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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 14 Documents
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Search results for , issue "Vol. 30 No. 2 (2021): June" : 14 Documents clear
Reliability and validity of the Indonesian version of the World Health Organization quality of life-old (WHOQOL-OLD): a Rasch modeling
Medical Journal of Indonesia Vol. 30 No. 2 (2021): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.215065

Abstract

BACKGROUND The World Health Organization (WHO) has developed the WHOQOL-OLD instrument, specifically measuring the quality of life (QoL) of the elderly, but the Indonesian version of the WHOQOL-OLD has not been available. METHODS This study was conducted in 2 steps. First, the instrument was translated and pre-tested to 8 elderly respondents from 2 villages in Lembang, West Java, Indonesia. Second, Rasch modeling was used as implemented by the Winstep version 3.73 software to analyze the reliability, validity, value of separation, Wright map analysis, item-fit order, and differential item functioning in elderly respondents (aged ≥60 years old and did not have dementia) from 6 community health centers in Bangka Regency, Bangka Belitung, Indonesia from July to December 2018. RESULTS Overall, the Indonesian version of the WHOQOL-OLD demonstrated good reliability and validity tests in 175 respondents. The overall value of the person reliability was 0.73 with the Cronbach’s alpha of 0.75, and the value of the item reliability was 0.97. A misconception and bias occurred in the death and dying facet, especially in the demographic categories of age, gender, and marital status. CONCLUSIONS The Indonesian version of the WHOQOL-OLD module has good psychometric properties to measure the QoL of the Indonesian older population. However, further studies involving various ethnicities, religious groups, and districts in Indonesia should be carried out before the module can be used throughout the country.
Analysis of SARS-CoV-2 nucleocapsid protein sequence variations in ASEAN countries
Medical Journal of Indonesia Vol. 30 No. 2 (2021): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.215304

Abstract

BACKGROUND Nucleocapsid (N) protein is one of four structural proteins of SARS-CoV-2 which is known to be more conserved than spike protein and is highly immunogenic. This study aimed to analyze the variation of the SARS-CoV-2 N protein sequences in ASEAN countries, including Indonesia. METHODS Complete sequences of SARS-CoV-2 N protein from each ASEAN country were obtained from Global Initiative on Sharing All Influenza Data (GISAID), while the reference sequence was obtained from GenBank. All sequences collected from December 2019 to March 2021 were grouped to the clade according to GISAID, and two representative isolates were chosen from each clade for the analysis. The sequences were aligned by MUSCLE, and phylogenetic trees were built using MEGA-X software based on the nucleotide and translated AA sequences. RESULTS 98 isolates of complete N protein genes from ASEAN countries were analyzed. The nucleotides of all isolates were 97.5% conserved. Of 31 nucleotide changes, 22 led to amino acid (AA) substitutions; thus, the AA sequences were 94.5% conserved. The phylogenetic tree of nucleotide and AA sequences shows similar branches. Nucleotide variations in clade O (C28311T); clade GR (28881–28883 GGG>AAC); and clade GRY (28881–28883 GGG>AAC and C28977T) lead to specific branches corresponding to the clade within both trees. CONCLUSIONS The N protein sequences of SARS-CoV-2 across ASEAN countries are highly conserved. Most isolates were closely related to the reference sequence originating from China, except the isolates representing clade O, GR, and GRY which formed specific branches in the phylogenetic tree.
The importance of registry for systematic review and clinical trial
Medical Journal of Indonesia Vol. 30 No. 2 (2021): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.ed.215620

Abstract

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Medical Journal of Indonesia Vol. 30 No. 2 (2021): June
Publisher : Faculty of Medicine Universitas Indonesia

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