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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
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Search results for , issue " Vol 2, No 2 (2013)" : 1 Documents clear
Effect of D-Alpha Tocopherol Therapy towards Malondialdehyde Level and Histology of Kidney in Rattus norvegicus with MLD-STZ Induction Agnestiansyah, Marissa; Mahdi, Chanif
The Journal of Pure and Applied Chemistry Research Vol 2, No 2 (2013)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.207 KB)

Abstract

ABSTRACT Diabetic Nephropathy is a kidney disease which occurs due to complication of diabetes mellitus  as a consequence of the damage of the kidney endothelial cells. Hyperglicemia condition in patients with diabetes mellitus that induces an oxidative stress, were related to endothelial cell damage. Oxidative stress as a result of hyperglycemia will activate a number of signal transduction pathways resulting in increase of  free radicals. D-alpha tocopherol as one of antioxidant substance, that can act as an inhibitor of free radical chain reactions, play an important role in the reduction of the oxidative stress effect. Effect of D-alpha-tocopherol in reducing oxidative stress is identified by the levels of malondialdehyde (MDA) in kidney and histology of kidney. This study used five groups mice; they were a control group, a diabetic group which was induced with MLD-STZ, and a therapeutic groups with a varieties doses of D-alpha tocopherol (100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW). The results showed that the D-alpha tocopherol was able to reduce the levels of malondialdehyde (MDA) and repair the histology of kidney of mice induced by MLD-STZ.   Keywords: Diabetic Nephropathy, Diabetes mellitus, MLD-STZ, Malondialdehyde, D-Alpha tocopherol  

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