a pooled estimate of the effect size. The evidence of heterogeneity and publication bias was also assessed.Results: Six RCTs with a total of 2,080 patients were included in the meta-analysis. It showed that the use of chlorhexidine-alcohol was associated significantly with fewer SSIs (pooled risk ratio=0.60 (95% CI=0.45-0.79)) and fewer positive skin culture results (pooled risk ratio, RR=0.38 (95% CI=0.28-0.51)) compared with povidone iodine.Conclusion: Preoperative skin antisepsis with chlorhexidine is more effective than povidone-iodine in preventing surgical site infection.
Effectiveness of combined laser-puncture and conventional wound care to accelerate diabetic foot ulcer healing
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1401

Abstract

Background: Impaired wound healing is a common complication of diabetes. It has complex pathophysiologic mechanisms and often necessitates amputation. Our study aimed to evaluate the effectiveness of combined laser-puncture and conventional wound care in the treatment of diabetic foot ulcers. Methods: This was a double-blind controlled randomized clinical trial on 36 patients, conducted at the Metabolic Endocrine Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, between May and August 2015. Stimulation by laser-puncture (the treatment group) or sham stimulation (the control group) were performed on top of the standard wound care. Laser-puncture or sham were done on several acupuncture points i.e. LI4 Hegu, ST36 Zusanli, SP6 Sanyinjiao and KI3 Taixi bilaterally, combined with irradiation on the ulcers itself twice a week for four weeks. The mean reduction in ulcer sizes (week 2–1, week 3–1, week 4–1) were measured every week and compared between the two groups and analyzed by Mann-Whitney test. Results: The initial median ulcer size were 4.75 (0.10–9.94) cm2 and 2.33 (0.90–9.88) cm2 in laser-puncture and sham groups, respectively (p=0.027). The median reduction of ulcer size at week 2–1 was -1.079 (-3.25 to -0.09) vs -0.36 (-0.81 to -1.47) cm2, (p=0.000); at week 3–1 was -1.70 (-3.15 to -0.01) vs -0.36 (-0.80 to -0.28) cm2, (p=0.000); and at week 4–1 was -1.22 (-2.72 to 0.00) vs -0.38 (-0.74 to -0.57) cm2, (p=0.012). Conclusion: Combined laser-puncture and conventional wound care treatment are effective in accelerating the healing of diabetic foot ulcer.
The accuracy of Aziza’s scoring system in limited slice non-enhanced thoracic CT for the diagnosis of adult pulmonary tuberculosis
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1432

Abstract

Background: Tuberculosis (TB) is still a major cause of morbidity and mortality in Indonesia. Thus, a fast and accurate method in diagnosing pulmonary TB (PTB) is needed, especially in adult smear-negative-TB cases. The purpose of this study was to determine the accuracy of a novel scoring system (Aziza’s score) using clinical data and characteristic abnormalities that are found in the limited slice non-enhanced thoracic CT. Methods: This was a prospective cross-sectional study. A limited slice non-enhanced thoracic CT was performed to establish a diagnosis of PTB in patients with suspected PTB and to assess the diagnostic value of the scoring system. A reference standard used in this study was the clinical expertise of two pulmonologists. The scoring system was analyzed using bivariate and multivariate Cox regression analysis. Results: 84 of 130 suspected PTB patients were diagnosed as PTB. They were diagnosed based on pulmonary characteristic abnormalities that were found in the limited slice non-enhanced thoracic CT. The scoring system was analyzed using bivariate and multivariate Cox regression analysis. The total scores which were equal to or more than 29 could diagnose PTB with the accuracy of 96.1% (95% CIs=91.3–98.3), sensitivity of 96.5% (95% CIs=90.1–98.8), and specificity of 95.6% (95% CIs=90.1–98.8), This novel scoring method was name as an Aziza’s scoring system. Conclusion: Aziza’s scoring system performed in the limited slice non-enhanced thoracic CT has a higher accuracy compared to the reference standard for the diagnosis of adult PTB.
Clinical characteristics of acute respiratory distress syndrome survived patients at a tertiary hospital in Jakarta
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1470

Abstract

Background: While a good deal of research on characteristic the different characteristics between surviving and dying patient with ARDS has been conducted globally, such research is scarce in developing countries. This study aimed to obtain clinical profile of ARDS survivors during hospitalization. Methods: This was a prospective, observational study conducted at a tertiary hospital in Jakarta from October 2015 to April 2016. Primary data was collected from ARDS patients based on Berlin Definition admitted to emergency room, ICU, HCU, ICCU, and all other wards. The patients were followed until they discharged. We only included survivors on the analysis. Descriptive analysis was done using SPSS 21.0. Results: A total of 43 patients were survived during study period. The majority were below 65 years of age (69.8%) and were male (53.5%). ARDS was mainly mild in severity (62.8%) and early onset (55.8%). Sepsis was the most common causes of ARDS (97.7%). Most of the patients had comorbidities (74.4%). Majority of the patients had APACHE II score <20 (77.3%) with mean 15.6±4.8. The mean of albumin was 2.9±0.6 and the median of procalcitonin was 3 (0.1-252.3). Conclusion: The clinical profile of ARDS survivors in our study were mostly similar with other studies conducted in developed and other developing countries.
Clinical and ultrasound joint outcomes in severe hemophilia A children receiving episodic treatment in Indonesian National Hemophilia Treatment Center
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1494

Abstract

Background: Recurrent joint bleeds leading to arthropathy is the main problem in severe hemophilia children. This study aimed to investigate joint status in severe hemophilia A children receiving episodic treatment in Cipto Mangunkusumo Hospital, Jakarta. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo Hospital as Indonesian National Hemophilia Treatment Center on children (4–18 years) with severe hemophilia A, who previously received episodic treatment, with no history of inhibitor factor VIII. Hemophilia Joint Health Score was evaluated according to HJHS version 2.1 2011. Joint ultrasonography was done for six index joints (bilateral elbows, knees and ankles) using Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) methods. Data of age of first joint bleed, number of target joints and inhibitor factor VIII were obtained from the Pediatric Hemophilia Registry and medical records. Results: There were 59 subjects aged 4 to 18 years. Twentynine out of 59 (49.2%) subjects experienced first joint bleed before of 2 years of age. The most common of joint bleeds was a right ankle. Mean total HJHS was 8.71±8.73. Subjects aged 4–10 years showed lower HJHS (4.6±3.7) as compared to subjects aged >10–18 years (12.3±10.3), p<0.001; 95% CI=4.9–13. Mean HEAD-US scores in subjects aged 4–10 years (18.7±5.6) was lower than in subjects aged >10–18 years (28±7.9), p<0.001, 95% CI= -12.9–-5.6. Conclusion: HJHS and HEAD-US scores of severe hemophilia A children receiving episodic treatment aged 4–10 years are lower compared to subjects aged >10–18 years, indicating more severe joint destruction in older children and progressivity of joint damage over time. It is important to start prophylactic treatment to prevent progressivity of joint damage.
The suppression of manganese superoxide dismutase decreased the survival of human glioblastoma multiforme T98G cells
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1511

Abstract

Background: Glioblastoma multiforme (GBM) is a primary malignant brain tumor which has poor prognosis. High incidence of oxidative stress-based therapy resistance could be related to the high antioxidant status of GBM cells. Our previous study has reported that manganese superoxide dismutase (MnSOD) antioxidant expression was significantly higher in high grade glioma than in low grade. The aim of this study was to analyze the impact of MnSOD suppression toward GBM cell survival.Methods: This study is an experimental study using human glioblastoma multiforme T98G cell line. Suppression of MnSOD expression was performed using in vitro transfection MnSOD-siRNA. The MnSOD expression was analyzed by measuring the mRNA using real time RT-PCR, protein using ELISA technique, and specific activity of enzyme using inhibition of xantine oxidase. Concentration of reactive oxygen species (ROS) intracellular was determined by measuring superoxide radical and hydrogen peroxide. Cell survival was analyzed by measuring viability, proliferation, and cell apoptosis.Results: In vitro transfection of MnSOD-siRNA suppressed the mRNA, protein, and specific activity of MnSOD. This treatment significantly increased the concentration of superoxide radical; however, it did not influence the concentration of hydrogen peroxide. Moreover, viability MnSOD-suppressing cell significantly decreased, accompanied by increase of cell apoptosis without affecting cell proliferation.Conclusion: The suppression of MnSOD expression leads to decrease glioblastoma multiforme cell survival, which was associated to the increase of cell apoptotic.
High frequency of NAT2 slow acetylator alleles in the Malay population of Indonesia: an awareness to the anti-tuberculosis drug induced liver injury and cancer
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1563

Abstract

Background: Arylamine N-acetyltransferase 2 (NAT2) polymorphism was previously reported to have association with the risk of drug toxicities and the development of various diseases. Previous research on the Indonesian population, especially Javanese and Sundanese, showed that there were 33% NAT2 slow acetylator phenotype. The aim of this study was to map the NAT2 variation in the Malay ethnic to gain a deeper insight into NAT2 haplotypic composition in this ethnic.Methods: 50 healthy samples from the Indonesian Malay ethnic were obtained. They were interviewed about their ethnic backgrounds for the last three generations. DNA was extracted from peripheral blood and NAT2 genotyping was done using the PCR direct Sequencing. Data were compiled according to the genotype and allele frequencies estimated from the observed numbers of each specific allele. Haplotype reconstruction was performed using PHASE v2.1.1 software.Results: We found 7 haplotypes consisting of 6 SNPs and 14 NAT2 genotype variations in Indonesian Malay population. The most frequent allele was NAT2*6A (38%) which was classified as a slow acetylator allele. According to bimodal distribution, the predicted phenotype of the Malay population was composed of 62% rapid acetylator and 38% slow acetylator. According to trimodal distribution, the predicted phenotypes for rapid, intermediate and slow acetylators were 10%, 52% and 38% respectively.Conclusion: Our result indicates the presence of the allelic distribution and revealed the most frequent acetylator status and phenotype for the Indonesian Malay population. The result of this study will be helpful for future epidemiological or clinical studies and for understanding the genetic basis of acetylation polymorphism in Indonesia.
Association between obesity and behavioral/emotional disorders in primary school-aged children: a cross-sectional study
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1564

Abstract

Background: Obesity in children can increase the risks of various chronic diseases. Mental disorders associated with obesity in children include: depression, anxiety, low self-esteem, hyperkinetic disorders, and increased aggressiveness. This relationship is estimated due to vulnerable genetic expressions in obese individuals. This study aimed to find the association between obesity and behavioral/emotional disorder in primary school-aged children. Methods: This cross-sectional study was conducted on 384 children at Menteng 1 Elementary School, Jakarta from July to September 2015. The study was conducted to find the association between the children’s nutritional status and behavioral/emotional disorders screened by the 17-item Pediatric Symptom Checklist (PSC-17). Chi square analysis was applied in this study. Results: The prevalence of obese children at Menteng 1 Elementary School, Jakarta reached 23.2%, which is higher than Jakarta’s prevalence (14%). 8.7% of the subjects were obese and 13.6% of them were having behavioral/emotional disorders. 20.0% of the obese subjects had behavioral/emotional disorders. The prevalence was higher for internalizing subscale, which was consistent with other studies. Association between obesity and behavioral/emotional disorders was significant for externalizing sub-scale (p=0.036). Externalizing problems caused by obesity might be affected by the social stigma of their peer group. However, obesity in children did not have a statistically significant relationship in internalization sub-scale, attention, and PSC-17 total score (p>0.05). No significant associations towards those sub-scales were thought to be influenced by other factors, playing a role in causing mental disorders in children. Conclusion: In general, obesity was not associated with behavioral and emotional disorders in children, but obesity was related to externalizing behavioral/emotional disorders.
Association between public knowledge regarding antibiotics and self-medication with antibiotics in Teling Atas Community Health Center, East Indonesia
Medical Journal of Indonesia Vol. 26 No. 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v26i1.1589

Abstract

Background: Self-medication with antibiotics increases the risk of resistance, which leads to higher morbidity and mortality. The community plays an important role in preventing and controlling the spread of antibiotic resistance. This study aims to determine factors associated with antibiotics self-medication practices in the community, which are the key to developing effective intervention programs. Methods: This cross-sectional study was conducted between September and October 2015 at Teling Atas Community Health Center in Wanea, a sub-district of East Indonesia region. Data was collected by a questionnaire-guided interview. There were 35 questions which cover respondent demographics, antibiotic use, and respondents’ knowledge about antibiotics. Logistic regression was used to analyze the association between self-medication with antibiotics and respondents’ level of knowledge as well as other factors. Results: Among 400 respondents, there were 240 (60%) who had used antibiotics within 6 months prior to the interview and 180 (45.0%) who had self-medicated. Wounds or skin diseases (32.2%) were main reasons for self-medication. The majority of respondents self-medicated on their own initiatives (70.6%) and purchased antibiotics in pharmacies (52.2%). The mean score for respondent knowledge about antibiotic was categorized as “moderate” (score 7.14±2.49). Respondents with lower knowledge scores had higher probabilities to self-medicate with antibiotics than those with higher scores (OR= 16.86; 95% CI= 4.25–66.83). Conclusion: Self-medication practices with antibiotics in this study are associated with age, family income, and knowledge. Since poorer knowledge about antibiotics is associated with a higher probability of self-medication with antibiotics, education programs to improve public awareness are needed.

Page 1 of 2 | Total Record : 14

 1   2 

Filter by Year

2017 2017


Reset
Filter By Issues
All Issue Online First Vol. 34 No. 4 (2025): December Vol. 34 No. 3 (2025): September Vol. 34 No. 2 (2025): June Vol. 34 No. 1 (2025): March Vol. 33 No. 4 (2024): December Vol. 33 No. 3 (2024): September Vol. 33 No. 2 (2024): June Vol. 33 No. 1 (2024): March Vol. 32 No. 4 (2023): December Vol. 32 No. 3 (2023): September Vol. 32 No. 2 (2023): June Vol. 32 No. 1 (2023): March Vol. 31 No. 4 (2022): December Vol. 31 No. 3 (2022): September Vol. 31 No. 2 (2022): June Vol. 31 No. 1 (2022): March Vol. 30 No. 4 (2021): December Vol. 30 No. 3 (2021): September Vol. 30 No. 2 (2021): June Vol. 30 No. 1 (2021): March Vol. 29 No. 4 (2020): December Vol. 29 No. 3 (2020): September Vol. 29 No. 2 (2020): June Vol. 29 No. 1 (2020): March Vol. 28 No. 4 (2019): December Vol. 28 No. 3 (2019): September Vol. 28 No. 2 (2019): June Vol. 28 No. 1 (2019): March Vol. 27 No. 4 (2018): December Vol. 27 No. 3 (2018): September Vol. 27 No. 2 (2018): June Vol. 27 No. 1 (2018): March Vol. 26 No. 4 (2017): December Vol. 26 No. 3 (2017): September Vol. 26 No. 2 (2017): June Vol. 26 No. 1 (2017): March Vol. 25 No. 4 (2016): December Vol. 25 No. 3 (2016): September Vol. 25 No. 2 (2016): June Vol. 25 No. 1 (2016): March Vol. 24 No. 4 (2015): December Vol. 24 No. 3 (2015): September Vol. 24 No. 2 (2015): June Vol. 24 No. 1 (2015): March Vol. 23 No. 4 (2014): November Vol. 23 No. 3 (2014): August Vol. 23 No. 2 (2014): May Vol. 23 No. 1 (2014): February Vol. 22 No. 4 (2013): November Vol. 22 No. 3 (2013): August Vol. 22 No. 2 (2013): May Vol. 22 No. 1 (2013): February Vol. 21 No. 4 (2012): November Vol. 21 No. 3 (2012): August Vol. 21 No. 2 (2012): May Vol. 21 No. 1 (2012): February Vol. 20 No. 4 (2011): November Vol. 20 No. 3 (2011): August Vol. 20 No. 2 (2011): May Vol. 20 No. 1 (2011): February Vol. 19 No. 4 (2010): November Vol. 19 No. 3 (2010): August Vol. 19 No. 2 (2010): May Vol. 19 No. 1 (2010): February Vol. 18 No. 4 (2009): October-December Vol. 18 No. 3 (2009): July-September Vol. 18 No. 2 (2009): April-June Vol. 18 No. 1 (2009): January-March Vol. 17 No. 4 (2008): October-December Vol. 17 No. 3 (2008): July-September Vol. 17 No. 2 (2008): April-June Vol. 17 No. 1 (2008): January-March Vol. 16 No. 4 (2007): October-December Vol. 16 No. 3 (2007): July-September Vol. 16 No. 2 (2007): April-June Vol. 16 No. 1 (2007): January-March Vol. 15 No. 4 (2006): October-December Vol. 15 No. 3 (2006): July-September Vol. 15 No. 2 (2006): April-June Vol. 15 No. 1 (2006): January-March Vol. 14 No. 4 (2005): October-December Vol. 14 No. 3 (2005): July-September Vol. 14 No. 2 (2005): April-June Vol. 14 No. 1 (2005): January-March Vol. 13 No. 4 (2004): October-December Vol. 13 No. 3 (2004): July-September Vol. 13 No. 2 (2004): April-June Vol. 13 No. 1 (2004): January-March Vol. 12 No. 4 (2003): October-December Vol. 12 No. 3 (2003): July-September Vol. 12 No. 2 (2003): April-June Vol. 12 No. 1 (2003): January-March Vol. 11 No. 4 (2002): October-December Vol. 11 No. 3 (2002): July-September Vol. 11 No. 2 (2002): April-June Vol. 11 No. 1 (2002): January-March Vol. 10 No. 4 (2001): October-December Vol. 10 No. 3 (2001): July-September Vol. 10 No. 2 (2001): April-June Vol. 10 No. 1 (2001): January-March Vol. 9 No. 4 (2000): October-December Vol. 9 No. 3 (2000): July-September Vol. 9 No. 2 (2000): April-June (Special Issue: Skin Cancer) Vol. 9 No. 1 (2000): January-March Vol. 8 No. 4 (1999): October-December Vol. 8 No. 3 (1999): July-September Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer) Vol. 8 No. 1 (1999): January-March (Special Issue: Implant Contraceptive) Vol. 7 No. 4 (1998): October-December Vol. 7 No. 3 (1998): July-September Vol. 7 No. 2 (1998): April-June Vol. 7 (1998): Supplement 1 Vol. 7 No. 1 (1998): January-March Vol. 6 No. 4 (1997): October-December Vol. 6 No. 3 (1997): July-September Vol. 6 No. 2 (1997): April-June Vol. 6 No. 1 (1997): January-March Vol. 5 No. 4 (1996): October-December Vol. 5 No. 3 (1996): July-September Vol. 5 No. 2 (1996): April-June Vol. 5 No. 1 (1996): January-March Vol. 4 No. 4 (1995): October-December Vol. 4 No. 3 (1995): July-September Vol. 4 No. 2 (1995): April-June Vol. 4 No. 1 (1995): January-March Vol. 3 No. 4 (1994): October-December Vol. 3 No. 3 (1994): July-September Vol. 3 No. 2 (1994): April-June Vol. 3 No. 1 (1994): January-March Vol. 2 No. 1 (1993): January-March Vol. 1 No. 3/4 (1992): July-December Vol. 1 No. 2 (1992): April-June Vol. 1 No. 1 (1992): January-March More Issue