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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
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Articles 12 Documents
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Search results for , issue "Vol. 12, No 1, Tahun 2023" : 12 Documents clear
PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN Ilhammudin Sirait; Husnarika Febriani; Syukriah -
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p05

Abstract

A metabolic condition called diabetes mellitus (DM) results from an inability to secrete insulin. The purpose of this study is to determine the impact of ethanol extract from karanda leaves (Carissa carandas L.) on diabetes mellitus mouse kidney morphology and renal histology. The study employed a complete random design (RAL) with the partition of variants into 6 groups, including normal control, negative control, glibenklamid group, and P1: karanda leaf extract doses of 500 mg/kg BB, 750 mg/kg BB, and 1000 mg/kg BB. hematoxylin-eosin (HE) staining and the paraffin method for producing mouse kidney histopathology preparations. Data analysis using the one-way Anova and the sophisticated tests of Duncan. The outcomes demonstrated that the kidneys of diabetic mice in the control and treatment groups had significantly different morphologies and histopathologies. The glomerulus was edematous in diabetic kidneys with melitus, and cell damage manifested as hydropic degeneration, necrosis of the proximal tubules, and variations in glomerular diameter. The administration of ethanol-extracted from karanda leaves can help with glomerular edema, shape, and cell healing in the proximal tubules. Conclusion: Caranda leaf ethanol extract improves the morphology, renal histology, and glomerular diameter of mice (Rattus norvegicus) with diabetic mellitus, with 1000 mg/kgbb of extract being the most efficacious dose. Keywords: Diabetes Mellitus, Karanda Leaf (Carissa carandas L.) and Kidneys
Review potensi Emblica officinalis (Amla) dalam mengatasi gangguan metabolisme dislipidemia dan antioksidan Ni Kadek Warditiani; Pande Made Nova Armita Sari; Ni Made Widi Astuti; I Made Agus Gelgel Wirasuta
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p10

Abstract

Emblica officinalis (Amla) is a plant that is not widely utilized in Bali, but it has tremendous potential. This study aims to investigate the antioxidant and anti-dyslipidemia potential of Amla. Literature search was conducted on Pubmed, Scopus, and Science Direct, followed by screening and review to match the inclusion and exclusion criteria. The search resulted in 346 articles, and after reviewing and screening the titles, keywords, and abstracts, 12 articles that met the criteria were obtained. The review findings indicate that Emblica officinalis (Amla) has a strong potential in preventing or addressing cardiovascular disorders such as atherosclerosis due to its abilities as a potential anti-dyslipidemia and antioxidant agent.
Aktivitas Anti-Wrinkle Gel Ekstrak Binahong (Anredera cordifolia) secara In Vivo Kintoko Kintoko; Hardi Astuti Witasari; Yuda Fajar Pratama
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p01

Abstract

Sinar ultraviolet memicu terbentuknya radikal bebas penyebab kerutan. Daun binahong (Anredera cordifolia) memiliki aktivitas antioksidan yang dapat menstabilkan radikal bebas. Penggunaan ekstrak daun binahong dalam bentuk gel lebih praktis dan nyaman dikulit. Penelitian ini bertujuan untuk mengetahui aktivitas anti-wrinkle pemberian gel ekstrak binahong pada mencit yang diinduksi sinar UV-B. Penelitian ini menggunakan 25 ekor mencit jantan, dibagi 5 kelompok. Kelompok normal (perlakuan apapun), kelompok UV-B (hanya paparan sinar UV-B), kelompok tretinoin (paparan sinar UV-B dan gel tretinoin), kelompok perlakuan 1 (paparan sinar UV-B dan gel ekstrak binahong satu kali sehari), kelompok perlakuan 2 (paparan sinar UV-B dan gel ekstrak binahong dua kali sehari. Paparan dilakukan dengan lampu UV-B Kernel KN-4003 selama 2 minggu. Pengamatan kerutan secara visual scoring dengan metode Bissett. Data yang diperoleh dianalisis menggunakan uji statistik SPSS. Skor kerutan pada kelompok normal adalah 0, kelompok UV-B 2,66±0,48, kelompok tretinoin 0,44±0,38, kelompok perlakuan 1 1,06±0,61, dan kelompok perlakuan 2 0,80±0,84. Kelompok UV-B memberikan perbedaan yang signifikan terhadap tretinoin, perlakuan 1, dan 2 (P<0,05). Kelompok tretinoin tidak berbeda signifikan terhadap skor kerutan pada perlakuan 1 dan 2 (P>0,05). Pemberian gel ekstrak binahong memiliki aktivitas sebagai anti-wrinkle dalam mencegah terjadinya kerutan pada mencit yang diinduksi sinar UV-B. Penambahan frekuensi memberikan perbedaan yang tidak signifikan. Kata kunci: anti-wrinkle, ekstrak daun binahong, gel
Formulasi dan Evaluasi Lip cream Halal Menggunakan Ekstrak Tomat (Lycopersicon esculentum Mill) Sebagai Pewarna Alami ABDUL QOSIM
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p06

Abstract

Abstract— Lip cream is a semi-solid to liquid textured preparation that functions as a lip dye. Tomato plants can be used as natural dyes because they contain lycopene compounds which can give a yellow to red color. This study aims to determine whether tomato fruit extract can be formulated as a dye, determine the effect of adding tomato extract concentration and determine the halal critical point in the preparation of tomato fruit extract lip cream as a natural dye. The tomato fruit extraction method was carried out using UAE with methanol solvent. The resulting extract was then added to each formula with concentrations of F0 (0%), F1 (5%), F2 (10%) and F3 (15%). The organoleptic test results showed that all formulas had a semi-solid texture, smelled of roses and F0 was white, F1 was light orange, F2 was orange and F3 was brick red. All formulas comply with the homogeneity and pH test standards as indicated by the pH value range of 6.47 - 5.17. All formulas had good smearing power, adhesion of ?60 seconds and spreadability test values ??ranging from 5.90 to 5.63. The results of the ANOVA analysis on the pH and spreadability tests showed that the preparations had significant differences between the formulas. Evaluation of halal critical points on preparations does not have halal critical points in terms of materials and processing.
Uji Sifat Fisik dan Mikrobiologi Sediaan Lulur Krim yang Mengandung Serbuk Kopi serta Penentuan Aktivitas Antioksidannya Ni Kadek Warditiani
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p11

Abstract

In 2017 the Ministry of Industry noted Indonesia’s cosmetics industry in the country out numbered to 760 companies. Further,95% of the industry is dominated by small to medium industrial sector, for this reason, in order to comply with international standards and certification bodies, it is necessary to guarantee the product quality. One of the product tested was a cream scrub containing coffee. Coffee has various chemical compounds that have antioxidant activity which plays a very important role in preventing premature aging. The product quality testing carried out is physical testing, microbiology and also the determination of antioxidant activity. From the prior tests, it was found that the pH of the preparation was 5.73 for the type of oil-in-water emulsion, the spreadability was 5.34 and 6.29 cm. Adhesion 11.10 seconds. The preparation meets all microbiological requirements and has an IC50% of 69.09 ppm.
Kajian Literatur: Suplementasi Vitamin D Mengurangi Tingkat Keparahan serta Mencegah dan Mengobati COVID-19 Ayuningtyas Istiqomah; Wahyu Utami
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p02

Abstract

Supplementation can play a supporting role in COVID-19 patients, one of which is the provision of vitamin D supplementation. This study aims to discuss and examine the existing evidence regarding the effect of vitamin D supplementation in reducing severity and preventing/treating COVID-19. The method used is a literature study from various library sources that can be accessed using the PubMed and Google Scholar databases with the keywords [(“Vitamin D” OR “Vitamin D2” OR “Vitamin D3”) AND (“COVID-19” OR “Coronavirus Disease 2019” OR “SARS CoV 2”)]. Sixty-eight studies met the inclusion and exclusion criteria and are therefore included in this literature review. This study shows that the lower the level of vitamin D in the body, the higher the severity of COVID-19. In addition, the use of vitamin D supplementation has a positive effect on COVID-19 by reducing the risk of being infected with COVID-19, reducing the risk of death, and reducing the severity of COVID-19. This could be because vitamin D can enhance the innate immune system which is the body's first line of defense against pathogens and regulate the adaptive immune system to reduce cytokine storms, and has a potential protective role against acute respiratory distress syndrome by inhibiting the renin-angiotensin pathway. Therefore, vitamin D supplementation can be used as an additional treatment for COVID-19.
Analisis ABC Dalam Perencanaan Pengadaan Perbekalan Farmasi di Puskesmas Gamping 1 Yogyakarta Fiqri Zulpadly; Siti Nurhaliza Nadya Rahayu
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p07

Abstract

In carrying out the task of managing drugs and medical consumables, Primary Health Center has the responsibility to create a management that is done effectively and efficiently. One of them is managing a pharmaceutical inventory. In this study, ABC analysis on the planning of drugs and medical consumables procurement at Yogyakarta Gamping I Public Health Center was carried out with the aim of finding out the ABC grouping of its inventory based on its investment value and also the percentage proportion of each group. This research is a non-experimental study with descriptive analysis using quantitative data which was conducted retrospectively. Primary data was obtained through an interview with the pharmacist in charge at Yogyakarta Gamping I Primary Health Center. The source of the secondary data is the facility’s history of the procurement of drugs and medical consumables based on LPLPO from the period of Januari-Desember 2021. Results showed that among 137 items of drugs, only 0,73% of them were included in group A. Group B consists of 9 items and group C has 127 items. For medical consumables, 16,67% of the 54 items were categorized into group A. Group B has the percentage of 22,22% of items and group C with the remaining 61,11%. Keywords: abc analysis, procurement planning
Manfaat Terapi Tambahan Vitamin pada Pasien Nyeri Neuropati Diabetika Edenia Asisaratu; Rizaldy Taslim Pinzon; Esdras Ardi Pramudita
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p12

Abstract

Background: Painful Diabetic Neuropathy is one of the most common complications of Diabetes Mellitus, which becomes a burden that necessitates optimal treatment. Current treatment is symptomatic therapy with glycemic index control but it has yet to reach the best results. Supplementing with vitamins B and D has been shown to provide significant pain relief in previous studies. Methodology: This was a retrospective cohort study. A total of 107 subjects were sampled using consecutive sampling method and they were given either symptomatic therapy or symptomatic therapy plus vitamins for three months. The pain scale was measured using Neuropathic Pain Scale. Results: The subjects were compared in three comparison groups. Subjects who received symptomatic therapy plus vitamin had the greatest pain reduction (39,50±14,222) (p=0,000) in the first comparison group. Subjects who received symptomatic therapy plus vitamin B combination and vitamin D 1000 IU had the greatest pain reduction (53,00±6,749) (p=0,000) in the second comparison group. Subjects who received symptomatic therapy plus vitamin D 1000 IU had the greatest pain reduction (44,00±8,944) (p=0,088) in the third comparison group. Conclusions: Additional vitamin therapy resulted in a significantly greater pain reduction than symptomatic therapy alone. There was no significant difference in pain reduction between the vitamin D 400 IU addition and vitamin D 1000 IU addition. Keywords: painful diabetic neuropathy; pain intensity; vitamin B; vitamin D
Studi Potensi Ekstrak Etanol Biji Pepaya (Carica papaya L.) sebagai Pedikulisidal Semprot terhadap Kutu Pediculus humanus var. capitis Siti Jubaedah
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p03

Abstract

Pedikulosis kapitis merupakan infeksi kulit dan rambut kepala diakibatkan Pediculus humanus var. capitis yang saat ini masih sering terjadi. Pedikulisidal dari tumbuhan sudah banyak direkomendasikan sebagai pedikulisidal alternatif karena memiliki efek toksisitas pada manusia yang rendah. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanol biji pepaya terhadap kematian Pediculus humanus var. capitis. Penelitian menggunakan 5 ekor kutu kepala pada setiap kelompok perlakuan. Pengujian dilakukan dengan 5 perlakuan konsentrasi yaitu konsentrasi 5%, 10%, 15%, 20% dan 40%. Kontrol yang digunakan berupa kontrol positif yaitu permetrin 1% dan kontrol negatif yaitu aquabides. Dilakukan masing-masing tiga pengulangan. Hasil didapatkan konsentrasi 15%, 20%, 40%, dan kontrol positif memiliki presentase kematian yang tinggi yaitu 100%, konsentrasi 10% sebesar 80% kematian, kematian kutu terendah adalah konsentrasi 5% sebesar 60% dan kontrol negatif sebesar 0%. LC50 sebesar 9.685% sedangkan LC90 12.038%. Hasil uji fitokimia didapatkan bahwa esktrak etanol biji pepaya mengandung senyawa alkaloid, saponin, flavonoid dan tanin. Kesimpulan. Ekstrak biji pepaya memiliki efek pedikulisidal alami. Kata kunci : Carica papaya; Pedikulosis kapitis; Pedikulisidal
Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur Baha Udin; Renditya Ismiyati; Eva Kholifah; Endah Endah
Jurnal Farmasi Udayana Vol. 12, No 1, Tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i01.p08

Abstract

Indonesia is known to have various types of plants that can be used in medicine, one of which is Cassia alata. Cassia alata is a plant that has many properties so it can be used as herbal medicine or traditional medicine. One of the properties of the Cassia alata plant that has been widely studied is as an antifungal. Every part of the Cassia alata plant has secondary metabolites. Cassia alata leaves contain secondary metabolites of alkaloids, steroids, phenols, glycosides, terpenoids and flavonoids. Cassia alata flowers contain flavonoids, tannins and phenolic compounds and saponins. Cassia alata level contains alkaloids, flavonoids, glycosides, phytosterols, quinones, tannins and terpenoids. Compounds that have a role or antifungal activity in Cassia alata are phenolics, tannins, flavonoids, saponins, triterpenoids, steroids, and alkaloids.

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