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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 7 Documents

Search results for , issue "Suppl. 2, No. 3 (2019)" : 7 Documents clear

Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch Wira Y. Rahman; Endang Sarmini; Herlina Herlina; Abidin Abidin; Triyanto Triyanto; Hambali Hambali; Sriyono Sriyono; Triani Widyaningrum
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumours. Currently, keloid is treated by a conventional method e.g.by applying the bulk of 32P radioisotope directly on keloid area. However, this method is considered inefficient and less secure. The purpose of this research is to obtain a technology for preparing of 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with particle size of <1 μm. These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily. Characterization of the prepared Cr32PO4colloids gave a yield of 97,8% with particle size of greater than > 1μm. Further study needs to be performed in due time in order to have Cr32PO4 colloids with a suitable particle size.Key words: keloid, chromic phosphate colloid, skin patch, condensation, oxidation-reduction reaction

99mTc-Human Serum Albumin-Nanoparticle for Sentinel Lymph Node Identification Rizky Juwita Sugiharti; Iim Halimah; Iswahyudi Iswahyudi; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

The sentinel lymph node is the first lymph node in a lymph node basin to receive lymphatic drainage from a primary tumor. An accurate identification and characterization of sentinel lymph node is very important as it helps to decide the extension of surgery, the tumor staging, and establisment of the most adequate therapy. Technetium-99m labeled Human Serum Albumin nanoparticle (99mTc-HSA nanoparticle) was prepare as a radiopharmaceutical with particle size between 100 - 200 nmthat is used in lymphoscintigraphy technique for tracinglymphatic system and identifies the sentinel lymph node. Biodistribution study of 99mTc-HSA nanoparticle was conducted in mice to identify the accumulation of this agent in sentinel node and the other tissue. 99mTc-HSA nanoparticle showed good accumulation in sentinel node about1.29 +0.90 %ID with value of popliteal extraction 89.55 +8.52 at one hour post injection. This result was indicated that 99mTc-HSA nanoparticle is very promising compound to be further explored as sentinel lymph node imaging agent.Key words: Lymphoscintigraphy, 99mTc-HSA-nanoparticle, sentinel lymph node

Integrity Test for Hepa Filters in Cleanroom Preparation and Cleanroom Process of Labled Compound I Wayan Widiana; Hermanto Hermanto
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

One of some factors that take effect for the cleanroom sterilization is the integrity of HEPA filters. The value of HEPA filters integrity should be contained in the qualification document of air conditioning system (HVAC). HEPA filters integrity testing aims to ensure the performance of HEPA filters that installed in the air conditioning system, so that no leakage occurs in the installation of HEPA filters, that cause the cleanroom becomes unsterile. The methodology used is to supply aerosol concentration in the upper HEPA filter between 10 - 100 μg/L, and then perform a maximum aerosol penetration measurement on the downstream of HEPA filter. The results are compared with the standard provisions that is contained in the "Procedural Standards for Certified Testing of Cleanrooms", where the maximum permissible penetration is 0.01%. The maximum value of aerosol penetration below 0.01%, that states a HEPA filter has good integrity. While the maximum value of aerosol penetration percentage above 0.01%, states that a HEPA filter has poor integrity. Integrrity test of HEPA filters was performed on 8 units, there are in the cleanroom preparation and cleanroom process of labled compound. The result obtained from the test is that all HEPA filter units have excellent integrity with maximum penetration percentage below 0.01%. The maximum aerosol penetration rate obtained from the overall HEPA filter is 0.004825 % ± 0.000707.Keywords: Labled Compound, Cleanroom, HEPA filter integrity, aerosol penetration

Evaluation of 99mTc-Ethambutol Radiopharmaceutical Using High Performance Liquid Chromatography with Radioactive Detector (Radio-HPLC) Maula Eka Sriyani; Rizky Juwita Sugiharti; Eva Maria Widyasari; Iim Halimah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

99mTc-ethambutol is a radiopharmaceuticals used to determine the location of Mycobacterium tuberculosisthat causes TB disease. To prepare this radiopharmaceuticals, several supporting compounds are required in addition to ethambutol and radionuclide compounds. These are mannitol as filler, SnCl2as a reducing agent and sodium pyrophosphate as co-ligand. The radiopharmaceuticals is made in the form of a lyophilized kit without 99mTc radionuclides. The aim of this study was to determined the effect of reducing agents on 99mTc-ethambutol preparation using the High Performance liquid chromatography (HPLC) equiped with radiodetector (radio-HPLC) to the quality of radiopharmaceuticals. In the previous study, the determination of radiochemical purity only used TLC by determining the amount of impurities TcO2and TcO4. This study was carried out more profoundly by using radio-HPLC to ensure the quality of radiopharmaceutical products that were made is actually 99mTc-ethambutol. The Test were performed using paper chromatography, electrophoresis, radio-HPLC, and stability test of 99mTc-ethambutol radiopharmaceuticals. The results showed that the radiopharmaceuticalkit of ethambutol is performing good physical characterictics and high radiochemical purity of 99mTc-ethambutol both in analysis using paper chromatography, electrophoresis and radio-HPLC. The 99mTc-ethambutol shown the peak at retention time (tr) 7,97 minutes using UV and radioactive detector, C18 column, isocratic system using phosphate buffer 0,2 M pH 7,4 and Acetonitrile (90 :10), flow rate 0,8 mL/min. The radiochemical purity of 99mTc-ethambutol is still remain high (91.44 ± 0.92%) after 27 days of kit were made.Key words: 99mTc-ethambutol, radio-HPLC, TB disease, Mycobacterium tuberculosis, radiopharmaceuticals.

Labeling of Piperine with Iodine-131 as Radiotracer in the Development of Cancer Drugs from Indonesia’s Natural Products Isti Daruwati; Yulia Anggraini; Aang Hanafiah Wangsaatmadja
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Piperine, as one of the secondary metabolites of pepper, shows many pharmacological activities in various studies, including as antiinflammatory, antimicrobial, hepatoprotective, antioxidant, and potentially anticancer agents. Cancer is still one of the leading causes of death in the world due to the absence of specific symptoms in early-stage of cancer. The development of drugs for early diagnosis and selective treatment of cancer cells is considered one of the best solutions to reduce mortality. The activity of piperine that could induce apoptosis of 4T1 breast cancer cells and HT-29 colon cancer cells at in vivo trials prove it as a potential compound that can carry radioactive atoms (as labeled-compound) to cancer cells. This study was conducted to determine the optimal conditions of labeling of piperine with iodine-131 in order to obtain a 131I-piperinewhich can later be used as a radiotracer in the development of cancer drugs. The labeling of piperine was performed by Chloramine-T iodination method and followed by purification with ion exchange chromatography. The optimal labeling results of piperine with 43.99% ± 1,23 radiochemical purity were obtained with piperine 3mg/300μL, chloramine-T 50 μg as an oxidizer, incubation time 30 min at room temperature, and 100 μg sodium metabisulphite as a reductor. To improve the purity of the preparation, purification by ion exchange chromatography method with Dowex 1x8 mesh 100-200 as resin was used until obtained 93,26% ± 0,94 of radiochemical purity. Further research is necessary before 131I-piperinecan be used as a radiotracer for cancer diagnosis in nuclear medicine.Keywords:cancer, iodine-131, 131I-piperine,labeled-compound, radiotracer

Software Development to Calculate Absorbed Dose Rate Distribution Using TG-43 Formula Ismet Isnaini; Wahyuni Z Imrana
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Radioisotope applications have become widespread in many fields, such as medical. For the optimal treatment using radioisotope, an accurate absorbed dose rate distribution calculation is required to provide the optimal dose for each patient. A software has been designed to calculate this absorbed dose rate distribution so that paramedics would know whether the absorbed dose rate distribution emitted from that particular source is sufficient or not. Using the TG-43 formula derived by American Association of Physicist in Medicine (AAPM), the calculation were performed using manufacturing data of the Ir-192 source and the function which involve the geometric position between the source and a calculation point. The results of this calculation which were viewed using the imageJ software, have shown that the absorbed dose rate for a source located in the center of a volume was getting larger near the source location but has decreased drastically at the source location.This is due to the unavailability of manufacturing data for radius less than 2.5 mm. As for absorbed dose rate distribution emitted from several sources, the dose rate accumulated and reached the maximum in the middle. It has also formed some sort of shape depending on the location of the source, which form an isodose line or curves.Keywords: TG-43 Formula, absorbed dose rate distribution

Profile of Occupational Dose at TRIGA 2000 Nuclear Facility Rini Heroe Oetami; Afida Ikawati; Dadang Supriatna
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Occupational dose is one of the safety parameters that must be verify to meet the safety objectives. Monitoring of occupational dose at TRIGA 2000 nuclear facility in 2015-2017 was performed using TLDs. The objectives of the monitoring were to evaluate and assess the occupational dose not to exceed the dose limit. In Technical and Health and Safety Division showed the maximum occupational dose for individual of 2.16 mSv and the highest collective dose of 0.029 man-Sv. The maximum occupational dose for individual in Reactor Division was of 1.48 mSv and the highest collective dose of 0.019 man-Sv. The maximum occupational dose for individual in Technophysic Division of 1.4 mSv and the highest collective dose of 0.017 man-Sv. In the Labeled Compound Division, the maximum occupational dose for individual of 2.59 mSv and the highest collective dose of 0.035 man-Sv . From the total of 82 radiation workers, the highest percentage of radiation workers received the occupational doses in the dose range of (1.01-1.50) mSv were: 50% (41 persons, in 2015), 85.36% (70 persons, in 2016) and 70.73% (58 persons, in 2017). 4 persons dose record were within of (2.01-2.50) mSv and 2 persons within of (2.51-3.00) mSv. No radiation worker received doses exceeded the annual dose limit of 20 mSv. Keywords: Occupational dose, Equivalent dose, Dose limit, Radiation worker

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Contact Name
Muchtaridi

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Journal Mail Official
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Kota bandung,

Jawa barat

INDONESIA