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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol. 14 No. 1 (2025): Edition January-April 2025" : 7 Documents clear
The Effect of Temperature and Solvent Concentration on Chemical and Physical Properties of Carrageenan from Gracilaria gracilis Erawati, Emi; Fatoni, Rois; Hamid, Hamid; Noviasari, Tri
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.695

Abstract

Carrageenan is a polysaccharide extracted from seaweed sap using either air or an alkaline solution, such as Gracilaria gracilis. It functions as a thickening, emulsifying, suspending, and stabilizing agent. This paper reports the effect of KOH concentrations and temperatures on the extraction, in addition to determining the physical and chemical properties of the seaweed. A dried G. gracilis was soaked in distilled water for 24 hours and heated at 85°C for two hours. It was found the fat content was 3.56%, protein content 17.68%, moisture content 1.984%, and ash content of 26.547%. The highest values for water holding capacity (WHC) were 4.07 g/g, oil holding capacity (OHC) 3.539 g/g, swelling capacity (SC) at 1.894 mL/g, solubility index (SI) at 10.843 g/100g, emulsifying activity (EA) at 73.483%, and pH at 7.520.
Antibacterial Potential of SrBi2Ta2O9 Synthesized via Molten Salt Method Izzah, Nuril Lailatul; Savira, Amalia; Ma’unatin, Anik; Safitri, Widya Nur; Hardian, Arie; Prasetyo, Anton
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.014.01.3352

Abstract

One of the interesting properties of Aurivillius compounds is photocatalysts; therefore, they have the potential to be used as antibacterials. However, the study of the antibacterial properties of Aurivillius compounds is still very limited, therefore it’s important to conduct research on it’s properties. Our research aims to study the photocatalytic activity of SrBi2Ta2O9 compounds synthesized by molten salt method (using NaCl/KCl salt) as antibacterial. The diffractogram of the sample shows that the SrBi2Ta2O9 was successfully synthesized, but an impurity phase was formed as Bi2O3, Ta2O5, and SrBi2.83Ta5O15. The SEM images show that the morphological shape obtained is plate-like, which still has agglomeration with particle size distribution at range 20-80 μm. Plot tauc shows that the band gap energy of SrBi2Ta2O9 compounds is 2.8 and 3.06 eV, respectively. The antibacterial activity test results showed that the SrBi2Ta2O9 compound can inhibit staphylococcus bacterial growth under and without light radiation. It indicates that there are two possible mechanisms related to the inhibition of bacterial growth i.e: (a) photocatalysis, and (b) toxicity properties.
Antioxidant Potential of Secondary Metabolite from Kelakai (Stenochlaena palustris) as a Natural Growth Promoter Through Inhibition of Inducible Nitrite Oxide Synthase (iNOS) Irmawan, Muhammad; Kumalasari, Meiyanti Ratna; Sandriya, Ardi; Fariz Noorrahman, Nabil; Ysrafil, Ysrafil; Tesalonika, Lidya
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.6534

Abstract

Kelakai (Stenochlaena palustris), a plant native to Central Kalimantan, is recognized for its potent antioxidant properties. This study aimed to investigate the preparation, extraction, phytochemical composition, antioxidant potential, and molecular interactions of secondary metabolites derived from Kelakai, emphasizing its health-promoting benefits and possible use as a natural growth enhancer. The findings revealed that the Kelakai extract contained various secondary metabolites, including alkaloids (8.868%), flavonoids (5.3%), saponins (10.76%), phenolics (1.246%), tannins (0.067%), and triterpenes (30.7%). The extract demonstrated a powerful antioxidant effect, with an IC50 value of 44.81 μg/mL. Molecular docking analysis identified chlorogenic acid and eucalyptol as essential compounds contributing to the extract's antioxidant activity. These compounds effectively inhibit the iNOS protein, with binding free energy (ΔGbinding) values of -10.3044 kcal/mol and -6.0872 kcal/mol, respectively. These findings suggest that kelakai extract possesses significant antioxidant potential and may offer valuable applications as a natural growth promoter for broiler chickens.
Exploration of Total Flavonoid Content, Toxicity, and Antibacterial Activity of Acorus calamus L. Rhizome Isolates Amalia, Suci; Jannah, Faridatul; Afriani, Ida Irma; Dewi, Diana Candra; Fasya, A. Ghanaim
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7914

Abstract

Acorus calamus L. is a medicinal plant with rhizomes commonly used in traditional medicine. This study aimed to determine the total flavonoid content, toxicity, and antibacterial activity of isolates from the rhizome of Acorus calamus L. The rhizome extract was sonicated using 70% ethanol, yielding 18.73% (w/w), and partitioned using ethyl acetate, yielding 10.80% (w/w). Subsequently, the ethyl acetate fraction was further separated using column chromatography. FTIR analysis of the ethanol extract, ethyl acetate fraction, and column isolates confirmed the presence of O–H functional groups and other vibrations, indicating the presence of flavonoid compounds. UV analysis revealed absorption at the band I (302, 302, 383 nm) and band II (253, 254, 258 nm). The total flavonoid content of the isolates, determined using AlCl3, was 32.95 mg QE/g. Liquid Chromatography-Mass Spectrometry (LC-MS) analysis of the column chromatography isolates identified the presence of isorhamnetin, quercetin, genistein, and glycitein. Furthermore, toxicity and antibacterial activity tests on the ethanol extract and ethyl acetate fraction showed LC50 values of 143.53 ppm and 41.16 ppm, respectively, and inhibition zone diameters ranging from 2.30-4.54 mm and 2.63-5.29 mm, respectively.
Analysis of Total Phenolic Content and Antibacterial Activity of Black Pomegranate Peel (Punica granatum L.) as an Antibiotic Agent Innovation Allinha Yusfin Innaya; Majida Ramadhan; Syauqi, Ahmad
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7927

Abstract

Pomegranate is one of the most potential natural resources due to its various compounds, especially in black pomegranate skin. Pomegranate peels are often considered as unusable residue. However, black pomegranate peels have high potential phenolic content and antibacterial properties than other types of pomegranates. This study aims to analyze the total phenolic content and test the antibacterial activity of black pomegranate peel as an antibiotic agent. The method used on the total phenolic content is Folin-Ciocalteau method with UV-VIS Spectrophotometer. Meanwhile, the antibacterial activity test was carried out by the diffusion method with MHA and MHB media against Gram-Positive and Gram-Negative bacteria, namely Eschericia coli and Staphylococcus aureus and positive control using apmhicilin and chloramphenicol. Bacteria were streaked on sterile solid media using sterile cotton buds. The results obtained on the total phenolic content of black pomegranate skin resulted in 90.89 μg GAE/mL sample. Meanwhile, the antibacterial properties obtained the largest diameter of the inhibition zone on Eschericia coli and Staphylococcus aureus respectively, namely 23.4 ± 0.19 and 21.7 ± 0.35 mm. The results showed that black pomegranate peel contributes significantly to environmentally friendly antibacterial properties and can be an innovation in antibiotic development. These findings, open up new opportunities in the formulation of natural antibiotic products that are effective and safe for humans.
The Effect of Surfactant on the Characteristics of Curcumin-Loaded Nanostructured Lipid Carriers: Fluorescence and Stability Study Mega Nurul Madania; Zubaidah Ningsih; Anastasia Fitria Devi; Diah Mardiana; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7933

Abstract

Curcumin, a bioactive compound derived from Curcuma longa, offers significant pharmacological benefits such as antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic application is restricted due to poor water solubility, low systemic bioavailability, and limited skin penetration. This study explores the use of Nanostructured Lipid Carriers (NLCs) as a drug delivery system to improve curcumin's stability and permeability. Two formulations were developed: NLC-KUR-T80, which encapsulates curcumin using the non-ionic surfactant Tween 80, and NLC-KUR-CTAB, which uses the cationic surfactant CTAB. Both formulations were prepared using the Phase Inversion Temperature (PIT) method and characterized for particle size, polydispersity index (PI), zeta potential, encapsulation efficiency (EE%), and fluorescence properties. Results revealed that CUR-NLC-CTAB exhibited a larger particle size (1410 ± 183 nm), higher zeta potential (78.70 ± 0.67 mV), and significantly better encapsulation efficiency (27.33 ± 3.33%) compared to CUR-NLC-T80. Fluorescence studies demonstrated that curcumin within NLC-CTAB had enhanced fluorescence intensity, indicating better stability and distribution within the lipid matrix.
Design, Synthesis, and In Silico Study of Two N-Substituted Pyrazinamide Analogs as Potential Antituberculosis Agents Zulqurnain, Muhammad; Wati, First Ambar; Nurjanah, Ana; Kavin, Layli Adha Nadira; Afifah, Rizqi Nur; Suyatno; Santoso, Mardi
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7939

Abstract

Tuberculosis (TB) is an infectious yet often overlooked disease that remains a significant global challenge. Pyrazinamide (PZA), a key drug in the first-line TB treatment regimen, is used to reduce the duration of therapy, making it a compound of great interest for further exploration. Two pyrazine-2-carboxamide analogs have been successfully synthesized and reported, followed by an in-silico evaluation of their potency as antituberculosis agents. Yamaguchi reagent was employed as a coupling agent between pyrazine-2-carboxylic acid and corresponding amine, yielding N-(cyclohexylmethyl) pyrazine-2-carboxamide (D) and N-(4-cyclooctyl) pyrazine-2-carboxamide (E) in 60% and 55%, respectively. The molecular docking analysis of compounds (D) and (E) demonstrated lower binding energies (-7.65 and -7.37 kcal/mol, respectively), in comparison with the standard TB drugs, pyrazinamide and isoniazid. Additionally, ADME and pharmacokinetics evaluations revealed that compounds (D) and (E) meet the essential criteria for oral drug candidacy. These findings suggest that the pyrazinamide analogs (D) and (E) hold significant potential as promising antimycobacterial agents for tuberculosis therapy.

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