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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
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Articles 2 Documents
Search results for , issue " Vol 13, No 3 (2013)" : 2 Documents clear
Hubungan Derajat Kepositifan TUBEX TF dengan Angka Leukosit pada Pasien Demam Tifoid Nazilah, Amalia Afiyatun; Suryanto, Suryanto
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 3 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Demam tifoid adalah suatu penyakit infeksi sistemik akut yang disebabkan oleh bakteri Salmonella typhi. Salah satu pemeriksaan penunjang untuk diagnosis demam tifoid dengan menggunakan uji serologi TUBEX TF yaitu pemeriksaan diagnostik in vitrosemikuantitatif untuk mendeteksi demam tifoid akut, melalui deteksi spesifik adanya serum antibodi IgM terhadap antigen S. typhi O9 lipopolisakarida. Penelitian ini bertujuan untuk mengetahui hubungan derajat kepositifan TUBEX TF terhadap angka leukosit pada pasien demam tifoid. Jenis penelitian adalah observasional analitik untuk mengetahui hubungan derajat kepositifan TUBEX TF terhadap angka leukosit pada pasien demam tifoid dengan desain cross-sectional. Data diambil dari rekam medis RS PKU Muhammadiyah Yogyakarta periode Januari 2011-April 2012, didapatkan 86 pasien yang memenuhi kriteria inklusi dan ekslusi dari penelitian ini. Berdasarkan perhitungan statistik dengan uji Spearman didapatkan nilai p = 0,781 (p>0,05) dan nilai correlation coefficient -0,030 yang menunjukkan hubungannya sangat lemah dengan arah korelasi negatif. Disimpulkan bahwa tidak terdapat hubungan yang bermakna antara derajat kepositifan TUBEX TF terhadap angka leukosit pada pasien demam tifoid.Typhoid fever is an acute systemic infection disease caused by Salmonella typhi. One of the inves­tigations for the diagnosis of typhoid fever by using serological test TUBEX TF, is an in vitro diagnostic examination semiquantitatively to detect acute typhoid fever, through the specific detection of serum IgM antibodies toward the antigen S. typhi O9 lipopolysaccharide. This research aims to determine the relation between degree positivity of TUBEX TF toward leukocytes count in patients with typhoid fever. This re­search is observational analytic with cross-sectional design to know relation between degree positivity of TUBEX TF toward leukocytes count in patients with typhoid fever. Data retrieved from the medical records RS PKU Muhammadiyah Yogyakarta period January 2011-April 2012, found 86 patients who fill up the inclusion and exclusion criteria of the study. Based on statistical calculations obtained with the Spearman test p=0.781 (p> 0.05) and the correlation coefficient value is -0.030 indicating very weak relation with direction of the negative correlation. It can concluded that there was no significant relation between degree positivity of TUBEX TF toward leukocytes count in patients with typhoid fever.
Bubuk Cinnamon burmani Menurunkan Kadar Glukosa Darah pada Tikus Putih Diabetik Diinduksi Alloxan Tusara, Giand Elmadahlia; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 3 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Bubuk kayu manis mengandung flavonoid yang memiliki efek hipoglikemik untuk menurunkan kadar gula darah. Tujuan penelitian ini adalah untuk mengetahui efek pemberian bubuk kayu manis (Cinnamon burmani) terhadap kadar gula darah pada tikus diabetes diinduksi alloxan. Penelitian ini adalah penelitian eksperimental laboratorium dengan rancangan penelitian pre and post tets control design menggunakan 18 tikus yang dibagi menjadi 3 kelompok, masing-masing terdiri 6 ekor tikus. Kelompok pertama tidak diberikan perlakuan, kelompok kedua diberi bubuk C. burmani3,6 mg/hari dan kelompok ketiga diberi bubuk C. burmani7,2 mg/hari. Tikus di kelompok 2 dan 3 diberi bubuk C. burmani setiap hari selama 21 hari. Data yang diperoleh dianalisis menggunakan ANOVA satu jalan dilanjutkan dengan uji post-hoc Tukey HSD. Hasil uji menunjukkan bahwa pemberian bubuk C. burmani memberikan efek penurunan gula darah berrmakna (p< 0.05). Dosis terbaik untuk menurunkan kadar gula darah dalam penelitian ini adalah 7,2 mg/day setelah pemberian selama 21 hari. Pemberian dosis 2 kali lipat tidak menyebabkan kecepatan penurunan gula darah 2 kali lipat juga. Disimpulkan bahwa pemberian bubuk C. burmani dapat menurunkan kadar glukosa darah pada tikus putih diabetik yang diinduksi alloxan.Cinnamon powder contain flavonoid as antioxidant and MHCP (methylhydroxy-chalcone poly­mer) which provide hypoglycemic effect to reduce level blood glucose. The aim of this study is to know the effect of cinnamon powder (Cinnamon burmani) given to the blood glucose in alloxan-induced dia­betic rats. This research was an experimental laboratory with pre and post tets control design using 18 rats were divided into three groups, each group were 6 rats. The first group were not given anything, the second group were given cinnamon powder 3,6 mg/day and the third were given cinnamon powder 7,2 mg/day. Rats in group 2 and 3 were given cinnamon powder everyday for 21 days. Hypoglycemic activity was evaluated at day 0, 7, 14 and 21. The data was compared statistically using one-way analysis of variance (ANOVA) followed by post-hoc test Tukey HSD. The result indicated that cinnamon powder giving significant effect on the reduction of blood glucose. In this research were used the optimum doses to decreasing blood glucose level at 7,2 mg/day after 21 days treatment The double doses cannot also decreasing speed of blood glucose causes. It was concluded that C. Burmani powder can decrease blood glucose levels in diabetic mice induced alloxan.

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