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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
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Articles 13 Documents
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Search results for , issue "Vol. 10, No 1, Tahun 2021" : 13 Documents clear
Aktivitas Antioksidan Ekstrak Etanol Kayu Manis (Cinnamomum burmani) Secara In Vitro / Antioxidant Activities Of Cinnamon (Cinnamomum burmani) In Vitro Irma Antasionasti; Jayanto I
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p05

Abstract

ABSTRAK Kayu manis (Cinnamomum burmani) merupakan rempah-rempah yang bisa dijadikan sebagai bahan tambahan dalam makanan dan juga kue serta salah satu bahan farmasi dalam industri farmasi. Oleh karena itu, eksplorasi kayu manis sebagai antioksidan alami sangat diperlukan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan kayu manis menggunakan uji DPPH, ABTS dan daya aktivitas reduksi besi III serta total fenolik dan total flavonoid. Kayu manis bubuk diekstraksi menggunakan teknik maserasi dengan pelarut etanol 96% dan dilakukan pengujian aktivitas antioksidan. Ekstrak etanol kayu manis menunjukkan nilai aktivitas antioksidan DPPH, ABTS, dan reduksi besi III secara berturut-turut sebesar 1,939 ± 0,055 ?g/mL; 2,235 ± 0,014 ?g/mL; dan 1415,705 ± 38,609 mg asam askorbat/gram ekstrak. Aktivitas antiradikal ekstrak etanol kayu manis lebih rendah dibandingkan dengan vitamin C yaitu 0,554 ± 0,003 ?g/mL (DPPH) dan 0,813 ± 0,028 ?g/mL (ABTS). Aktivitas antioksidan yang diberikan oleh ekstrak etanol kayu manis dipengaruhi oleh kandungan total fenolik dan total flavonoid secara berturut-turut sebesar 75,685 ± 1,408 % EAG dan 60,546 ± 0,670 % EK. Kayu manis memiliki aktivitas antioksidan yang sangat kuat, mengandung total fenolik dan total flavonoid dalam jumlah tinggi sehingga berpotensi sebagai bahan tambahan pangan (antioksidan) dalam industri makanan maupun farmasi.
Analisis Cemaran Kapang/Khamir Pada Serbuk Simplisia Obat Tradisional Resmila Dewi; Nur RM
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p10

Abstract

Folk remedies are of great benefit to well being and are now being used as they are easier to access. The raw materials used for such products are plant products, animal materials, mineral materials, or mixtures. Parts of plants widely used are roots, rhizomes, branches, fruits, leaves, seeds, and bark. These ingredients are used in both fresh and dry (simplicia) form. Simplicia storage under unregulated conditions will lead to the presence of different types of microorganisms, particularly mold. This research aims at examining the extent of mold/yeast contamination in the simplicity of conventional medicinal plants. The samples used in this analysis were Turmeric rhizome, Curcuma rhizome, ginger rhizome, Sambiloto leaf, and god's crown fruit. Simplicia had been collected from five Aceh Conventional Market traders. Testing sample time bar contamination using cup technique for spreading plate method on PDA media. The results showed that AKK simplicia rhizomes turmeric 46—120 colonies/grams, rhizomes Curcuma 50—96 colonies/grams, ginger rhizomes 23—43 colonies/grams, 46—100 colonies/grams of Sambiloto leaves and 43—83 colonies/grams of god crown berries. This is less than the number of mold/yeast set by BPOM (104 colonies/g).
Pengaruh Variasi Metode Ekstraksi Terhadap Perolehan Senyawa Antioksidan Pada Daun Katuk (Sauropus androgynus (L.) Merr) Ni Putu Ermi Hikmawanti; Sofia Fatmawati; Zainal Arifin; Vindianita .
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p01

Abstract

S. androgynus (Phyllanthaceae) contains natural antioxidant compounds such as phenolics and flavonoid derivatives. The successful to obtain the plant metabolite compounds depends on the extraction method. This study aims to determine the total phenolics and flavonoids content of the ethanolic extract of S. androgynus leaves obtained from three types of extraction methods, namely maceration, Soxhletation, and ultrasonic. Determination of total phenolics and flavonoids content was carried out by colorimetric method using Folin-ciocalteu and AlCl3 10% reagents, respectively. The absorbance of the reaction was measured using a UV-Vis spectrophotometer. Total phenolics content is expressed as equivalent to gallic acid, while total flavonoid content is expressed as equivalent to quercetin. Determination of the extract's antioxidant activity was carried out against DPPH free radical and expressed by the IC50 (ppm) value. The results showed that the ultrasonic extraction method produced the best levels of phenolics (42.96 ± 0.51 mgGAE/g), flavonoids (12.05 ± 0.36 mgQE/g) and antioxidant activity (IC50 = 81.43 ± 2.63 ppm) in ethanolic extract of S. androgynus leaves compared to another extraction method (maceration > Soxhletation). Thus, it can be concluded that the ultrasonic extraction method is an efficient and effective extraction method to produce high antioxidant compounds in ethanolic extract of S. androgynus leaves.
Perbandingan Kualitas Layanan Kefarmasian Di Puskesmas Berstandar ISO dan Non-ISO Kota Denpasar Made Krisna Adi Jaya; Ni Luh Santiyani Dewi; I Gusti Lanang Made Rudiartha
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p06

Abstract

Background: Primary Health Care (puskesmas in Indonesian) is a facilities/infrastructure used to improve health status and health development. Pharmaceutical services at puskesmas are always in the spotlight of the community and tend to be negative in stigma. The community paradigm, especially in Denpasar, tends to state that pharmaceutical services at ISO-standard puskesmas are better than non-ISO. However, this does not mean that non-ISO health centers in Denpasar City do not provide optimal services to the community. Based on this problem, research needs to be conducted to assess the extent of differences in the quality of pharmaceutical services in ISO and non-ISO health centers in Denpasar. Objective: This study aims to compare the quality of pharmaceutical services in ISO and non-ISO puskesmas including the waiting time for drug services, the incidence of Drug Related Problems (DRP), and the level of patient satisfaction. Methods: An analytic observational study was conducted by observing 184 respondents who used the health services at the puskesmas in Denpasar. Waiting time was observed from the patient submitting a prescription until getting the medicine; DRP was observed by the number of drug interactions, patient adherence to therapy and the incidence of Adverse Drug Reaction (ADR); and patient satisfaction using the satisfaction questionnaire. Results: The waiting time for drug services showed that the ISO puskesmas was superior to non-ISO (p <0.05) while the DRP incidence and patient-related satisfaction were not significantly different (p> 0.05). Conclusion: Non-ISO Puskesmas in Denpasar showed the quality of pharmaceutical services that were comparable to Puskesmas with ISO standards. Keywords: Drug Services, Drug Related Problem, Patients Satisfaction, Primary Health Care
Pengaruh Variasi Konsentrasi Natrium Klorida dalam Formulasi Sediaan Facial Wash Kombinasi Ekstrak Spirulina (Spirulina platensis )dan Minyak Nyamplung (Chalophyllum inophyllum) anif nur artanti; Prabawati N; Prihapsara F; Rakhmawati R
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p11

Abstract

Spirulina platensis diketahui mengandung fikosianin yang berpotensi sebagai antioksidan dan pewarna alami. Minyak nyamplung merupakan bahan baku kosmetik yang belum banyak digunakan. Minyak nyamplung berkhasiat sebagai antibakteri dan antioksidan, sehingga berpotensi untuk dibuat sediaan kosmetik salah satunya facial wash. Penelitian ini dilakukan untuk mengetahui pengaruh variasi konsentrasi NaCl terhadap sifat fisik sediaan facial wash ekstrak spirulina dan minyak nyamplung. Penelitian dilakukan dengan metode eksperimental laboratorium dengan tahapan pembuatan basis sabun, pembuatan facial wash dengan tiga variasi konsentrasi NaCl 1%; 2%; dan 3%, serta uji sifat fisik dan kimia berupa uji organoleptik, uji viskositas, uji stabilitas busa, dan uji pH. Kemudian hasil pengujian organoleptik, uji pH, uji viskositas, uji stabilitas busa dibandingkan dengan Standar Nasional Indonesia dan literatur lainnya. Hasil penelitian menunjukkan bahwa variasi konsentrasi NaCl memberikan pengaruh signifikan terhadap sifat fisik sediaan, yaitu semakin tinggi konsentrasi NaCl maka viskositas semakin meningkat namun stabilitas busa semakin menurun. Formula 3 dengan konsentrasi NaCl 3% merupakan formula facial wash ekstrak spirulina dan minyak nyamplung yang paling stabil.
Produk Inovasi Aromaterapi Berbasis Minyak Atsiri Kemenyan, Kamfer Sumatera Dan Ekaliptus Cut Rizlani Kholibrina; Aswandi Aswandi
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p02

Abstract

The global pandemic Covid-19 encourages peoples to improve their immune system. Both healthy food and regular exercise, good immunity can be achieved from healthy and relaxing mind, including through aromatherapy. This is in line with increasing awareness in holistic and organic medicine. The objectives of study are to develop aromatherapy products based-on sumatran camphor, styrax, and eucalypts essential oils; and to identify consumer preferences for innovation products. A conjoint analysis was operated to determine consumer preferences. The active compounds contained in essential oils combination are including a-pinene, 1.8-cineole, limonene, b-caryophyllene and p-cymene. The combination and presence of similar active compound harmonize aroma with minimal contraindications and produce refreshing and relaxing aromas. The 1.8-cineole is known as anti-fungal, antiviral which offer relief to congested respiratory system, thereby boosts immune system. Moreover, p-cymene has been identified to reduce anxiety, nervousness, and relaxing the mind. Based on conjoint analysis, aroma has the greatest influence on consumer preferences. The most preferred profile is aromatherapy product which soft-refreshing aroma, roll-on package, volume 6 ml, at price of Rp 35,000. Aroma is influenced by personal’s perceptions, which related to initial recognition of certain scents as olfactory memory.
Terapi Fibrinolitik Pada Pasien St-Segment Elevation Myocardial Infarction (Stemi) : Review Artikel Irma Novrianti; Heriani .; Mustamin F
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p07

Abstract

Acute ST-elevation myocardial infarction (STEMI) occurs when there is a blockage caused by sudden atherosclerotic plaque that blocks blood flow to the heart. The goal of STEMI therapy is to restore myocardial blood flow, to save the heart. Coronary arterial reproduction recommended by the American Heart Association (AHA) and the Indonesian Cardiovascular Specialist Association (PERKI) is primary percutaneous coronary intervention (PCI) or fibrinolytic. However, not all hospitals have catheterization laboratory facilities, so they still use fibrinolytic as reperfusion therapy. To provide a review of currently available fibrinolytic therapies that can be used in STEMI patients. Four databases [Pubmed, Libgen, researchgate, and Scopus] were searched from 1987 to 2019. Include original articles including RCT, comparative, literature review, and observational study about fibrinolytics treatment in Acute STEMI. Fibrinolytic was divided into specific fibrin (alteplase, tenecteplase, and reteplase) and non-specific fibrin (streptokinase and urokinase). Fibrinolytic used in STEMI are streptokinase, alteplase, tenecteplase, and reteplase. Fibrinolytic can be given when the patient has no contraindications. Furthermore, the administration must follow protocols to minimize the risk of side effects such as bleeding. Fibrinolytic can be used as reperfusion therapy in STEMI patients when PCI cannot be done promptly.
Kadar Kalium dalam buah Pisang Ambon Tuty Taslim; Salim R; Monica T
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p12

Abstract

Pisang ambon merupakan salah satu jenis pisang dan buah meja yang digemari oleh masyarakat. Pisang ambon mengandung kadar kalium yang disarankan untuk menjaga kestabilan tekanan darah sehingga dapat mencegah penyakit hipertensi bagi pra lansia. Akhir-akhir ini selain daging buah pisang ambon yang dimanfaatkan, kulit buah pisang ambon juga telah diolah dengan sebaik mungkin untuk dikonsumsi sebagai salah satu usaha pemenuhan kadar kalium bagi manusia. Hal ini memberikan ide untuk meneliti perbedaan signifikan kadar kalium pada daging dan kulit buah pisang ambon. Penelitian ini dilakukan dengan cara mengambil sampel secara non probability accidental. Sampel yang diambil didestruksi basah dan diukur kadar kaliumnya menggunakan Spektrofotometer Serapan Atom (SSA). Hasil penelitian memberikan data kadar kalium daging dan kulit buah pisang ambon berturut-turut adalah 359,19 dan 882,38 mg/100 gram. Perbedaan kadar kalium yang didapat dianalisis menggunakan Independent T-Test SPSS memberikan nilai signifikansi ? < 0,05 yang artinya perbedaan kadar kalium pada daging dan kulit buah pisang signifikan.
Penentuan Kadar Flavonoid Total Ekstrak Etanol Jamur Susu Harimau (Lignosus rhinocerus) Dina Yuspita Sari; Widyasari R; Taslima AN
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p03

Abstract

ABSTRAK Jamur susu harimau (Lignosus rhinocerus) merupakan tanaman yang digunakan dalam pengobatan tradisional di pedalaman Kalimantan Barat terutama di Kapuas Hulu. Salah satu konstituen fitokimia yang terkandung adalah flavonoid (flavon dan flavanon). Penelitian ini bertujuan untuk menentukan kadar flavonoid total pada ekstrak etanol jamur susu harimau. Simplisia jamur susu harimau dimaserasi menggunakan etanol 96 %. Skrining fitokima terhadap keberadaan flavonoid dalam ekstrak menggunakan serbuk magnesium dan amil alkohol. Penentuan kadar flavonoid total pada ekstrak etanol jamur susu harimau dilakukan secara spektrofotometri UV-Vis dengan metode kolorimetri (AlCl3) pada ? 410 nm dan dinyatakan sebagai flavonoid total dalam ekuivalen kuersetin (EQ). Kadar flavonoid total pada ekstrak etanol jamur susu harimau adalah sebesar 33,041 mgEQ/g ekstrak. Ekstrak etanol jamur susu harimau yang mengandung flavonoid berpotensi sebagai sumber antiooksidan alami dan potensial untuk dikembangkan dalam produk obat dan kosmetik. Kata kunci: Jamur susu harimau, kadar flavonoid total, kolorimetri.
Fortifikasi Antioksidan Beras Analog Kombinasi Ubi Jalar (Ipomoea batatas L.) dan Kelor (Moringa oleifera) sebagai Upaya Diversifikasi Pangan Penderita Diabetes Melitus I Made Arie Dharma Putra Nugraha; I Made Sasmita Dwidhananta; Ni Kadek Diah Parwati Dewi; I Made Agus Gelgel Wirasuta
Jurnal Farmasi Udayana Vol. 10, No 1, Tahun 2021
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2021.v10.i01.p08

Abstract

Introduction: Diabetes mellitus (DM) is classified as a silent killer in society. Insulin therapy is generally the management of DM, morever there is a side effect of weight gain from hypoglicemic effects. Another solution is a low glycemic index food diet in analogue rice form. The materials constructed as analogue rice are sweet potato tubers (Ipomoea batatas L.), with high dietary fiber and low glycemic index, as well as antioxidant fortification of Moringa oleifera leaves. Objectives: Updating the latest knowledge on the chemical composition of raw materials and health benefits for people with diabetes, along with analogue rice making technology in order to get the best results. Methods: This study was conducted with a literature review method which is classified as a systematic qualitative descriptive study. Results: Various studies have shown that both raw materials are reported to have various chemical compounds and nutritional components, low glycemic index, antioxidant activity, and anti-DM. Hot extrusion technology provides the best results in making analogue rice. Conclusion: The analogue rice production made from sweet potato tubers and antioxidant fortification of moringa leaves by hot extrusion are used to produce functional herbal products as a result to diversify the food for DM sufferers. Keywords: Ipomoea batatas L., Moringa oleifera, analog rice, fortification, and diabetes mellitus

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