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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Articles 16 Documents
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Search results for , issue "Vol 4, No 2 (2015)" : 16 Documents clear
Ganoderma lucidum Polysaccharide Peptide (GLPP) for the Cancer Treatment Imam Rasjidi; Christine Susanto
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (49.177 KB) | DOI: 10.15416/ijcp.2015.4.2.120

Abstract

Ganoderma lucidum mushroom (also known as Ling Zhi in China, Mannetake /Reishi in Japan) has been widely used for thousands of years to prevent and treat various diseases, such as heart disease, diabetes mellitus, viral infection, and cancer. Polysaccharides from Ganoderma lucidum has been extensively investigated for free radical scavenging activity. Both in vivo and in vitro studies suggest that G. lucidum have anti-tumor effects, which mediated by its immunomodulatory, anti-angiogenesis, and cytotoxiceffects. Ganoderma lucidum polysaccharide peptide (GLPP) which extracted from Ganoderma lucidum mycelium tissue culture, give the best quality of β-D-Glucans bioactive compounds. These biologically active glucans interact with receptors on the surface of immune cells such as macrophage and natural killer cell (NK cell) to induce immunomodulatory and tumoricidal effects. However, many studies still need to answer those mechanisms.Key words: Anti-tumor effects, β-Glucan, Ganoderma lucidum, GLPP, immunomodulatory activityGanoderma lucidum Polysaccharide Peptide (GLPP)untuk Terapi KankerJamur Ganoderma lucidum (dikenal juga dengan nama Ling Zhi di China, atau disebut sebagai Mannetake/Reishi di Jepang) telah dimanfaatkan secara luas selama ribuan tahun untuk mencegah dan mengobati beragam penyakit, seperti penyakit jantung, diabetes melitus, infeksi virus, bahkan kanker. Polisakarida dari Ganoderma lucidum telah banyak diteliti untuk aktivitas radikal bebasnya. Baik studi in vivo maupun in vitro menyatakan G. lucidum memiliki efek anti tumor, yang dimediasi oleh aktivitas imunomodulator, anti-angiogenesi, dan sitotoksik. Ganoderma lucidum polysaccharide peptide (GLPP) yang diekstrak dari kultur jaringan miselium Ganoderma lucidum memberikan kualitas terbaik dari senyawa bioaktif β-D-glucans. Senyawa bioaktif glukans ini yang berinteraksi dengan reseptor di permukaan sel-sel imun, seperti makrofag dan NK cell yang dipercaya memberikan efek imunomodulator dan tumorisidal. Meskipun masih diperlukan banyak studi lanjutan untuk menjawab mekanisme dari GLPP.Kata kunci: Anti-tumor, β-Glucan, GLPP, Ganoderma lucidum, imunomodulator
Evaluasi Penggunaan Antibiotik pada Pasien Bedah di Suatu Rumah Sakit Swasta di Bandung Zulfan Zazuli; Elin Y. Sukandar; Ida Lisni
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.144 KB) | DOI: 10.15416/ijcp.2015.4.2.87

Abstract

Pemberian antibiotik prabedah dan pascabedah telah digunakan secara luas untuk menghindari dan menangani infeksi pada daerah pembedahan. Penggunaan antibiotik harus dievaluasi melalui program evaluasi penggunaan obat (EPO) untuk  menjamin penggunaan obat yang rasional. EPO antibiotik ini dilakukan berdasarkan pada kriteria penggunaan obat yang telah ditetapkan menggunakan studi data retrospektif dari bulan September sampai dengan November tahun 2009 untuk seluruh pasien bedah di salah satu rumah sakit swasta di Bandung. Telah dilakukan pemberian antibiotik sebanyak 1290 dosis yang terdiri atas pemberian antibiotik prabedah sebanyak 94 dosis dan pemberian antibiotik pascabedah sebanyak 1196 dosis. Telah terjadi ketidaktepatan penggunaan antibiotik yang terdiri atas ketidaktepatan indikasi sebesar 0,39%, dosis berlebih dan dosis kurang pada pemberian antibiotik pascabedah berturut-turut sebesar 2,26% dan 0,50%, ketidaktepatan waktu pemberian antibiotik prabedah sebesar 22,34%, interaksi obat sebesar 1,78% yang terdiri atas 0,46% interaksi farmakokinetik dan 1,31% interaksi farmakodinamik, serta duplikasi antibiotik sebesar 0,46%. Dapat disimpulkan bahwa terjadi beberapa ketidaktepatan penggunaan antibiotik. Ketidaktepatan yang paling besar terjadi pada ketidaktepatan waktu pemberian antibiotik prabedah. Dibutuhkan peran serta apoteker rumah sakit sebagai bagian dari upaya peningkatan ketepatan penggunaan antibiotik pada pasien bedah.Kata kunci: Antibiotik, evaluasi penggunaan obat, pembedahan, studi retrospektif Antibiotic Use Evaluation in Surgery Patients at a Private Hospital in BandungAntibiotic administrations in presurgery and postsurgery are widely used to avoid and to treat surgical site infections. In order to ensure the rational use of this drug, the use of antibiotic should be evaluated through drug use evaluation (DUE) programme. In this research, the DUE programme had been carried out based on predetermined criteria using restrospective data study from September until November 2009 to all surgery patients at a private hospital in Bandung. This research showed that 1290 doses antibiotic had been given to patients to treat surgical site infections, which were consist of 94 doses presurgery antibiotic and 1196 doses postsurgery antibiotics. This study showed the presence of inappropriate antibiotic uses that consists of 0.39% inappropriate indications; 2.26% overdoses and 0.50% subtherapy doses; 22.34% inappopriate administration timings of presurgery antibiotic; 1.78% drug interactions which 0.46% are pharmacokinetic drug interactions and 1.31% are pharmacodynamic drug interactions; and 0.46% antibiotic duplications. It can be concluded that there is some inappropriate use of antibiotics. The greatest inappropriateness is inappopriate administration timings of presurgery antibiotic. The role of the hospital pharmacist is needed as part of efforts to increse the appropriateness use of antibiotics in surgical patients.Key words: Antibiotic, drug use evaluation, restrospective study, surgery
Antagonis Reseptor Arginine Vasopressin: Harapan Baru dalam Penanganan Hiponatremia pada Pasien Gagal Jantung Saepudin Saepudin
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (616.802 KB) | DOI: 10.15416/ijcp.2015.4.2.129

Abstract

Pasien gagal jantung merupakan salah satu kelompok pasien yang memiliki risiko tinggi mengalami hiponatremia. Selain masalah diagnosis, permasalahan terapi juga banyak dijumpai dalam penanganan hiponatremia. Di tengah minimnya hasil uji klinis terapi konvensional untuk penanganan hiponatremia, hasil uji klinis obat-obat golongan antagonis reseptor arginine vasopressin atau yang dikenal dengan golongan vaptan membawa harapan baru untuk penanganan hiponatremia pada pasien gagal jantung. Tulisan ini merupakan hasil telaah pustaka terhadap artikel-artikel hasil penelitian dan pengkajian yang relevan yang ditelusuri dengan menggunakan kata kunci heart failure, hyponatremia, argininevasopressin, arginine-vasopressin receptor antagonist dan vaptan. Hasil uji klinis golongan vaptan pada pasien gagal jantung menunjukkan bahwa obat-obat tersebut secara efektif meningkatkan kadar natrium dalam darah dengan efek samping ringan yang umumnya dapat ditoleransi. Berdasarkan hasil uji klinis, conivaptan dan tolvaptan disetujui oleh Food and Drug Administration di Amerika untuk digunakan dalam penanganan hiponatremia pada pasien gagal jantung. Namun, banyak pakar mengajukan pertanyaan kritis terhadap hasil uji klinis obat-obat golongan vaptan ini dan masih meragukan penggunaannya untuk penanganan hiponatremia. Tulisan ini mengulas secara ringkas tentang hiponatremia pada pasien gagal jantung dan peran hormon arginine vasopressin (AVP), aspek farmakologi dan hasil uji klinis beberapa obat golongan vaptan, serta beberapa pertanyaan yang masih tersisa dari hasil uji klinis obat-obat tersebut.Kata kunci: Antagonis arginine vasopressin, arginine vasopressin, gagal jantung, hiponatremia, vaptanArginine-Vasopressin Receptor Antagonists: A New Hope for Treatment of Hyponatremia in Patients with Heart FailureHyponatremia is an important problem in patients with heart failure. It has also been known as a predictor both of short and long-term clinical outcome of heart failure patients. While evidences of clinical efficacy and safety of conventional options for treatment of hyponatremia resulted from clinical trials are very limited, several clinical trials have been conducted to evaluate the efficacy and safety of arginine vasopressin antagonists or also known as vaptan group. This paper reviews hyponatremia in patients with heart failure and the important roles of arginine vasopressin in its development, pharmacological aspects and clinical trials outcomes of some vaptans and several questions emerged from those clinical trials. Relevant research papers, reviews, and website information have been searched and included in this review using keyword of heart failure, hyponatremia, arginine-vasopressin, arginine-vasopressin receptor antagonist and vaptan. Generally, clinical trials have highlighted the efficacy and safety of vaptan groups in the management of hypervolemic hyponatremia in patients with heart failure. Those drugs can effectively increase serum sodium level with tolerable adverse reactions. Based on those clinical data two drugs of vaptan group, conivaptan and tolvaptan, have been approved by Food and Drug Administration in The United States to be used for the treatment of euvolemic and hypervolemic hyponatremia. However, many experts are still hesitant to recommend vaptans as treatment of choice for hyponatremia due to the lack of patients-focused outcomes measurements.Keywords: Arginine vasopressin antagonist, heart failure, hyponatremia, vaptan
Sterilitas Instrumen Pakai Ulang di Ruang Penyimpanan Unit Luka Bakar (ULB) Salah Satu Rumah Sakit di Kota Bandung Insan S. Kurniawansyah; Sohadi Warya; Hegandari S. Rahayu; Dionice L. Y. Putri
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7234.602 KB) | DOI: 10.15416/ijcp.2015.4.2.98

Abstract

apabila sterilitasnya tidak terjaga. Proses penyimpanan dan perlakuan terhadap instrumen pakai ulang adalah faktor utama dalam menjaga sterilitas instrumen. Prevalensi infeksi nosokomial di ruang unit luka bakar (ULB) salah satu rumah sakit di Kota Bandung ternyata cukup tinggi sehingga dilakukan penelitian mengenai sterilitas instrumen pakai ulang yang disimpan di ruangan tersebut. Penelitian ini bertujuan untuk dapat menekan angka kejadian infeksi nosokomial, yang salah satunya disebabkan oleh tidak sterilnya instrumen pakai ulang yang digunakan di ruang penyimpanan ULB yang akhirnya dapat menjamin keamanan atau keselamatan pasien. Metode penelitian yang digunakan adalah observasional laboratorik dengan tahapan yaitu penyiapan alat, bahan dan ruangan, pengujian sampel penelitian, dan analisis data. Hasil penelitian menunjukkan bahwa ruang penyimpanan ULB berpengaruh secara signifikan terhadap sterilitas instrumen pakai ulang, ruang CSSD 15,47 kali lebih steril dibanding ruang ULB. Adapun pengaruh lama penyimpanan terhadap sterilitas instrumen pakai ulang diketahui bahwa semakin lama waktu penyimpanan maka sterilitas instrumen semakin berkurang. Pihak rumah sakit diharapkan melakukan penyimpanan dan penggunaan instrumen di ULB tidak lebih dari tujuh hari sebagai usaha dalam mengurangi kejadian infeksi nosokomial di rumah sakit.Kata kunci: Infeksi nosokomial, instrumen pakai ulang, uji sterilitas, unit luka bakar (ULB)The Reusable Instrument Sterilities Stored in the Burn Care Unit at a Hospital in BandungReusable instruments may be a vector for the transmission of nosocomial infections if found contaminated or the sterility are not maintained. The process of storage and treatment towards the reusable instruments are the crucial factors to ensure the sterility of the reusable instruments. The prevalence of nosocomial in the Burns Unit (BU) at a Hospital in Bandung reveals outstanding values and thus has been chosen for this research. This research aimed to suppress the incidence of nosocomial infections, one of which is caused by not sterile of reusable instruments in the storage space BU which can get patient safety ultimately. The laboratory observational was used for this research with steps are preparing tools, materials and test room, sample test, and data analysis. The results found that the storage area in BU had a significant effect on the sterility of the instruments and it was deduced that the CSSD was 15.47 times more sterile than Burns Unit. Time of storage also affected the sterility of the instruments as it was found that the longer the storage time, the possibility of the reusable instruments remaining sterile are decreased. The hospital is expected to keep the instrument in ULB not more than seven days to efforts in reducing the incidence of nosocomial infections in hospitals.Key words: Burns unit (BU), nosocomial infection, reusable instrument, sterility test
Permasalahan Terkait Obat (Drug Related Problems/DRPs) pada Penatalaksanaan Penyakit Ginjal Kronis dengan Penyulit Penyakit Arteri Koroner Winda H. Furqani; Zulfan Zazuli; Nabilah Nadhif; Siti Saidah; Rizky Abdulah; Keri Lestari
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2487.813 KB) | DOI: 10.15416/ijcp.2015.4.2.141

Abstract

Masalah terkait obat (DRPs) didefinisikan sebagai setiap kondisi dalam penatalaksanaan terapi pasien yang menyebabkan atau berpotensi menyebabkan tidak tercapainya hasil terapi yang optimal. Penelitian ini dilakukan di salah satu rumah sakit di Kota Cimahi pada bulan Mei 2014. Pada penelitian ini dilakukan identifikasi DRPs pada pasien wanita berusia 59 tahun yang didiagnosis penyakit ginjal kronis dengan penyulit penyakit arteri koroner dan gangren di tangan kiri (jari ke-3). Pasien diketahui mempunyai riwayat diabetes melitus sejak dua hingga tiga tahun yang lalu. Melalui kajian DRPs ditemukan permasalahan terkait obat, yaitu adanya terapi obat yang tidak diperlukan (pemberian kalsium polistiren sulfonat), ketidaktepatan pemilihan antibiotik, Ketidaktepatan dosis (pemberian amoksisilin dan kaptopril), dan risiko interaksi obat-obat merugikan (interaksi kaptopril–furosemid, kaptopril–isosorbid dinitrat, dan kaptopril–natrium bikarbonat). Pasien penyakit ginjal kronis dengan penyulit penyakit arteri koroner menerima terapi obat yang kompleks sehingga meningkatkan risiko terjadinya DRPs. Keterlibatan apoteker klinis di rumah sakit dalam penatalaksanaan penyakit yang kompleks diperlukan untuk mengoptimalkan terapi, meminimalisir risiko DRPs, dan meningkatkan kualitas hidup pasien.Kata kunci: Drug related problems, penyakit ginjal kronis, penyakit arteri koronerDrug Related Problems in the Management of Chronic Kidney Disease with Coronary Artery DiseaseDrug related problems were defined as conditions on patient’s therapy management that caused, or potentially caused unsuccessful therapy. This study was conducted at a hospital in Cimahi City in May 2014. In this study, DRPs were identified on a 59 years old woman who was diagnosed with chronic kidney disease and coronary artery disease with gangrene on the left hand (the third finger). The patient also had a diabetes mellitus for two until three years ago. Drug related problems (DRPs) were found in this patient. Unnecessary drug therapy (administration of calsium polystirene sulfonate), inappropriate choosen antibiotic, inappropriate dosing (administration of amoxicillin and captopril), and risks drug interactions (captopril–furosemide, captopril–isosorbide dinitrate, and captopril–sodium bicarbonate). Patients with chronic kidney disease and coronary artery disease received complex drug therapy. These condition lead to higer risk of DRPs. The involvement of clinical pharmacist in interdisciplinary team for management of complex diseases was needed to monitor drug therapy to optimizing the therapy, minimalizing the risk of DRPs, and improving patient’s quality of life.Key words: Chronic kidney disease, coronary artery disease, drug related problems
Evaluasi Nilai Antigen Squamous Cell Carcinoma Pasien Kanker Serviks Sel Skuamosa Stadium II B–III B yang Menerima Kemoterapi Bleomisin, Oncovin®, Mitomisin, dan Cisplatin Rini Noviyani; Ketut Suwiyoga; Intan Puspa; Nyoman Budiana; Ketut Tunas
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.348 KB) | DOI: 10.15416/ijcp.2015.4.2.106

Abstract

Kemoterapi Bleomisin, Oncovin®, Mitomisin, dan Cisplatin (BOMP) merupakan salah satu tatalaksana terapi untuk kanker serviks. Penelitian ini bertujuan mengevaluasi respons kemoterapi regimen BOMP pada pasien kanker serviks sel skuamosa stadium IIB–IIIB dengan antigen SCC. Pada penelitian potong lintang prospective ini diperoleh 12 pasien kanker serviks yang memenuhi kriteria inklusi yang diambil dengan metode consecutive sampling. Pemeriksaan kadar antigen SCC dilakukan dengan cara mengambil darah pasien sebelum kemoterapi BOMP seri pertama dan sesudah kemoterapi BOMP seri ketiga kemudian diperiksa dengan alat ARCHITECT SCC assay. Data dianalisis menggunakan paired test dengan interval kepercayaan 95%. Terdapat penurunan rerata nilai antigen SCC pada penderita kanker serviks tipe sel skuamosa setelah tiga seri kemoterapi BOMP meskipun penurunan tersebut tidak bermakna secara statistik (p>0,05). Perbedaan yang tidak bermakna secara statistik ini mungkin disebabkan kurangnya jumlah pasien yang digunakan. Hasil penelitian ini dapat digunakan oleh dokter sebagai pertimbangan untuk melanjutkan kemoterapi BOMP hingga seri keenam sesuai dengan prosedur yang diberlakukan dengan pemantauan rutin terhadap kondisi pasien khususnya nilai antigen SCC untuk untuk memprediksi prognosis dan respons kemoterapi.Kata kunci: Antigen SCC, BOMP, kanker serviks sel skuamosa, kemoterapi, stadium IIB–IIIBEvaluation of Squamous Cell Carcinoma Antigen Value in Stadium IIB–IIIB Squamous Cell Cervical Cancer Patients which Receiving Bleomycin, Oncovin®, Mitomycin, and Cisplatin ChemotherapyBleomycin, Oncovin®, mitomycin, and cisplatin (BOMP) chemotherapy is one of the management of cervical cancer therapy. The aim of this study was to evaluate the response to BOMP chemotherapy regimens in patients squamous cell cervical cancer stage IIB-IIIB using SCC antigen. In this prospective cross sectional study was obtained 12 cervical cancer patients who met the inclusion criteria, which is taken by using consecutive sampling method. Examination of SCC antigen levels was conducted by taking a patient’s blood before the first series and after the third series of BOMP chemotherapy, then further examined by ARCHITECT SCC assay. Data were analyzed using paired test with 95% confidence intervals. Statistical analysis showed that there were a decrease in the average value of SCC antigen in patients with squamous cell cervical cancer types after 3 series of BOMP chemotherapy although this reduction was not statistically significant (p>0.05). The differences are not statistically significant is probably due to insufficient number of patients used in this study. The doctor may consider to continue chemotherapy until the sixth series in accordance with the procedures by routine monitoring of the patient’s condition, especially SCC antigen values for predicting the prognosis and response of chemotherapy.Key words: BOMP, chemotherapy, SCC antigen, squamous cell of cervical cancer, stadium IIB–IIIB

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