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Journal Pharmaceutical Science and Application (JPSA)

jpsa
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Published by Universitas Udayana

ISSN : 23017694 EISSN : 23017708 DOI : https://doi.org/10.24843/JPSA.2020.v02.i01

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Journal of Pharmaceutical Sciences and Applications (JPSA) is an online and print out Journal. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmaceutical sciences and applications. Pharmaceutical Technology Pharmacognosy Natural Product Research Pharmaceutics Novel Drug Delivery Biopharmaceutics Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology Genomics and Proteomics Pharmacogenomics Bioinformatics and Biotechnology The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal. Journal of Pharmaceutical Scince and Application (JPSA), a half yearly publication, serves the need of different scientists and others involved in Pharmaceutical science research and application. All contribution to JPSA are reviewed by peer review process and copy editing process with the understanding that they have not been published previously and are not under consideration for publication elsewhere.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 6 Documents

Search results for , issue "Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application" : 6 Documents clear

Diffusion of Sodium Diclofenac from Carbopol 940 Gel at Various pH Ketut Widyani Astuti; Yeyet C. Sumirtapura; Ni Nyoman Wiwik S
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Diffusion of sodium diclofenac in Carbopol 940 gel has been investigated. Diffusion test was performed in diffusion cells with artificial membranes of Whatman no.1 filter paper which immersed with Spangler solution. Measurement of active ingredient concentration that diffuses was performed using UV spectrophotometer at a wavelength of 277 nm. The results showed that diffusion rate of sodium diclofenac from Carbopol gel increased at higher pH. The highest diffusion of diclofenac sodium occurs at pH 8 with a mean percentage of diclofenac sodium which diffuses after 240 minutes was 48.06 + 4.83%. The mean percentage of diclofenac sodium which diffuses from the gel Carbopol 940 at pH 6 after 240 minutes was 11.47 + 1.71% while the Carbopol 940 gel at pH 7 is 22.44 + 3.71%. Keywords: diffusion, diclofenac sodium, pH, gel Carbopol 940

Antihypertensive Drug Use in Patient With Intracerebral Hemorrhage Stroke Luh Putu Febryana Larasanty
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Intracerebral hemorrhage (ICH) stroke is a type of stroke with the highest mortality rate, with only about 38% of patients who survived for the first year after stroke. Antihypertensive treatment one of the main therapy for reduce the mortality rate in ICH. Based on review from research study journals, peer review journals, guidelines or book about use of antihypertensive drugs in ICH stroke patient and/or hypertensive emergency, uses of nicardipine, labetalol, esmolol and enalapril can be as the first-line therapy to manage acute high blood pressure in intracerebral hemorrhage stroke if there is no contraindication or caution is present. Nicardipine, labetalol, esmolol and enalapril is four agent that reduce blood pressure in a titratable fashion and do not lead increases in intracranial pressure. Hydralazine, sodium nitroprusside and nitroglycerine can be used as alternative agent if nicardipine, labetalol, esmolol and enalapril can not be used in ICH stroke patient. Keywords: Stroke, Intracerebral Hemorrhage, Antihypertensive Agent

Chitosan Reinforced Alginate Microcapsules Retained The Release of Papain in Simulated Gastric Fluid C.I.S. Arisanti; H. Rachmawati; J.S. Pamudji; Y.C. Sumirtapura
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Alginate microcapsules were obtained by emulsification/internal gelation technique was chosen as carrier papain and the potential use as an oral controlled release system investigated. Chitosan was then applied as a membrane coat to increase the mechanical and stabilize the microcapsules in simulated gastric fluid. Papain microcapsules consisted of particle size distribution, morphology, entrapment efficiency of papain in the microspheres and release study. The release study was performed in various pHs with or without proteolitic enzyme. Narrow particle size distribution with average of 315-560 ?m was obtained from microcapsule prepared with water/oil ratio of 30 : 70, acid/CaCO3 molar ratio of 6 : 1 and agitation speed of 400 rpm. Papain microcapsule with that composition has entrapment efficiency of 95.79%. The release of papain from the alginate-chitosan microcapsule took place trough diffusion and relaxation of polymer at pH 1.2-4.5. The in vitro release studies showed that alginate-chitosan complex formation reduce erosion of alginate-chitosan matrix at pH 6.8. Both pepsin and pankreatin increased release of papain. Alginate-chitosan polyelectrolyte complex occurred on the surface of papain microcapsule controlled the release of papain from microcapsule. The presence of chitosan on the surface of microcapsule retained the release of papain in undesired site (gastric). In conclusion, papain microcapsule developed in this study is suggested to be appropriate approach for oral delivery of papain. Keywords : papain, microcapsules, alginate, chitosan, pepsin, pankreatin

Antibiotics Drug Use Evaluation Among Patients With Kidney Disorder in PKU Muhammadiyah Hospital of Yogyakarta Agung Endro Nugroho; Fentyana Dwi Rilawati; Inayati Inayati
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Antibiotic that appropriately as used anti-infective has drug a great success in reducing morbidity and mortality rates resulted from various infectious diseases, leading its increasing usage. Antibiotic are generally eliminated through kidney. Patients with kidney disorder, dosage adjustment is recommended for certain antibiotics. This research aims at evaluating the use of antibiotics among patients with kidney disorder in the inpatient wards of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done retrospectively based on medical record data of inpatients meeting both inclusion and exclusion criteria in PKU Muhammadiyah Hospital Yogyakarta. Data processing was done by using a descriptive analytical technique. Result of the study shows that there were 76 patients with kidney disorder using antibiotics and meet inclusion and exclusion criteria. In this study patients wasn’t shown an indications of infection is aproximately 75,00% (57 patients) and patient with indication infection were 25,00% (19 patients). From those who have an appropriate indication, it is just 21,05% (16 patient) have an appropriate medication, 23,68% (18 patient) is right patient and 22,37% (17 patient) have an appropriate doses. Clinical outcome of those 19 patient is good (14 patient) with inpatient duration less than 7 days for 12 patient. Total 76 patient with renal disorder who received antibiotics, 21,05% (16 patients) have inappropriate doses which is mean there is no doses adjusment according to the creatinine clearance of each patient. Keywords: Antibiotics, kidney disorders, rational drug, dose

Effect of Extraction Systems of Cannabinoid From Cannabis Sp on TLC Densitometric Chromatogram Pattern N.M.P. Susanti; M.A.G. Wirasuta; I. N. K. Widjaja; K.W. Astuti; N.L.P.V. Paramita
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Optimization studies of cannabinoid extraction method of Cannabis sp have been conducted. The aim of this study was to find a marijuana extraction method to identify cannabinoid compounds using TLC–Spectrophotodensitometry technique. This study covers the process of maceration and soxhlet extraction to extract cannabinoid content in marijuana flowers and seeds using methanol PE, and ether as a solvent, followed by a screening test using the TLC- Spectrophotodensitometry method. Confirmation test used Fast Blue B salt to visualize color of the spots. CBN, THC, and CBD can be separated by either using the stationary phase of Al-TLC SI G60 F254 with a mobile phase of hexane - diethylether with the color visualization and Rf value after spraying with Fast Blue B Salt are the CBN will provide the purple-pink color with the HRF 59, THC will provide the purple color with the HRF 66, and the CBD will give orange color with the HRF 73 [1,2]. These results indicate that CBN, THC and CBD can be separated by either using the Al-TLC SI G60 F254 system with a mobile phase of hexanediethylether (80: 20, v / v). Differences in extraction methods affect the pattern of TLCDensitometry chromatogram peak. This effect on the profiling of simplicia. Keywords: extraction, cannabinoid, Al-TLC, Spectrophotodensitometry

Study of free/total morphine-ratio in blood after heroin intake as a tool to predict the outcome of heroin-intoxication I M.A.G. Wirasuta; H.-J. Duchstein; H. Kijewski
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

The time course of free/total morphine ratio (f/t M-ratio) after i.v. heroin administration in both healthy people and patients with liver or renal insufficiency was pharmacokinetically simulated. In the 502 cases of heroin consumption investigated in this study, the morphine blood levels and f/t M-ratio were registered, arranged, and statistically analysed. Total morphine blood levels in survivors and non survivors were 0.010-3.900 ?g/ml (with 0-0.275 ?g/ml of free morphine) and 0.010-8.570 ?g/ml (with 0-2.200 ?g/ml of free morphine), respectively. Therefore the respective ranges of f/t M-ratiolevels in survivors and in lethal cases were 0-0.786 and 0-0.935. Based on this simulation, the f/t M-ratio after heroin injection was determined by the time elapsed since the last dose and individual pharmacokinetics of heroin and its metabolites. This ratio is independent to the heroin dose. Keywords : Heroin; Morphine; Lethal intoxication; Pharmacokinetic simulation

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Reviewer

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Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Made Krisna Adi Jaya

Contact Email krisnaadijaya598@gmail.com

Phone +6281293208990

Journal Mail Official jpsa@unud.ac.id

Editorial Address Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Made Krisna Adi Jaya

Contact Email
krisnaadijaya598@gmail.com

Phone
+6281293208990

Journal Mail Official
jpsa@unud.ac.id

Editorial Address
Gedung AF Jalan Kampus Udayana, Bukit Jimbaran Badung - Bali Indonesia 80239 Phone: +62 361 4747 770

Location
Kota denpasar,

Bali

INDONESIA