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Journal Pharmaceutical Science and Application (JPSA)

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Published by Universitas Udayana

ISSN : 23017694 EISSN : 23017708 DOI : https://doi.org/10.24843/JPSA.2020.v02.i01

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 63 Documents

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Diffusion of Sodium Diclofenac from Carbopol 940 Gel at Various pH Ketut Widyani Astuti; Yeyet C. Sumirtapura; Ni Nyoman Wiwik S
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Diffusion of sodium diclofenac in Carbopol 940 gel has been investigated. Diffusion test was performed in diffusion cells with artificial membranes of Whatman no.1 filter paper which immersed with Spangler solution. Measurement of active ingredient concentration that diffuses was performed using UV spectrophotometer at a wavelength of 277 nm. The results showed that diffusion rate of sodium diclofenac from Carbopol gel increased at higher pH. The highest diffusion of diclofenac sodium occurs at pH 8 with a mean percentage of diclofenac sodium which diffuses after 240 minutes was 48.06 + 4.83%. The mean percentage of diclofenac sodium which diffuses from the gel Carbopol 940 at pH 6 after 240 minutes was 11.47 + 1.71% while the Carbopol 940 gel at pH 7 is 22.44 + 3.71%. Keywords: diffusion, diclofenac sodium, pH, gel Carbopol 940

THE EFFECT OF LAVENDER AROMATHERAPY ON DYSMENORRHOEA STUDENTS IN INSTITUTE OF HEALTH SCIENCE MEDICA PERSADA BALI AA Sg Dewi Pradnya Pramita; IA Manik Partha Sutema; Dhiancinantyan Windydaca Brata Putri
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Menstrual pain (dysmenorrhoea) is a symptom characterized by discomfort in the abdomen during menstruation. Lavender aromatherapy is beginning to be sought as one of the non-pharmacological therapies because the use of NSAIDs is reported to cause many side effects. The main components of lavender, linalool (35%) and linalyl acetate (51%) are efficacious as analgesics and maximally absorbed through the skin. Objective: This study aims to determine the effect of lavender aromatherapy on the menstrual pain of female college students at the Persada Medika Institute of Bali. Methods: Quasy experimental with one group pre-posttest design. The study was followed by 38 female students with moderate to severe pain using the random sampling technique. Data were analyzed using the non-parametric Wilcoxon test with p <0.05. Results: The results prior to lavender aromatherapy showed moderate pain at 73.7% and severe pain 26.3%. After lavender aromatherapy was administered, they showed moderate pain at 21% and mild pain at 79%. The Wilcoxon test indicated that the value of p = 0,000, where p <0.05. Conclusion: There is an effect of lavender aromatherapy to decrease menstrual pain (dysmenorrhoea) of female college students at the Persada Bali Institute of Health Sciences. Keywords: Aromatherapy Lavender, Dysmenorrhoea, Pain Scale, Linalool, Linalyl Acetate

Antihypertensive Drug Use in Patient With Intracerebral Hemorrhage Stroke Luh Putu Febryana Larasanty
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Intracerebral hemorrhage (ICH) stroke is a type of stroke with the highest mortality rate, with only about 38% of patients who survived for the first year after stroke. Antihypertensive treatment one of the main therapy for reduce the mortality rate in ICH. Based on review from research study journals, peer review journals, guidelines or book about use of antihypertensive drugs in ICH stroke patient and/or hypertensive emergency, uses of nicardipine, labetalol, esmolol and enalapril can be as the first-line therapy to manage acute high blood pressure in intracerebral hemorrhage stroke if there is no contraindication or caution is present. Nicardipine, labetalol, esmolol and enalapril is four agent that reduce blood pressure in a titratable fashion and do not lead increases in intracranial pressure. Hydralazine, sodium nitroprusside and nitroglycerine can be used as alternative agent if nicardipine, labetalol, esmolol and enalapril can not be used in ICH stroke patient. Keywords: Stroke, Intracerebral Hemorrhage, Antihypertensive Agent

EFFECTIVENESS OF BRONCHODILATOR AND CORTICOSTEROID TREATMENT IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) Putu Rika Veryanti; Ainun Wulandari
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway disease which is characterized by progressive airway obstruction. Bronchodilators and corticosteroids are the first choices of therapy in COPD patients. The goal therapy of COPD patients is to prevent respiratory failure, which can impact on death. But nowadays, the mortality rate due to COPD continues to increase. WHO predicts mortality from COPD in the year 2030 will be ranked third in the world. This high mortality can be caused by the ineffectiveness of therapy given. Objective: The aim of this study is to find out the effectiveness of bronchodilator and corticosteroid treatments in COPD patients. Methods: An observational study conducted retrospectively in the 2018 period at Fatmawati Central General Hospital. The effectiveness of therapy was assessed from the patient's clinical condition, blood gas values (PaO2 & PaCO2) and the average length of stay (AvLOS). Results: COPD was mostly suffered by males (83,33%), and the highest age for COPD was in the range of 45 years and above (90%). Bronchodilator that commonly prescribed were albuterol (30.08%), ipratropium bromide (12.2%), fenoterol hydrobromide (10.57%), terbutaline sulfate (8.13%), theophylline (1.63%) and aminophylline (5.69%), while the corticosteroids were budesonide (17.07%), methylprednisolone (9.76%) and dexamethasone (4.88%). Bronchodilator and corticosteroid had improved patient's clinical condition (96.67% patients) and also improved PaO2 & PaCO2 values patients. There was a significant improvement in PaO2 and PaCO2 value in COPD patients (p <0.05). Conclusion: Bronchodilator and corticosteroid in COPD patients had improved patient's clinical condition and PaO2 & PaCO2 values, but the average length of stay exceeds the standard (6-9 days). Keywords: Bronchodilator, Corticosteroid, COPD, Blood Gas Analysis, Average Length of Stay

Chitosan Reinforced Alginate Microcapsules Retained The Release of Papain in Simulated Gastric Fluid C.I.S. Arisanti; H. Rachmawati; J.S. Pamudji; Y.C. Sumirtapura
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Alginate microcapsules were obtained by emulsification/internal gelation technique was chosen as carrier papain and the potential use as an oral controlled release system investigated. Chitosan was then applied as a membrane coat to increase the mechanical and stabilize the microcapsules in simulated gastric fluid. Papain microcapsules consisted of particle size distribution, morphology, entrapment efficiency of papain in the microspheres and release study. The release study was performed in various pHs with or without proteolitic enzyme. Narrow particle size distribution with average of 315-560 ?m was obtained from microcapsule prepared with water/oil ratio of 30 : 70, acid/CaCO3 molar ratio of 6 : 1 and agitation speed of 400 rpm. Papain microcapsule with that composition has entrapment efficiency of 95.79%. The release of papain from the alginate-chitosan microcapsule took place trough diffusion and relaxation of polymer at pH 1.2-4.5. The in vitro release studies showed that alginate-chitosan complex formation reduce erosion of alginate-chitosan matrix at pH 6.8. Both pepsin and pankreatin increased release of papain. Alginate-chitosan polyelectrolyte complex occurred on the surface of papain microcapsule controlled the release of papain from microcapsule. The presence of chitosan on the surface of microcapsule retained the release of papain in undesired site (gastric). In conclusion, papain microcapsule developed in this study is suggested to be appropriate approach for oral delivery of papain. Keywords : papain, microcapsules, alginate, chitosan, pepsin, pankreatin

STABILITY COMPARISON OF TULASI (Ocimum tenuiflorum L.) LEAF GEL HAND SANITIZER USING 0.5% AND 1% CMC-Na Dewa Ayu Made Adnya Swari; Ni Putu Udayana A; Ni Made Dharma Shantini S
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: Hand sanitizers contain 62% alcohol, softener and moisturizer. High alcohol content is able to irritate and make hands dry. A suitable moisturizer is needed for this preparation. Objective: The aim of this study is to evaluate the physical quality of gel hand sanitizer formulation of Ocimum tenuiflorum with CMC-Na as a gelling agent at a concentration of 0.5% and 1% CMC-Na. Methods: Data were collected at week-0,1,2,3,4, and replication is performed three times at each concentration of each measurement. The test results of the spread and adhesion data analysis using SPSS with a 95% confidence level. Results: Dispersive power and adhesion showed no significant difference (p <0.05) at week 0 and week 4 means second-hand sanitizer gel formulation concentration is not stable. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) at a concentration of 1% CMC-Na stable from week 0 to week 3, while the concentration of 0.5% CMC-Na change at week 2. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) with a gelling agent CMC-Na should need to be titrated. Conclusion: Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) that use concentrations of 1% CMC-Na as a gelling agent have a physical quality that is more stable than the organoleptic test concentration of 0.5% CMC-Na. Keywords: Hand sanitizer, Ocimum tenuiflorum L., CMC-Na, Physical quality evaluation

Antibiotics Drug Use Evaluation Among Patients With Kidney Disorder in PKU Muhammadiyah Hospital of Yogyakarta Agung Endro Nugroho; Fentyana Dwi Rilawati; Inayati Inayati
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Antibiotic that appropriately as used anti-infective has drug a great success in reducing morbidity and mortality rates resulted from various infectious diseases, leading its increasing usage. Antibiotic are generally eliminated through kidney. Patients with kidney disorder, dosage adjustment is recommended for certain antibiotics. This research aims at evaluating the use of antibiotics among patients with kidney disorder in the inpatient wards of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done retrospectively based on medical record data of inpatients meeting both inclusion and exclusion criteria in PKU Muhammadiyah Hospital Yogyakarta. Data processing was done by using a descriptive analytical technique. Result of the study shows that there were 76 patients with kidney disorder using antibiotics and meet inclusion and exclusion criteria. In this study patients wasn’t shown an indications of infection is aproximately 75,00% (57 patients) and patient with indication infection were 25,00% (19 patients). From those who have an appropriate indication, it is just 21,05% (16 patient) have an appropriate medication, 23,68% (18 patient) is right patient and 22,37% (17 patient) have an appropriate doses. Clinical outcome of those 19 patient is good (14 patient) with inpatient duration less than 7 days for 12 patient. Total 76 patient with renal disorder who received antibiotics, 21,05% (16 patients) have inappropriate doses which is mean there is no doses adjusment according to the creatinine clearance of each patient. Keywords: Antibiotics, kidney disorders, rational drug, dose

Effect of Extraction Systems of Cannabinoid From Cannabis Sp on TLC Densitometric Chromatogram Pattern N.M.P. Susanti; M.A.G. Wirasuta; I. N. K. Widjaja; K.W. Astuti; N.L.P.V. Paramita
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Optimization studies of cannabinoid extraction method of Cannabis sp have been conducted. The aim of this study was to find a marijuana extraction method to identify cannabinoid compounds using TLC–Spectrophotodensitometry technique. This study covers the process of maceration and soxhlet extraction to extract cannabinoid content in marijuana flowers and seeds using methanol PE, and ether as a solvent, followed by a screening test using the TLC- Spectrophotodensitometry method. Confirmation test used Fast Blue B salt to visualize color of the spots. CBN, THC, and CBD can be separated by either using the stationary phase of Al-TLC SI G60 F254 with a mobile phase of hexane - diethylether with the color visualization and Rf value after spraying with Fast Blue B Salt are the CBN will provide the purple-pink color with the HRF 59, THC will provide the purple color with the HRF 66, and the CBD will give orange color with the HRF 73 [1,2]. These results indicate that CBN, THC and CBD can be separated by either using the Al-TLC SI G60 F254 system with a mobile phase of hexanediethylether (80: 20, v / v). Differences in extraction methods affect the pattern of TLCDensitometry chromatogram peak. This effect on the profiling of simplicia. Keywords: extraction, cannabinoid, Al-TLC, Spectrophotodensitometry

ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans Dewa Ayu Made Adnya Swari; I Wayan Martadi Santika; I Gusti Made Aman
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and post-test design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b / v) Keywords: Antifungal activity, Candida albicans, Rosemary, RTPase, ethanol extract

Study of free/total morphine-ratio in blood after heroin intake as a tool to predict the outcome of heroin-intoxication I M.A.G. Wirasuta; H.-J. Duchstein; H. Kijewski
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

The time course of free/total morphine ratio (f/t M-ratio) after i.v. heroin administration in both healthy people and patients with liver or renal insufficiency was pharmacokinetically simulated. In the 502 cases of heroin consumption investigated in this study, the morphine blood levels and f/t M-ratio were registered, arranged, and statistically analysed. Total morphine blood levels in survivors and non survivors were 0.010-3.900 ?g/ml (with 0-0.275 ?g/ml of free morphine) and 0.010-8.570 ?g/ml (with 0-2.200 ?g/ml of free morphine), respectively. Therefore the respective ranges of f/t M-ratiolevels in survivors and in lethal cases were 0-0.786 and 0-0.935. Based on this simulation, the f/t M-ratio after heroin injection was determined by the time elapsed since the last dose and individual pharmacokinetics of heroin and its metabolites. This ratio is independent to the heroin dose. Keywords : Heroin; Morphine; Lethal intoxication; Pharmacokinetic simulation

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Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Made Krisna Adi Jaya

Contact Email krisnaadijaya598@gmail.com

Phone +6281293208990

Journal Mail Official jpsa@unud.ac.id

Editorial Address Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA