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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 13 Documents
 1   2 
Search results for , issue "Vol 2, No 2 (2002)" : 13 Documents clear
The No. 3 Craniofacial Cleft - Sagiran
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 2, No 2 (2002)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v2i2.1512

Abstract

Sumbing no.3 merupakan satu di antara 14 tipe kelainan sumbing kraniofasial kongenital. Lokasi sumbing ini bertepatan dengan tempat pertemuan antara proces¬sus maxillaris dan frontonasalis pada masa perkembangan embryonal. Mengetahui embryologi leher dan kepala memberi pemahaman mengenai fungsi saraf kepala, prinsip-prinsip pembentukan kepala-wajah dan kelainan-kelainannya yang merupakan akibat penyimpangan dari perkembangannya. Penanganan kelainan ini memerlukan bedah rekonstruksi yang canggih. Makalah ini melaporkan kasus seorang anak perempuan 1,5 tahun dengan sumbing kraniofasial no 3.The No. 3 Cleft is one of 14 types of congenital craniofacial cleft anoma¬lies. The location of no. 3 cleft coincides with the embryonic junction of the maxillary and frontonasal processes. There is no theory of the causes but some hypothetic risk factors have been proposed. Understanding of head and neck embryology gives rationale to the function of the cranial nerves, prin¬ciples of craniofacial form, and anomalies that result from aberrations in their development. Treatment of this malformation needs excellent reconstructive surgery. This paper is reporting a case of the no. 3 craniofacial cleft in a 1.5- year-old female.
Efek Samping Kemoterapi dan Radioterapi pada Sel-sel Spermatogenik dan Spermatozoa Alfaina Wahyuni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 2, No 2 (2002)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v2i2.1507

Abstract

Medical treatment for cancer is a combination of operative treatment, ra-diotherapy and chemotherapy. Theoretically, anticancer agent can kill can¬cer cells. However, it also causes many side effects especially on the normal cells, which have high mitosis activity. One of them is spermatogenic cell. Anticancer agent is included into reproductive toxin. Its working mecha-nism is by the alkylation of biologic molecules. Radiotherapy and chemotherapy reduce the number of spermatogonia Al, spermatogonia B and cause aberation of DNA structures on the next-generation cells including spermatozoa, hence result in the decrease of number of spermatozoa and sperm motility and the increase of the percentage of spermatozoa with abnormal morphology. The effects of radiotherapy and chemotherapy are temporary and reversibel. The cell recovery depends on the type of anticancer agent, its dosage and the length of therapy applied. Spermatogonia stem cells are the most important factors on this process.Tindakan medis yang dilakukan untuk pengobatan kanker adalah kombinasi pembedahan, radioterapi dan kemoterapi. Secara teoritis bahan antikanker bisa membunuh sel kanker, tetapi kenyataannya banyak menimbulkan efek samping terutama pada sel normal yang mempunyai aktivitas pembelahan cepat. Salah satu diantaranya adalah sel-sel spermatogenik. Bahan-bahan antikanker termasuk dalam golongan toksin reproduktif. Mekanisne kerjanya dengan cara mengalkilasi molekul biologis. Pascaradioterapi dan kemoterapi terjadi penurunan jumlah spermatogonia Al dan B dan menyebabkan aberasi struktur DNA pada generasi sel berikutnya termasuk spermatozoa. Akibatnya jumlah dan motilitas menurun dan persentase abnormalitas spermatozoa meningkat. Efek radioterapi dan kemoterapi bersifat temporer dan bisa terjadi pemulihan. Pemulihan sangat tergantung pada jenis bahan antikanker, dosis dan lama pemberian. Sel spermatogonia induk merupakan faktor terpenting dalam proses tersebut.
Kajian terhadap Pemeriksaan Haemoglobin (Hb) Ratna Indriawati
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 2, No 2 (2002)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v2i2.1510

Abstract

The prevalence of anemia among pregnant women and under-five-year- old children in Indonesia is still very high. Hemoglobin (Hb) estimation assists in detecting anemia. There are two methods on measuring Hb by colorimetries i.e. Sahli and Talquist. The objective of this study was to compare the value of Sahli and Talquist methods by using the agreement test. This study was conducted in Physiology Laboratory, Faculty of Medicine, Muhammadiyah University of Yogyakarta. A total number of 39 students who took Physiology were enrolled to this study. The Hb level measurement was conducted by trained students. Two students conducted the Hb level measure-ment using Sahli and Talquist methods randomly. Subjects of the study were 39 students consisted of 18 men and 21 women. The age mean was 20 ± 2,2. Using Talquist method, the Hb levels among men were significantly higher than women (p-0.02). Kappa coeffisient was calcu-lated to know the agreement between Sahli and Talquist methods. The Hb levels were catagorized into two groups using cut-off point 12 mg/dl, 10 mg/dl and 8 mg/dl, respectively. The agreement based on those three cut-off point was low, kappa coefficient were 0.24, 0.20 and 0.22, respectively. There were differences on the Hb level measurement between Sahli and Talquist methods (the agreement test with K=0,24; K=0,22 and K=0,20 were low).Prevalensi anemia pada wanita hamil dan anak-anak di bawah lima tahun di Indonesia masih sangat tinggi. Untuk menentukan adanya anemia perlu pemeriksaan kadar hemoglobin (Hb). Pemeriksaan kadar Hb secara kolorimetris ada 2 cara yaitu, metode Sahli dan Talquist Tujuan dari penelitian ini adalah membandingkan hasil pengukuran kadar Hb menggunakan metode Sahli dan Talquist dengan uji kesepakatan. Penelitian ini dilakukan di Laboratorium Fisiologi, Fakultas Kedokteran Univer-sitas Muhammadiyah Yogyakarta. Jumlah subyek 39 orang mahasiswa yang mengambil matakuliah fisiologi. Mahasiswa sebelumnya dilatih dahulu. Dua orang mahasiswa melakukan pemeriksaan Hb dengan metode Sahli dan Talquist, secara acak. Subyek penelitian ini adalah 39 mahasiswa, terdiri dari 18 laki-laki dan 21 perempuan, yang berusia rata-rata 20 +2,2 tahun. Pemeriksaan kadar Hb metode Talquist didapatkan perbedaan bermakna antara kadar Hb laki-laki dan perempuan (p=0,02). Perhitungan dengan koefisien Kappa untuk mengetahui kesepakatan antara metode Sahli dengan Talquist. Kadar Hb dikategorikan diam 2 kelompok menggunakan cut-off point 12 g/dl, 10 g/dl dan 8 g/dl. Uji kesepakatan pada 3 cut¬off point tersebut rendah, koefisien Kappa 0,24,0,20 dan 0,22. Terdapat perbedaan hasil pemeriksaan kadar Hb metode Sahli dan Talquist (uji kesepakatan dengan K=0,24, K=0,22 dan K=0,20 rendah).

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