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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 12 Documents
 1   2 
Search results for , issue "Vol 14, No 1 (2017)" : 12 Documents clear
Evaluation of the Use of Antibiotics in Chronic Renal Failure Patients in RSUP Dr. Soeradji Tirtonegoro Klaten Period 2014 Pradina, Gita Ayu; Cholisoh, Zakky
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.542

Abstract

Antibiotics are one of the most widely used drugs in curing various kinds of infectious diseases. The use ofantibiotics, especially in chronic renal failure, need to be considered because it can cause nephrotoxicityin kidneys. The purpose of this study was to evaluate the rational use of antibiotics in RSUP Dr. SoeradjiTirtonegoro in cases of chronic renal failure in 2014. The evaluation includes the right indication, theright drug, right patient, and proper dosage. This research is conducted in a manner that is based on aretrospective medical record belongs to chronic renal failure patients on inpatient RSUP Dr. TirtonegoroKlaten 2014. The search results obtained from medical records and evaluation results indicated the useof appropriate antibiotics as many as 20 cases (55.56%), patients with chronic renal failure who meet theappropriate criteria are 39 cases (97.7%), use of the right type of antibiotics drugs there were 13 cases(29,5%), and to use appropriate antibiotics doses were 21 cases (47.7%). Discharge status of patientswith a total of 36 cases (100%) with result of the patient’s health improved. From the result of arithmeticleukocytes figure, there are 33 cases ( 91.67 % ) with leukocytes count back to normal.
The Evaluation of Antibiotics Using to Pediatric Acute Upper Respiratory Tract Infection Patients at Health Centers in Kunduran Blora 2013 Antoro, Tesar Zulmi; Mutmainah, Nurul
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.551

Abstract

Acute respiratory tract infection is an acute infection which attacks one or more part of respiratory tractfrom nose to alveoli. This disease is an important society’s health problem especially in the developingcountries which attacks children easily especially who have low body’s immunity. This aim of the researchwas to know representation of the treatment and the accuracy of antibiotics distribution as the treatment ofpediatric patients of acute upper respiratory tract infection (AURTI) at Health Center in Kunduran, Blora2013 which is observed by appropriate parameter indication, appropriate drugs, appropriate dose andappropriate patients using the standard from WHO (2003). This research was categorized as qualitativeand non experimental research. In obtaining the data, the researcher trace the pediatric patient’s medicalrecord in the registration book in the health center Kunduran, Blora regency year 2013. The obtained datawas analyzed descriptively to evaluate the rationality of antibiotics distribution for AURTI. The researchresult showed that over 110 of the available samples in children aged up to 12 years old which werediagnosed as AURTI sufferer, 92 cases (83.63%) used amoxicillin antibiotics, 18 cases (16.37%) usedkotrimoksazol, 72 cases (65.50%) were proper indication, 59 case (53.63%) were proper drugs, 110 cases(100%) were proper patients, 87 case (79.09%) were proper dose, and 47 case (42.70) were rational in thetreatment
Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain Tary, Neni Lugki Nian; Sujono, Tanti Azizah
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.540

Abstract

The used of plants efficacious as medicines in the prevention of health problems had been known for along time the Indonesian people. The utilization of plants as medicine was based on the experience passeddown from generation to generation. The used of traditional medicines relatively favored by the people,the underlying factor are traditional medicines have less side effects than the modern medicines if usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment which had stimulant effect..Stimulant was a substance that can stimulated the central nervous system which can speed up the processesin the body and minimize fatigue. Need to research the effects of stimulant infusion of curcuma rhizome.The research was conducted experimental methods pre-test and post-test. Twenty-five male mice Swissstrain used as experimental animals, which are divided into five groups, positive control (caffeine 100mg /kg BW), negative control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal experiments tested using methods NatatoryExhaustion and treated with oral route. The effects of stimulant tired was calculated the time differencebefore and after treatment. The data obtained were analyzed non-parametric statistical tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse curcuma rhizome had the stimulant effect,the effect was obtained by increased the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes. Stimulant effect doseII and III had a greater effect than the positive control (p<0,05), the dose I had similar effect compare withcontrol positive (p>0,05). 
Optimum Conditions for Extraction of Antibacterial Compounds from Citrus Aurantifolia Fruit Peel Waste Munawaroh, Rima
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.5779

Abstract

Citrus fruit peel is a major waste in citrus fruit processing industry. The research on extraction activecompounds of Citrus aurantifolia (lime) fruit peel waste and antibacterial activity assay has been done. Theaim of research was to get optimum condition to extract their active compounds which have antibacterialactivity. The dried lime fruit peel was extracted by maceration method using ethanol 48%, 72%, and 96%.The dried and fresh lime fruit peel were also extracted using ethyl acetate. Antibacterial assay was done bydiffusion agar against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The resultshowed that optimal condition to extract antibacterial compound using fresh sample with ethyl acetate assolvent. The ethyl acetate extract of fresh sample was more active against S. aureus than E. coli.
ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT AND INFUSE OF Bauhinia variegata LEAVES AGAINST Streptococcus pyogenes sholihah, istiqamatush
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.424

Abstract

Bauhinia variegata is a plant that has many virtues and widely grown in Indonesia. Yet the virtues and uses are still limited as the shade and ornamental plant. The purpose of this study is to determine the antibacterial ethanol extract activity and the infuse of Bauhinia Variegata leaves toward Streptococcus pyogenes and to determine the classes of compounds that have antibacterial activity. Bauhinia variegata leaves are extracted by maceration and infundation with 96% ethanol and distilled water. The test method of antibacterial activity is used disc difusson Kirby Bauer methods. The Analyses of the compounds which are contained in the Bauhinia Variegata leaves are done by TLC (Thin Layer Chromatography) and test tubes. The results showed that ethanol extract and infuse of Bauhinia Variegata leaves has no antibacterial activity toward Streptococcus pyogenes. TLC results and test tubes showed that the ethanol extract of Bauhinia Variegata leaves contain tannins, saponins, terpenoids, and alkaloids. While, the infuse of Bauhinia variegata leaves are saponins and alkaloids. Keywords: Bauhinia variegata, antibacterial, Streptococcus pyogenes, maceration, infundation.
EFFECT OF BLACK RICE BRAN EXTRACT (Black Rice Bran) TO DECREASE DECREASE OF GLUCOSE LEVEL IN DIABETIC RATS Sari, Novita; Wahyuni, Arifah Sri
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.539

Abstract

Black rice bran is one of processed foods derived from plants and has a decreasing effect of blood glucoselevels. Major component of anthocyanin in black rice bran that functions in lowering blood glucoseconcentration is cyanidin 3-glucoside. Fifteen male rats Sprague-Dawley strain were selected randomly anddivided into 5 groups with the same number in each groups. These groups were consisted of normal control,negative control, and black rice bran extract treatment with dose of 50, 100 and 200 mg/kg of bodyweight(b.w.). Each of them were induced to experience diabetes by alloxan 150 mg/kg of b.w. Measurement ofblood glucose levels was done by using visible spectrophotometer at 546 nm. The samples were collectedbefore and after alloxan injection, and after 4, 7, and 10 days later to observe the changes of blood glucoselevels. The results showed that black rice bran at 200 mg/kg of b.w. was able to lower the glucose levels,which amounted for 131,33 ± 8,08 mg/dL after 10 days of injection.
EFFECT OF BLACK RICE BRAN EXTRACT (Black Rice Bran) TO DECREASE DECREASE OF GLUCOSE LEVEL IN DIABETIC RATS Novita Sari; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.539

Abstract

Black rice bran is one of processed foods derived from plants and has a decreasing effect of blood glucoselevels. Major component of anthocyanin in black rice bran that functions in lowering blood glucoseconcentration is cyanidin 3-glucoside. Fifteen male rats Sprague-Dawley strain were selected randomly anddivided into 5 groups with the same number in each groups. These groups were consisted of normal control,negative control, and black rice bran extract treatment with dose of 50, 100 and 200 mg/kg of bodyweight(b.w.). Each of them were induced to experience diabetes by alloxan 150 mg/kg of b.w. Measurement ofblood glucose levels was done by using visible spectrophotometer at 546 nm. The samples were collectedbefore and after alloxan injection, and after 4, 7, and 10 days later to observe the changes of blood glucoselevels. The results showed that black rice bran at 200 mg/kg of b.w. was able to lower the glucose levels,which amounted for 131,33 ± 8,08 mg/dL after 10 days of injection.
Evaluation of the Use of Antibiotics in Chronic Renal Failure Patients in RSUP Dr. Soeradji Tirtonegoro Klaten Period 2014 Gita Ayu Pradina; Zakky Cholisoh
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.542

Abstract

Antibiotics are one of the most widely used drugs in curing various kinds of infectious diseases. The use ofantibiotics, especially in chronic renal failure, need to be considered because it can cause nephrotoxicityin kidneys. The purpose of this study was to evaluate the rational use of antibiotics in RSUP Dr. SoeradjiTirtonegoro in cases of chronic renal failure in 2014. The evaluation includes the right indication, theright drug, right patient, and proper dosage. This research is conducted in a manner that is based on aretrospective medical record belongs to chronic renal failure patients on inpatient RSUP Dr. TirtonegoroKlaten 2014. The search results obtained from medical records and evaluation results indicated the useof appropriate antibiotics as many as 20 cases (55.56%), patients with chronic renal failure who meet theappropriate criteria are 39 cases (97.7%), use of the right type of antibiotics drugs there were 13 cases(29,5%), and to use appropriate antibiotics doses were 21 cases (47.7%). Discharge status of patientswith a total of 36 cases (100%) with result of the patient’s health improved. From the result of arithmeticleukocytes figure, there are 33 cases ( 91.67 % ) with leukocytes count back to normal.
The Evaluation of Antibiotics Using to Pediatric Acute Upper Respiratory Tract Infection Patients at Health Centers in Kunduran Blora 2013 Tesar Zulmi Antoro; Nurul Mutmainah
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.551

Abstract

Acute respiratory tract infection is an acute infection which attacks one or more part of respiratory tractfrom nose to alveoli. This disease is an important society’s health problem especially in the developingcountries which attacks children easily especially who have low body’s immunity. This aim of the researchwas to know representation of the treatment and the accuracy of antibiotics distribution as the treatment ofpediatric patients of acute upper respiratory tract infection (AURTI) at Health Center in Kunduran, Blora2013 which is observed by appropriate parameter indication, appropriate drugs, appropriate dose andappropriate patients using the standard from WHO (2003). This research was categorized as qualitativeand non experimental research. In obtaining the data, the researcher trace the pediatric patient’s medicalrecord in the registration book in the health center Kunduran, Blora regency year 2013. The obtained datawas analyzed descriptively to evaluate the rationality of antibiotics distribution for AURTI. The researchresult showed that over 110 of the available samples in children aged up to 12 years old which werediagnosed as AURTI sufferer, 92 cases (83.63%) used amoxicillin antibiotics, 18 cases (16.37%) usedkotrimoksazol, 72 cases (65.50%) were proper indication, 59 case (53.63%) were proper drugs, 110 cases(100%) were proper patients, 87 case (79.09%) were proper dose, and 47 case (42.70) were rational in thetreatment
Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain Neni Lugki Nian Tary; Tanti Azizah Sujono
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.540

Abstract

The used of plants efficacious as medicines in the prevention of health problems had been known for along time the Indonesian people. The utilization of plants as medicine was based on the experience passeddown from generation to generation. The used of traditional medicines relatively favored by the people,the underlying factor are traditional medicines have less side effects than the modern medicines if usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment which had stimulant effect..Stimulant was a substance that can stimulated the central nervous system which can speed up the processesin the body and minimize fatigue. Need to research the effects of stimulant infusion of curcuma rhizome.The research was conducted experimental methods pre-test and post-test. Twenty-five male mice Swissstrain used as experimental animals, which are divided into five groups, positive control (caffeine 100mg /kg BW), negative control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal experiments tested using methods NatatoryExhaustion and treated with oral route. The effects of stimulant tired was calculated the time differencebefore and after treatment. The data obtained were analyzed non-parametric statistical tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse curcuma rhizome had the stimulant effect,the effect was obtained by increased the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes. Stimulant effect doseII and III had a greater effect than the positive control (p0,05), the dose I had similar effect compare withcontrol positive (p0,05). 

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