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INDONESIA
Berkala Ilmu Kesehatan Kulit dan Kelamin
Published by Universitas Airlangga
ISSN : 19784279     EISSN : 25494082     DOI : 10.20473
Core Subject : Health, Science,
Immunology & microbiology Public Health
Arjuna Subject : -
Articles 12 Documents
 1   2 
Search results for , issue "Vol. 29 No. 2 (2017): AGUSTUS" : 12 Documents clear
Profile of Serum Interleukin-31 Levels in Atopic Dermatitis Dewi Kusumawati; Cita Rosita Prakoeswa; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.775 KB) | DOI: 10.20473/bikk.V29.2.2017.142-150

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31). This cytokine is considered to be a potential mediator inducing pruritus in AD. Several studies reported a direct correlation between serum IL-31 level and severity of AD, probably due to the ability of this cytokine to increase the inflammatory response through the initiation of the expression of proinflammatory cytokines and chemokines. Purpose: To evaluate the serum level of IL-31 in AD patients. Methods: Thirty-four AD patients who defined according to the criteria of United Kingdom (UK) Working Party were included in this descriptive observational cross-sectional study. Samples were taken from peripheral venous blood and IL-31 serum levels were measured using ELISA. Results: Mean IL-31 serum level was 99.43±72.91 pg/mL, with the lowest level of 6.84 pg/mL and the highest level of 281.25 pg/mL. Conclusion: IL-31 seems to have a role in atopic dermatitis but further investigation is required.
Association of Serum Testosterone with Various Severity of Acne Vulgaris in Adult Women Umi Miranti; Diah Mira Indramaya; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.436 KB) | DOI: 10.20473/bikk.V29.2.2017.98-105

Abstract

Background: Acne Vulgaris (AV) is a chronic and obstructive inflammatory skin disease of the pilosebaceous unit. Testosterone is main androgen hormone that have a role in the pathogenesis of AV. Pevious researches have shown controversial results regarding serum testosterone levels in AV. Purpose: To evaluate the association of serum testosterone levels with AV severity in adult women in Dermatovenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya. Methods: This is an analitic observational study, with 37 patients based on the inclusion and exclusion criteria. Results: Mean serum testosterone level in mild AV group was 39.16 + 24.18µg/dL, moderate AV group was 39.75 + 23.75 µg/dL, and severe AV group was 52.46 + 24.00 µg/dL. These results indicate that serum testosterone level in severe AV group was higher than moderate and mild AV groups. But there was no statistically significant correlation between serum testosterone levels and the severity of AV. Conclusions: Serum testosterone levels in patients with severe AV was higher than moderate and mild AV. No correlation between serum testosterone levels with AV severity in adult women. Further research ruled out confounding factors is needed to determine hormonal role in the pathogenesis of AV.

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