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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue " Vol 25 No 3, 2014" : 2 Documents clear
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL Koladi, Mohammad Ali
INDONESIAN JOURNAL OF PHARMACY Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.458 KB) | DOI: 10.14499/indonesianjpharm25iss3pp164

Abstract

Diabetes mellitus is associated with high morbidity and mortality among patients and its prevalence is increasing at an alarming rate worldwide. Insulin analogues are reported to have better efficacy and safety as compared to conventional insulin therapy, however, substantiation of data in different geographical areas with genomic variation is yet to be established. The study was aimed to evaluate and compare the effectiveness and clinical safety profile of insulin analogues with regular insulin. In this prospective, randomized, observational study conducted at a Superspeciality hospital in India,78 diabetic patients on insulin therapy were recruited. The efficacy and safety markers of 24 patients on biphasic insulin analogue, 33 on recombinant insulin analogue and 21 on regular insulin were observed for 13 weeks. The collected data was statistically analyzed by using Instat software.The efficacy markers such as glycosylated hemoglobin, fasting and postprandial glucose values showed superior improvement with the insulin analogues at the end of 13 weeks study. Insulin analogues produced significantly fewer incidents of minor hypoglycemia without any significant alteration in BMI and weight gain. The results of our studies suggest that insulin analogues are safer and effective with regards to glycemic control and in the event of hypoglycemia over regular insulin.
IMPROVEMENT OF DISSOLUTION RATE OF INDOMETHACIN FROM FAST DISSOLVING TABLETS Parhi, Rabinarayan
INDONESIAN JOURNAL OF PHARMACY Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (696.318 KB) | DOI: 10.14499/indonesianjpharm25iss3pp198

Abstract

In the current study Indomethacin (IM) fast dissolving tablets (FDTs) were prepared by direct compression technique in order to enhance its dissolution rate. The tablets were formulated using two different approaches; super-disintegration and efferves-cence. A combination formulation of above approaches was also developed to further improve its properties. The super-disintegrants used in the formulae were sodium starch glycolate (Primogel), cross-povidone (Kollidon) and cross-carmellose (Ac-di-sol). Sodium bicarbonate and citric acid combination was employed as effervescent ingredients. The prepared powder mixtures of IM were subjected to evaluation of various pre-compression parameters and tablets were evaluated for weight variation, dimension, hardness, friability, drug content, disintegration, wetting time, uniformity of dispersion, in vitro drug release and stability studies. The FT-IR spectra shown there are no interaction between of IM with excipient. The results of pre-compression studies indicate acceptable flow property for all the powder mixtures. The data of weight variation, dimension, hardness, friability, uniformity of dispersion and drug content studies were within the official limits. The wetting time and disintegration time decreases considerably with the increase in super-disintegrants amount. By using the combination approach, the disintegration and wetting time further decreased. In vitro dissolution studies were carried out using phosphate buffer pH 6.8 as dissolution medium for 60min and observed that formulation IF9, among super-disintegration approach, released highest percentage (97.13±2.09) of IM. In vitro drug release was highest (98.54±2.89) at 60 min for formulation IF11, when all the formulations were taken into consideration. The stability study was performed on the promised formulation IF11 at 40±2oC/ 75±5% RH for 3 months and the results indicated that there were no significant changes in aforesaid tablet properties.

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