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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
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Articles 6 Documents
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Search results for , issue " Vol 11, No 2 (2017): April - June" : 6 Documents clear
Faktor yang Memengaruhi Episode Transfusi Packed Red Cell (PRC) pada Anak dengan Keganasan PURWANTO, DIAN A.P; MULATSIH, SRI; TRIYONO, TEGUH
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTPRC transfusion is an adjuvant therapy frequently used in children with malignancy. There are some factors affecting transfusion episodes. For rational use of PRC must consider these factors. Objective: To find factors affecting transfusion episodes in children with malignancy. This retrospective cohort study evaluated children with malignancy between January 1 and December 31, 2015 who were admitted to Sardjito hospital. Patients were receiving therapy dan PRC transfusion during the four months following cancer diagnosis. Those with incomplete data or renal failure were excluded. The influence of these factors were analyzed with Chi-square or Fisher’s exact and Kolmogorov-Smirnov when iligible, and the most influential factor were analyzed by logistic regression. Out of 123 subjects receiving a PRC transfusion, 56 (45,5%) subjects received a PRC transfusion more than one times episodes. Higher episodes of transfusion were observed for patients whose bleeding (RR 6.940 (95%CI 2.563 to 18.790). Lower episodes of transfusion were observed for patients receiving transfusion previously and hematological malignancies, but the result were not significant (RR 0,524 (IK95% 0,057 – 4,852) and 0,464 (IK 95% 0,140 – 1,540) respectively). Bleeding is factor affecting transfusion episodes of PRC in children with malignancy.ABSTRAKTransfusi PRC merupakan terapi adjuvant yang sering digunakan pada anak dengan keganasan. Terdapat beberapa faktor yang memengaruhi episode transfusi sehingga penggunaan PRC rasional harus mempertimbangkan faktor tersebut. Penelitian ini bertujuan mengetahui faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. Penelitian kohort retrospektif pada anak (0 –18 tahun) yang dirawat di RSUP Dr. Sardjito dengan penyakit keganasan yang telah terdiagnosis selama empat bulan dan mendapat terapi serta transfusi PRC sejak 1 Januari – 31 Desember 2015. Register tidak lengkap atau dengan gagal ginjal dieksklusi. Pengaruh faktor– faktor tersebut dianalisis dengan uji Chi-square atau uji Fisher serta Kolmogorov-Smirnov bila tidak memenuhi syarat, dan faktor yang paling berpengaruh dianalisis dengan uji logistic regression. Dari 123 subjek, 56 subjek dengan episode transfusi PRC > 1 kali. Keganasan hematologi, riwayat transfusi, dan perdarahan memengaruhi episode transfusi PRC > 1 kali. Analisis multivariat didapatkan perdarahan memengaruhi episode transfusi PRC > 1 kali (RR 6,940 (IK95% 2,563 – 18,790), namun riwayat transfusi dan keganasan hematologi tidak bermakna dengan nilai RR secara berturut-turut 0,524 (IK95% 0,057 – 4,852) dan 0,464 (IK 95% 0,140 – 1,540). Penelitian ini menyimpulkan bahwa perdarahan merupakan faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. 
Faktor Klinis dan Histopatologi serta Hubungannya dengan Kekambuhan Pascaoperasi pada Pasien Kanker Payudara di RSUD Dr. Soetomo, Januari–Juni 2015 EVELINE, KEZIA; PURWANTO, HERU; LESTARI, PUDJI
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACT Breast cancer recurrence occurs because of factors such as surgical problem and clinicopathological features. The present study aimed to assess the relation between clinicopathological factors to breast cancer recurrence. Cross sectional design was used to take medical documents of all patients who visited Out Patient Department Soetomo Hospital from January 2015 to June 2015. A total of 228 patients were identified. The rates of breast cancer recurrence were 30%, most of recurrence occurred in first 5 years and the peak was in the first year. There were significant correlations between breast cancer recurrence and the factors observed below: tumor size [p=0.01,PR(95% CI)=1.621(1.086-2.421)]; nodal status 1-3 and ≥ 4 ≥ 4 [respectively p=0.014,PR(95%CI)=1.281(1.030-2.593) ; p=0.011,PR(95%CI) =1.289(1.038-1.601)]; tumor location [p=0.00,PR(95%CI)=2.422(1.576-3.721)]; hospital where the operation performed [p=0.03,PR(95%CI)=1.207(1.026-1.421)]; adjuvant therapy [p=0.00,PR(95%CI)= 4.371(2.231- 8.566)]. However there were no correlations of breast cancer recurrence and age, clinical stage or type of surgery. Conclusion, there are significant correlations between breast cancer recurrence and clinicopathological factors, such as tumor size, nodal status, tumor location, hospital where the operation performed and adjuvant therapy ABSTRAKKekambuhan kanker payudara terjadi karena beberapa faktor, di antaranya faktor klinis dan histopatologis. Penelitian ini bertujuan untuk mengetahui hubungan faktor klinis dan histopatologi terhadap kekambuhan. Penelitian ini menggunakan desain cross sectional dengan mengambil data dari rekam medis pasien yang berkunjung ke Unit Rawat Jalan RSUD Dr. Soetomo periode Januari- Agustus 2015. Sebanyak 228 pasien diidentifikasi. Tingkat kekambuhan kanker payudarasebsar 30%, sebagian besar kekambuhan terjadi dalam 5 tahun pertama, dan puncaknya adalah pada tahun pertama. Ada hubungan yang signifikan antara kekambuhan kanker payudara dengan faktor-faktor yang diamati: ukuran tumor [p=0,01, PR (95%CI) =1,621 (1.086-2.421)]; status nodal 1-3 and ≥ 4 ≥ 4 [masing-masing p=0,014,,PR(95%CI) = 1.281(1.030-2.593); p=0,011, PR (95%CI) = 1.289(1.038-1.601)]; letak tumor [p=0,00, PR(95%CI) = 2.422(1.576-3.721)]; rumah sakit tempat operasi dilaksanakan[p=0,03, PR,(95%CI)=1.207(1.026-1.421)]; terapi adjuvant [p=0,00, PR(95%CI)= 4.371(2.231-8.566)]. Namun, tidak ada korelasi antara kekambuhan kanker payudara dengan usia, stadium klinis, dan jenis operasi. Kesimpulan, terdapat hubungan yang signifikan antara kekambuhan kanker payudara dengan ukuran tumor, status nodal, lokasi tumor, rumah sakit di mana operasi dilaksanakan, dan terapi adjuvant.
Uji Diagnosis Ultrasonografi Strain Ratio Elastography Dihubungkan dengan Histopatologi pada Palpable Mass Payudara di RSUP Dr. Hasan Sadikin, Bandung SOEKERSI, HARI; MAHADIAN, FERDI
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACT Strain ratio elastography ultrasound of palpable mass of the breast is one of ultrasound examination based on semiquantitative analysis, is currently widely used to assess tissue stiffness that vary. Strain ratio elastography ultrasound is expected to be able to establish a quick and proper diagnosis to get the right therapy resulting in lower morbidity and mortality in breast carcinoma. Strain ratio elastography ultrasound have been more useful on the morphology of lesions such as suspicious atypical benign (BIRADS 3), suspected malignant (BIRADS 4), suggestive of malignancy (BIRADS 5). The aim of this study to determine the results of the diagnostic tests strain ratio elastography ultrasound associated with histopathology in palpable breast mass in Dr. Hasan Sadikin General Hospital. This research is an analytic observational study and a diagnostic test of strain ratioelastographyultrasound associated with histopathology in palpable breast mass with a model to assess the validity of cross sectional. Sampling was conducted prospectively and performed in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung from November 2016 to January 2017. Data analysis using univariate analysis and bivariate analysis and Chi Square test. Results, the subject of study are 32 female patients, the youngest are 21 years old and the oldest are 72 years old. The results of diagnostic tests strain ratio elastography ultrasound in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung with a sensitivity 81.5%, specificity 80.0%, accuracy of 81.3%, PPV 95.7% and NPV 44.4%. Conclusion: strain ratio elastography ultrasound has value of sensitivity and specificity that is high enough in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung.ABSTRAK Ultrasonografi (USG) strain ratio elastography pada palpable mass payudara yang merupakan salah satu turunan dari pemeriksaan USG berdasarkan analisis semikuantitatif, saat ini banyak digunakan untuk menilai kekakuan jaringan yang bervariasi. Dengan USG strain ratio elastography diharapkan dapat mendiagnosis dengan tepat dan cepat untuk mendapatkan terapi yang tepat sehingga menurunkan angka morbiditas serta mortalitas pada karsinoma payudara. USG strain ratio elastography lebih bermanfaat pada morfologi lesi-lesi atipikal seperti curiga jinak (BIRADS 3), curiga ganas (BIRADS 4), atau sugestif keganasan (BIRADS 5). Histopatologi merupakan baku emas untuk mendiagnosis palpable mass dan non palpable mass payudara. Penelitian ini bertujuan mengetahui hasil uji diagnosis USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara di RSUP Dr. Hasan Sadikin, Bandung. Penelitian ini merupakan studi observasional analitik dan merupakan suatu uji diagnosis dari USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara dengan model cross sectional untuk menilai validitas. Pengambilan sampel dilakukan secara prospektif dan dilakukan di Departemen Radiologi/ RSUP Dr. Hasan Sadikin, Bandung, dari November 2016 sampai Januari 2017. Data dianalisis menggunakan analisis univariabel dan bivariabel menggunakan uji Chi square. Hasil penelitian menunjukkan subjek penelitian sebanyak 32 penderita wanita, usia termuda 21 tahun, dan usia tertua 72 tahun. Hasil uji diagnosis USG strain ratio elastography dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung, menunjukkan sensitivitas 81,5%; spesifisitas 80,0%; akurasi 81,3%; PPV 95,7%; dan NPV 44,4%. Penelitian ini menyimpulkan bahwa USG strain ratio elastography memiliki nilai sensitivitas dan spesifisitas yang cukup tinggi dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung.
Simple Bone Cyst Management: Percutaneous Steroid Injection Versus Curettage With Hydroxiapatite KAMAL, ACHMAD FAUZI; APRIZAL, RIZA; PRABOWO, YOGI
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACT The main goals of the therapy of simple bone cyst (SBC) are to get the bone healing, prevent pathological fractures, and management of pain symptom. There are various methods of the SBC treatments, however they still remain controversial because of their healing rate and invasiveness of surgery. A total of 10 SBC patients were divided into two groups namely curretage with hydroxyapatite (HA) and decompression and percutaneous steroid injection (PSI). PSI was performed three times at intervals of each month. The mean followup of 12-26 months. Evaluation of functional outcome by Musculoskeletal Tumour Society (MSTS) score and supported with radiologically based on Chang criteria. There were 5 patients (proximal femur 2; proximal humerus 2, radius 1) performed curretage with HA therapy. Remaining 5 patients (proximal femur 3; proximal humerus 1; calcaneus 1) were performed PSI therapy. PSI group had better MSTS score, particulary at month 3 (55%) and month 6 (84%) than curettage with HA therapy (47% and 69.3%). Complete bone healing was found in both group at month 12 follow up, however solid union occurred faster in PSI group. PSI tends to have faster and better functional outcome than curettage and HA. Curettage with HA and PSI have similar complete bone healing at month 12 follow up. ABSTRAKTarget utama penalaksanaan simple bone cyst (SBC) adalah mencapat penyembuhan tulang yang sempurna, mencegah fraktur patologis dan mengatasi gejala nyeri. Ada beberapa metode penatalaksanaan SBC, namun demikian masih menjadi perdebatan dikarenakan perbedaan angka penyembuhannya dan jenis pembedahan yang invsif. Sepuluh pasien yang didiagnosis SBC dikelompokkan menjadi kelompok yang mendapat tindakan curretage dan pengisian defek dengan hydroxyapatite (HA) dan kelompok dekompresi dan percutaneous steroid injection (PSI). Prosedur PSIdilakukan sebanyak 3x dengan interval waktu satu bulan. Follow up dilakukan selama 12 – 26 bulan. Evaluasi luaran fungsional menggunakan Musculoskeletal Tumour Society (MSTS) score dan secara radiologi sesuai criteria Chang. Terdapat 5 pasien (2 femur proksimal, 2 humerus proksimal, dan 1 radius) yang dilakukan prosedur curretage dan pengisian defek dengan HA. Lima pasien sisanya ( 3 fenur proximal, 1 humerus proximal dan 1 calcaneus) dilakukan prosedur PSI. Luaran fungsional Kelompok PSI memiliki MSTS score yang lebih baik, khususnya pada bulan ke- 3 (55%) dan bulan ke-6 (84%) daripada kelompok curettage dengan HA (47% dan 69.3%). Penyembulan tulang sempurna menunjukkan hasil yang sama pada evaluasi bulan ke-12, tetapi solid union didapatkan lebih cepat pada kelompok PSI. Kelompok PSI memiliki kecenderungan solid union dan luaran fungsional yang lebih cepat daripada kelompok curettage dengan HA. Kedua kelompok mencapai penyembuhan sempurna pada bulan ke-12 follow up
Penerapan Solution-Focused Brief Therapy dalam Meningkatkan Self-Esteem pada Remaja Perempuan Penderita Leukemia SOETIKNO, NAOMI; TEHUTERU, EDI SETIAWAN; MIRANDA, JESSICA; PATMONODEWO, SOEMIARTI
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACT The diagnosis of cancer have an impact on physical and psychological development of adolescent. Psychological impact is felt with the emergence of some emotional reactions, such as fear, anxiety, sadness, despair, anger, guilt, and shame. Adolescents who experience physical and psychological impact of the treatment of the cancer will experience problems in self-esteem and body image, that have an impact on the development of adolescent self until early adulthood. The establishment of self-esteem need to occur in adolescence. In adolescence, the individual will develop a positive sense of self so that adolescence is an important period for individuals to establish self-esteem, because at this time many changes occur both physically and emotionally. This study was conducted to help improve self-esteem in young woman with leukimia with solution-focused brief therapy. The participant of this study was two participants adolescent female with early-stage leukimia ALL types for two years. This therapy was conducted in three weeks by researcher herself. Researcher used questionnaries measuring selfesteem and graphics tests before and after the intervention to measure the role of therapy programs. Solution-focused brief therapy used in this study shows no role to improve the self-esteem of adolescent female patients with leukimia. This is because the PA subjects only increased by 2 points and subjects SS increased scores by 10 points ABSTRAK Diagnosis kanker memiliki dampak fisik dan psikologis bagi perkembangan remaja. Dampak psikologis yang dirasakan berupa timbulnya beberapa reaksi emosional, seperti takut, cemas, sedih, putus asa, marah, merasa bersalah, dan malu. Remaja yang mengalami dampak fisik dan psikologis dari pengobatan kanker yang dideritanya akan mengalami permasalahan pada self-esteem dan body image yang berdampak pada pengembangan diri remaja tersebut hingga masa dewasa awal. Pembentukan self-esteem terjadi pada masa remaja. Pada masa remaja individu akan mengembangkan sense of self yang positif sehingga masa remaja merupakan masa yang penting bagi individu untuk membentuk self-esteem, karena pada masa ini banyak terjadi perubahan-perubahan, baik secara fisik maupun emosi. Penelitian ini dilakukan untuk membantu meningkatkan self-esteem pada remaja perempuan penderita leukemia dengan solution-focused brief therapy. Penelitian ini dilakukan terhadap dua partisipan remaja perempuan penderita leukemia jenis ALL stadium awal selama dua tahun. Proses pemberian terapi dilakukan selama 3 minggu. Peneliti menggunakan alat ukur “Kuesioner Harga Diri” serta tes grafis sebelum dan sesudah intervensi untuk mengukur peranan program terapi. Solution-focused brief therapy yang digunakan dalam penelitian ini menunjukkan bahwa terapi tersebut tidak berperan dalam meningkatkan self-esteem remaja perempuan penderita leukemia. Hal ini dikarenakan subjek PA hanya mengalami peningkatan skor sebesar 2 poin dan subjek SS mengalami peningkatan skor sebesar 10 poin
Febrile Neutropenia pada Pasien Pascakemoterapi BUDIANA, I NYOMAN GEDE; FEBIANI, MELINDA
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTFebrile neutropenia (FN) is one of the side effects caused by chemotherapy due to hematopoetic suppression that cause neutropenia and other triggerring factors such as infection. More specifically, FN is defined as the temperature above 38,3oC at once oral temperature measurements or 38,0oC temperature within a period of time more than one hour with neutrophil counts less than 500/mm3 or neutrophil counts less than 1000/mm3 with predicted decline to 500/ mm3 within 48 hours. Febrile neutropenia defined as a medical emergency and oncology which has a high mortality rate. Although currently there is a great development in the prevention and therapy of FN, but this is still the most feared complication of cancer chemotherapy. This article summarizes the important aspects of the FN as well as it’s early detection and management that should be of concern for clinicians who decide to use chemotherapy as one of treatment modality for their patients. ABSTRAKFebrile neutropenia (FN) merupakan salah satu efek samping dari kemoterapi yang disebabkan oleh supresi hematopoesis yang menyebabkan neutropenia ditambah dengan faktor pencetus lain seperti infeksi. Secara lebih spesifik, FN didefinisikan sebagai temperatur di atas 38,3oC pada sekali pengukuran suhu oral atau suhu 38,0oC dalam jangka waktu lebih dari 1 jam dengan hitung jenis neutrofil kurang dari 500/mm3 atau hitung jenis neutrofil kurang dari 1000/mm3 dengan prediksi terjadi penurunan sampai 500/mm3 dalam waktu 48 jam. Febrile neutropenia ditetapkan sebagai kegawatdaruratan medis dan onkologi yang memiliki angka mortalitas tinggi. Walaupun saat ini terdapat perkembangan besar pada prevensi dan terapi FN, FN masih merupakan komplikasi yang paling ditakuti. Artikel ini merangkum aspek-aspek penting dalam deteksi dan penatalaksanaan FN, di mana hal ini perlu menjadi perhatian klinisi yang memutuskan untuk menggunakan kemoterapi sebagai modalitas pengobatan pasien.

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