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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Analisis Minimalisasi Biaya Terapi Antihipertensi dengan Kaptopril-Hidroklorotiazid dan Amlodipin-Hidroklorotiazid di Salah Satu Rumah Sakit Kota Bandung Andini Faramitha; Budhi Prihartanto; Dika P. Destiani
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2564.543 KB) | DOI: 10.15416/ijcp.2017.6.3.220

Abstract

Keberhasilan terapi hipertensi stage 2 dapat ditunjang dengan adanya pemberian antihipertensi. Beragamnya alternatif terapi antihipertensi menjadikan studi farmakoekonomi diperlukan agar diperoleh terapi yang efektif dan efisien. Tujuan penelitian ini adalah untuk mencari kelompok kombinasi antihipertensi yang lebih efisien dalam hal biaya (minimalisasi biaya) yang digunakan pada pasien hipertensi stage 2 yang dirawat di salah satu rumah sakit swasta Kota Bandung periode tahun 2011–2013. Penelitian ini merupakan studi observasional dengan pengumpulan data secara retrospektif. Pengambilan data dilakukan dengan mengambil rekam medis pasien rawat inap hipertensi stage 2 dan mendapat terapi antihipertensi kaptopril-hidroklorotiazid dan amlodipin-hidroklorotiazid. Komponen biaya yang dikumpulkan meliputi biaya antihipertensi, biaya tindakan, biaya penunjang, biaya rawat inap dan biaya administrasi. Hasil penelitian menunjukkan bahwa total biaya perawatan kombinasi antihipertensi kaptopril-hidroklorotiazid lebih rendah dibandingkan amlodipin-hidroklorotiazid, dengan selisih sebesar Rp126.798.Kata kunci: Antihipertensi, biaya minimal, farmakoekonomi, hipertensiCost Minimization Analysis of Antihypertensive Therapy with Captopril-Hydrochlorothiazide and Amlodipine-Hydrochlorothiazide in One of Hospitals in BandungThe successful therapy of stage 2 hypertension  can be supported by the administration of antihypertensive. Existence of various antihypertensive alternative making pharmacoeconomics study is needed in order to have an effective and efficient therapy. Purpose of this study was to find the antihypertensive group therapy which is more efficient in cost (cost minimization) which used in the treatment of stage 2 hypertension in patients at one hospital in Bandung from 2011 until 2013. This study is an observational reserach with retrospective data collection. Data retrieval was done by taking the medical records of hospitalized patients who received therapy of stage 2 hypertension antihypertensive, captopril-hydrochlorothiazide or amlodipin-hydrochlorothiazide. Components that were collected includes the cost of antihypertensive, supportive therapy costs, the cost of action, administrative expenses and cost of hospitalization. The result of this study of cost minimization analysis showed that the total cost of treatment with the antihypertensive captopril-hydrochlorothiazide is lower compared to amlodipin- hydrochlorothiazide, with the difference amounting to Rp126,798.Keywords: Antihypertensive, cost minimization, pharmacoeconomy, hypertension
Pengaruh Pemberian Steroid sebagai Terapi Tambahan terhadap Rata-Rata Lama Pasien Dirawat di Rumah Sakit dan Tanda Klinis pada Anak dengan Pneumonia Sulistia Ardyati; Nurcholid U. Kurniawan; Endang Darmawan
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.586 KB) | DOI: 10.15416/ijcp.2017.6.3.181

Abstract

Terapi steroid pada anak dengan pneumonia merupakan terapi tambahan yang memiliki aktivitas sebagai penghambat inflamasi yang menekan ekspresi sitokin proinflamasi dan berpotensi mencegah respon inflamasi. Beberapa penelitian menunjukkan pemberian steroid tidak memberikan pengaruh dalam pengobatan pada pasien pneumonia, tetapi pada penelitian lain menunjukkan pemberian steroid mengurangi rata-rata lamanya pasien dirawat di rumah sakit. Tujuan dari penelitian ini adalah untuk melihat pengaruh pemberian steroid terhadap rata-rata lamanya pasien dirawat di rumah sakit (LoS) dan tanda klinis pasien anak dengan pneumonia. Penelitian yang dilakukan merupakan penelitian observasional dengan metode prospektif yang dilakukan di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta pada bulan September 2015 hingga Januari 2016. Lima puluh satu pasien digunakan sebagai subjek penelitian. Penelitian ini terdiri dari 2 kelompok yakni kelompok non-steroid terdiri dari 25 pasien dan kelompok steroid terdiri dari 26 pasien. Kelompok non-steroid dan steroid masing-masing memiliki nilai rata-rata lamanya pasien dirawat di rumah sakit 5 (3–10) hari dan 4 (3–10) hari. Durasi tanda klinis pasien kelompok steroid dan kelompok non-steroid berturut-turut adalah 2 (0–6) hari dan 2 (0–7) hari untuk demam, batuk 4 (1–10) hari dan 5 (2–10) hari, sesak 1 (0–5) hari dan 1 (0–10) hari, retraksi 1 (0–5) hari dan 1 (0–9) hari. Kesimpulan dari penelitian ini adalah steroid sebagai terapi tambahan memberikan efek yang tidak berbeda bermakna terhadap nilai length of stay dan tanda klinis pasien anak dengan pneumonia.Kata kunci: Anak, length of stay, pneumonia, steroid Steroids Effect as Adjuvant Therapy toward Length of Stay and Clinical Symptoms in Pediatric with PneumoniaSteroid therapy in children with pneumonia is an adjuvant therapy that has inhibitor inflammatory activity which can suppress the expression of proinflammatory cytokines and potentially prevent the inflammatory response. Some studies showed that steroids did not give beneficial effects in the treatment of patients with pneumonia, while the other studies showed that steroids can reduce the length of stay in hospital. The purpose of this study was to observe the effect of steroid on the length of stay and clinical symptoms in pediatric patients with pneumonia. This was an observational study with a prospective method in patients with pneumonia in PKU Muhammadiyah Bantul Hospital Yogyakarta from September 2015 until January 2016. Fifty one patients participated as subjects of this study. This study consisted of two groups, which were non-steroid group (n=25) and steroid group (n=26). Group of non-steroid and steroid had average value of length of stay of 5 (3–10) days and 4 (3–10) days, respectively. The duration of clinical symptoms of patients in the steroid and non-steroid group in a row was 2 (0–6) days and 2 (0–7) days for symptoms of fever, 4 (1–10) days and 5 (2–10) days for symptoms of cough, 1 (0–5) days and 1 (0–10) days for symptoms of shortness, and 1 (0–5) days and 1 (0–9) days for symptoms of retraction. The conclusion of this study is steroid has not given significant effects on the length of stay and clinical symptoms in pediatric patients with pneumonia.Keywords: Length of stay, pediatric, pneumonia, steroid
Illness Perceptions and Quality of Life in Patients with Diabetes Mellitus Type 2 Dyah A. Perwitasari; Setiyo B. Santosa; Imaniar N. Faridah; Adrian A. Kaptein
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2429.99 KB) | DOI: 10.15416/ijcp.2017.6.3.190

Abstract

One of the treatment objectives in patients with type 2 diabetes mellitus (T2DM) is improving their quality of life (QoL). Illness perceptions are major determinant of QOL. This study was aimed to evaluate the QoL of T2DM patients with complications, and to examine the correlation between patients’ illness perceptions and QoL. We conducted a cross-sectional study in a private hospital in Yogyakarta, Indonesia from July to September 2015. We recruited adult patients with a diagnosis of T2DM with complications (ICD E.11) that has been diagnosed for at least 3 months. Illness perceptions were assessed with the Brief Illness Perception Questionnaire (BIPQ), and diabetes type 2 specific QoL with the Diabetes Quality of Life for Clinical Trial Questionnaire (DQLCTQ). Data was analyzed using Pearson correlation test. We recruited 51 T2DM patients. Female patients were dominant and most of the subjects experienced T2DM more than 5 years. The BIPQ scores indicated that patients had positive perceptions about T2DM and the treatment in all domains, except for coherence. Scores on the DQLCTQ showed that T2DM patients’ QoL is good, except for the self satisfaction and treatment effect. Statistically significant positive correlations were observed between BIPQ dimensions of personal control, treatment control and coherence and QoL domains (p<0.01). Moreover, the strong negative correlation were observed between consequences, concern and emotional response and QoL domains (p<0.01). However, 92% correlations are weak. Illness perceptions are correlated with T2DM patients’ QoL. Interventions aimed to get more adaptive illness perceptions may impact positively on QoL.Keywords: BIPQ, DQLCTQ, illness perceptions, Indonesia, QoL, T2DM Persepsi terhadap Penyakit dan Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Salah satu tujuan terapi DM tipe 2 adalah memperbaiki kualitas hidup pasien. Persepsi terhadap penyakit merupakan penentu utama dari kualitas hidup. Tujuan penelitian ini adalah untuk mengevaluasi kualitas hidup pasien pada pasien DM tipe 2 dengan komplikasi serta mengetahui hubungan antara persepsi pasien dan kualitas hidup. Rancangan penelitian ini adalah potong lintang yang dilakukan di rumah sakit swasta di Yogyakarta. Subjek yang berpartisipasi dalam penelitian ini adalah pasien DM tipe 2 dewasa dengan komplikasi yang terdiagnosa minimal 3 bulan sebelum penelitian ini dimulai (ICD E11). Kualitas hidup diukur dengan Diabetes Quality of Life for Clinical Trial Questionnaire (DQLCTQ) dan persepsi pasien diukur dengan Brief Illness Perception Questionnaire (BIPQ). Sejumlah 51 pasien DM tipe 2 dengan komplikasi turut berpartisipasi dalam penelitian ini dari bulan Juli sampai September 2015. Mayoritas subjek adalah wanita dan sebagian besar pasien mengalami DM tipe 2 lebih dari 5 tahun. Skor domain BIPQ memperlihatkan bahwa pasien DM tipe 2 mempunyai persepsi yang positif terhadap penyakit dan pengobatannya pada semua domain kecuali koherensi. Skor domain DQLCTQ memperlihatkan bahwa pasien mempunyai kualitas hidup yang baik, kecuali domain kepuasan pribadi dan efek terapi (berturut-turut 55,6 dan 44,3). Korelasi kuat yang positif terlihat pada domain persepsi kontrol diri, kontrol terapi dan koherensi dengan semua domain kualitas hidup (p<0,01). Korelasi kuat yang negatif terlihat pada domain konsekuensi, kekhawatiran dan respon emosi dengan kualitas hidup (p<0,01). Sejumlah 92% korelasi BIPQ dan DQLCTQ adalah lemah. Persepsi pasien dan komplikasi dapat memengaruhi kualitas hidup pasien DM tipe 2. Intervensi yang bersifat memperbaiki persepsi pasien akan berdampak positif terhadap kualitas hidup.Kata kunci: BIPQ, DM tipe 2, DQLCTQ, Indonesia, kualitas hidup, persepsi
Effect of Calcium Supplementation During Pregnancy in Maternal Patient to Preterm Birth in One of Private Hospitals in Yogyakarta Albertus I. Brilian; Dita Maria Virginia
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.707 KB) | DOI: 10.15416/ijcp.2017.6.3.153

Abstract

Calcium is one of micronutrients that plays an important role in pregnancy. Insufficient consumption of calcium in pregnant women could lead to preterm birth, which is a major cause of neonatal mortality. This study aimed to determine the maternal patients’ characteristics, relationship between prematurity risk factors such as age, antenatal care, history of abortion and parity as well as calcium supplementation during pregnancy on pregnant women toward preterm birth in one of private hospitals in Yogyakarta. The survey was conducted from May to August 2016 The study was an analytical observation with cross‑sectional research design. In total of 199 medical records of maternal patients that had been included were analyzed using Mann-Whitney and Chi-Square test to see the relationship of calcium supplementation to preterm birth. Fisher’s exact test was used if Chi-Square’s requirement was not fulfilled. The pregnant women’s characteristics in the hospital were expectant mothers with normal gestational age (93%); insufficient calcium supplementation (79%); age ≤30 years (61%); bachelor’s degree (53%); private employees (40%); antenatal care ≥4 (98%) and parity 1 and ≥4 (54%). The result of this study showed there was no relationship between age, antenatal care, history of abortion and parity as well as calcium supplementation toward preterm birth on pregnant women in one of private hospitals in Yogyakarta.Keywords: Calcium supplementation, maternal, preterm birth Pengaruh Suplementasi Kalsium pada Pasien Maternal Selama Kehamilan terhadap Kelahiran Prematur di Salah Satu Rumah Sakit Swasta di YogyakartaKalsium merupakan salah satu mikronutrien yang memainkan peran penting pada masa kehamilan. Pengonsumsian kalsium yang kurang pada ibu hamil dapat menyebabkan kelahiran prematur (kelahiran <37 minggu) yakni penyebab utama kematian neonatal. Penelitian ini bertujuan untuk mengetahui karakteristik pasien maternal, hubungan faktor-faktor risiko seperti antenatal care, umur, riwayat abortus dan paritas serta suplementasi kalsium selama kehamilan terhadap kelahiran prematur di salah satu rumah sakit swasta di Yogyakarta. Penelitian ini dilakukan pada bulan Mei hingga Agustus 2016. Jenis penelitian ini adalah analitik observasional dengan rancangan cross-sectional. Sebanyak 199 rekam medis pasien maternal yang masuk dalam kriteri inklusi dianalisis menggunakan uji Mann-Whitney dan uji Chi-Square. Uji Fisher digunakan apabila syarat uji Chi-Square tidak terpenuhi. Karakteristik pasien maternal di salah satu rumah sakit swasta di Yogyakarta yaitu minggu kelahiran normal (93%), suplementasi kalsium tidak sesuai (79%), umur ≤30 tahun (61%), tingkat pendidikan strata satu (53%), pekerjaan pegawai swasta (40%), antenatal care ≥4 kali (98%) dan paritas 1 dan ≥4 kali (54%). Hasil penelitian ini mengungkapkan tidak terdapatnya hubungan antara umur, antenatal care, riwayat abortus dan paritas serta suplemen kalsium (p>0,05) terhadap kelahiran prematur pada pasien maternal di salah satu rumah sakit swasta di Yogyakarta.Kata kunci: Kelahiran prematur, maternal, suplementasi kalsium
Evaluasi Kualitas Hidup Responden Hipertensi Usia 40–75 Tahun Menggunakan Instrumen SF-36 di Kecamatan Kalasan, Sleman, DIY Fransisca Melani; Kresensia T. Hasrat; Bonifasia A. C. Widyasti; Rita Suhadi
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (731.164 KB) | DOI: 10.15416/ijcp.2017.6.3.200

Abstract

Hipertensi merupakan kondisi peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Status kesehatan yang buruk menunjukkan kualitas hidup yang buruk. Faktor-faktor yang dapat memengaruhi kualitas hidup adalah umur, pendidikan, penghasilan, BMI dan jenis kelamin. Tujuan dari penelitian ini adalah mengevaluasi perbedaan faktor risiko kesehatan dan faktor sosioekonomi dari kualitas hidup responden hipertensi di Kecamatan Kalasan, Sleman. Jenis penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Responden dalam penelitian ini adalah penduduk usia 40–75 tahun. Pengambilan sampel dilakukan di 4 dukuh di Kecamatan Kalasan, yaitu Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, dan Padukuhan Dhuri. Analisis data dilakukan dengan uji normalitas Kolmogorov-Smirnov, dilanjutkan dengan uji-t tidak berpasangan untuk masing-masing delapan domain kualitas hidup SF-36 dengan faktor risiko kesehatan dan sosioekonomi. Hasil penelitian menunjukkan pada faktor risiko kesehatan yaitu perbedaan kelompok usia memengaruhi kualitas hidup pada komponen kesehatan fisik (p<0,05), aspek fungsi fisik (p<0,05) dan peran fisik (p<0,05). Variabel sosioekonomi dari aspek sosioekonomi memengaruhi kualitas hidup pada komponen kesehatan mental (p<0,05) terkait aspek peran emosi (p<0,05) dan komponen kesehatan fisik (p<0,05) terkait aspek fungsi fisik (p<0,05) serta aspek peran fisik (p<0,05).Kata kunci: Hipertensi, kualitas hidup, risiko kesehatan dan sosioekonomiQuality of Life Evaluation of Respondents with Hypertension Aged 40–75 Years Using SF-36 Instruments in Kalasan District, Sleman, Yogyakarta ProvinceHypertension is a condition of an increase of systolic blood pressure over 140 mmHg and diastolic blood pressure over 90 mmHg. Poor health status indicates poor quality of life. There are many factors that may affect the quality of life, such as age, education, income, Body Mass Index (BMI) and sex. The purpose of this study was to evaluate the differences of health risk factors and socioeconomic factors on the quality of life of respondents with hypertension in Kalasan District, Sleman. This type of research is an observational study with cross-sectional approach. Respondents in this study were the people aged 40–75 years. Sampling was conducted in four hamlets in Kalasan District, named Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, and Padukuhan Dhuri. The data analysis was performed with Kolmogorov-Smirnov normality test, followed by t-independent test for each of the eight domains of quality of life with the SF-36 health and socioeconomic risk factors. The results from health risk factors showed that the difference of age affected quality of life on physical health component (p<0.05), physical function aspect (p<0.05) and physical role (p<0.05). Socioeconomic aspects of socioeconomic variables affected the quality of life on the mental health component (p<0.05), related to the role of emotions aspect (p<0.05) and physical health component (p<0.05) related to physical function aspect (p<0.05) also the physical role aspect (p<0.05).Keywords: Health and socioeconomic risk factors, hypertension, quality of life
Efek Kemoterapi Bleomisin, Vincristin, Mitomisin dan Karboplatin terhadap Massa Tumor dan Infiltrasi Parametrium pada Pasien Kanker Serviks: Studi Kasus di RSUP Sanglah Denpasar Rini Noviyani; I Nyoman G. Budiana; I Ketut Tunas; Ayu Indrayathi; Rasmaya Niruri; Ketut Suwiyoga
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.937 KB) | DOI: 10.15416/ijcp.2017.6.3.164

Abstract

Penggunaan regimen BOM-cisplatin untuk kemoterapi pasien kanker serviks masih belum memberikan hasil efektivitas yang memuaskan, sehingga dilakukan penggantian agen cisplatin dengan karboplatin. Kemoterapi BOM-karboplatin merupakan salah satu regimen terapi kanker serviks di RSUP Sanglah Denpasar. Informasi tentang efektivitas penggunaan BOM-karboplatin untuk kemoterapi kanker serviks masih sangat minim, maka dari itu penelitian ini dilakukan dengan melihat massa tumor dan infiltrasi parametrium. Penelitian ini merupakan penelitian studi kasus terhadap 9 pasien kanker serviks sel skuamosa stadium IIB–IIIB sebelum dan sesudah kemoterapi BOM-karboplatin di RSUP Sanglah dari bulan Februari hingga Agustus 2015 yang memenuhi kriteria. Pemeriksaan Massa Tumor dan Infiltrasi Parametrium (%CFS) dilakukan sebelum kemoterapi seri I dan sesudah kemoterapi seri III. Pengambilan sampel menggunakan consecutive sampling. Data penelitian dianalisis menggunakan uji normalitas yaitu uji Shapiro-Wilk, selanjutnya dianalisis menggunakan uji t berpasangan dengan taraf kepercayaan 95%, sedangkan data berdistribusi tidak normal ditranformasi ke bentuk fungsi logaritma lalu dianalisis dengan uji Wilcoxon. Berdasarkan analisis statistik diketahui bahwa terdapat penurunan bermakna pada massa tumor dan infiltrasi parametrium kiri sesudah 3 seri kemoterapi dengan nilai p<0,05 yaitu masing-masing p=0,001 dan p=0,025, tetapi tidak terdapat penurunan bermakna pada infiltrasi parametrium kanan dengan nilai p>0.05 yaitu p>0,083.Kata kunci: BOM-cisplatin, cancer free space, kanker serviks, RSUP Sanglah Effect of Chemotherapy Bleomycin, Vincristin, Mitomycin and Carboplatin by Tumor Mass and Infiltration Parametrial for Cervical Cancer Patients: Case Study in Sanglah General Hospital, DenpasarBOM-cisplatin regimen for chemotherapy for cervical cancer patients has not resulted high efficacy, hence a replacement of cisplatin with carboplatin is proposed. BOM-carboplatin chemotherapy is at present a treatment for cervical cancer patients in Sanglah Hospital in Denpasar. Information about the efficacy of using the BOM-carboplatin for cervical cancer chemotherapy is not provided, therefore this research performed by observing tumor mass and parametrial infiltration. This research was carried out using case study method on 9 patients with squamous cell cervical cancer stage IIB–IIIB before and after BOM-carboplatin chemotherapy at Sanglah Hospital from February until August 2015. Examination of tumor mass and parametrial infiltration (%CFS) conducted prior to chemotherapy series I and after chemotherapy series III. Sampling was done consecutively. The research data were analyzed using the normal distribution Shapiro-Wilk test continued by paired t-test with 95% confidence level, while data that is classified otherwise is transformed to logarithmic function and were analyzed using the Wilcoxon test. Based on statistical analysis, there is significant reduction in tumor mass and left parametrial infiltration after the third chemotherapy with (p<0.05) which are p=0.001 and p=0.025, but there is no significant reduction of right parametrial infiltration with p>0.05 that is p>0,083.Keywords: BOM-cisplatin, cancer free space, cervix cancer, Sanglah hospital

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