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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue " Vol 4, No 1 (2004)" : 2 Documents clear
Anestesi pada Operasi Palatoplasty dengan Penyulit Tetralogy of Fallot Munandar, Arief
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2004)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Di laporkan penatalaksanaan anestesi pada pasien Labiopalatoschisis dengan penyulit Tetralogy of Fallot yang dilakukan operasi palatoplasti pada seorang anak wanita umur 4 tahun, berat badan 9 kg, dengan anestesi umum, status fisik ASA III. Premedikasi dengan midazolam 0,75 mg, sulfas atropin 0,25 mg, ketalar 5 mg. Induksi dengan ketalar 15 mg, fasilitas intubasi dengan Esmeron 6 mg. Pemeliharaan dengan fentanil 20 mg, halotan 0,5% dan oksigen 5 1/mnt. Durante operasi dilakukan monitoring pada tekanan darah, saturasi 02 nadi dan EKG dengan monitor elektrik. Anestesi dilakukan selama 100 menit, operasi berlangsung selama 60 menit. Durante operasi tidak didapatkan penyulit anestesi maupun pembedahan. Pasca operasi pasien tetap terintubasi dengan sedasi, nafas spontan assist. Perawatan pasca operasi dilakukan di ICU.
Pengaruh Rifampisin terhadap Lama Hidup Mencit Sundari, Sri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2004)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Malaria is one among the most important public health problems in tropi¬cal countries like Indonesia. Several actions have been taken to overcome this problem, however its prevalence is still high. Parasite resistance to chlo- roquine and vector resistance to insecticide are the major constraint in deal¬ing with malaria. To provide an alternative treatment which are highly effications, safe, and widely available i.e antibiotics is one among the alternatives and has been used since a long time . One of the antibiotic used is rifampicyn. This study is assessing the effect of rifampicyn to the longevity of Swiss mice infected by Plasmodium berghei. The subjects are fifteen female mice inoculated with Plasmodium berghei. All of them divided into three groups, positive controle, negative controle and experiment group . The experiment groups were randomly allocated into 3 groups of 5 mice wich were treated with rifampicyn 100 mg/kg BW, rifampicyn 200 mg/kg BW and rifampicyn 300 mg/kg BW. Another 2 control groups were given 0,5 ml aquadest per mice, and chloroquine 25 mg/kg BW. All of drugs given twice daily for 5 days. The degree of parasitemia were examined daily using thin blood smears up to death from the inoculation and were analyzed by log-probit method. The longevity of mice was analyzed using anava method. The study showed that rifampicyn 300 mg/kg BW cured Plasmodium berghei infection in Swiss mice (p<0,01) and rifampicyn 200 mg/kg BW gave for longer life (p<0,05). Effective dosage 50 of rifampicyne is 13,533 mg/kg BW.Malaria merupakan salah satu yang menjadi masalah kesehatan masyarakat di icgara berkembang seperti Indonesia. Beberapa tindakan telah dilakukan untuk mengatasi masalah ini, tetapi prevalesinya masih tetap tinggi. Resistensi parasit Terhadap klorokuin dan resistensi vektor terhadap insektisida merupakan faktor penyebabnya. Salah satu pilihan pengobatan dalam mengatasi resistensi yang memiliki efikasi tinggi, aman dan sudah digunakan secara luas adalah menggunakan iztibiotika. Salah satu antibiotika yang dapat digunakan adalah Rifampisin. Penelitian ini bertujuan untuk mengetahui efek rifampisin terhadap lama hidup mencit Swiss yang diinfeksi Plasmodium berghei. Subyek penelitian terdiri dari 15 ekor mencit Swiss betina yang diinokulasi dengan Plasmodium berghei. Subyek penelitian dibagi menjadi 3 kelompok yaitu kontrol positif, kontrol negatif dan kelompok percobaan. Kelompok percobaan dibagi menjadi 3 kelompok yang masing- masing kelompok terdiri dari 5 ekor yang diberikan pengobatan Rifampisin 100 mg/ kg BB, 200 mg/kg BB, dan 300 mg/kg BB. Dua kelompok yang lain masing-masing diberikan 0,5 ml akuades dan klorokuin 25 mg/kg BB. Pengobatan diberikan 2x/hari selama 5 hari. Pemeriksaan angka parasitemia dilakukan setiap hari dengan pemeriksaan apusan darah tipis. Lama hidup mencit dianalisis dengan Anava dan ED50 menggunakan analisis probit. Hasil penelitian menunjukkan bahwa rifampisin 300 mg/kg Bb dapat menyembuhkan mencit Swiss dari infeksi (p<0,01), rifampisin 200 mg/kg Bb memperlama hidup mencit (p<0,05). EDS0 rifampisin adalah 13,533 mg/kg BB.

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