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INDONESIA
Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana merupakan jurnal elektronik yang dikelola oleh jurusan Farmasi FMIPA Udayana. Jurnal ini yang merupakan media publikasi penelitian dan review article pada semua aspek ilmu farmasi yang bersifat inovatif , kreatif, original dan didasarkan pada scientific. Artikel yang dimuat dalam jurnal ini meliputi penemuan obat, sistem penghantaran obat serta pengembangan obat. Jurnal ini memuat bidang khusus di farmasi seperti kimia medisinal, farmakologi, farmakokinetika, farmakodinamika, analisis farmasi, sistem penghantaran obat, teknologi farmasi, bioteknolofi farmasi, obat herbal dan komponen aktif tanaman serta evaluasi klinik obat
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol. 12, No. 2, tahun 2023" : 7 Documents clear
REVIEW : ETNOBOTANI, TOKSISITAS, FITOKIMIA, DAN AKTIVITAS BIOLOGI DARI TUMBUHAN RENDA (Carissa carandas L) Fadhli, Haiyul; Difa, Faradini Ramsanjami; Frimayanti, Neni; Aryani, Fina
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p04

Abstract

Renda (Carissa carandas L.) is a plant in the Apocynaceae family with dichotomous branches and milky sap. The plant bears small, oval-shaped fruits that are green at first and turn reddish-purple as they ripen. This review aims to integrate the secondary metabolites and biological activities of Carissa carandas L while also providing the scientific evidence required for future research. Online and offline literature were used to review this article. Online literature is sourced from local and international journal publications from journal providers on the internet and from online literature in books and e-books. This article covers the ethnobotany, toxicity, secondary metabolite compounds, and biological activities reported through search engines such as Google Scholar, NCBI, PubMed, ScienceDirect, Research Gate, and Springer. Based on existing literature, Carissa carandas can help treat diabetes, hypertension, hepatoprotection, anticonvulsants, antimalarials, antioxidants, anthelmintics, diarrhea, and hyperlipidemia.
Aktivitas Penangkapan Radikal 2,2-difenil-1-pikril hidrazil Fraksi Terhidrolisis Asam Daun Duwet (Syzigium cumini L.) dan Daun Nangka (Artocarpus heterophyllus) Irianti, Tatang; Yasmin, Intan Farida; Astuti, Ratih Dwi; Purnomo, Hari
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p05

Abstract

Plants contain secondary metabolites, including flavonoids, whose molecules are still bound to glycosides or are not free molecules. Hydrolysis treatment to form free molecules in this study is expected to increase antioxidant activity. The antioxidant activity test used the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger test. The value of Inhibitory Concentration 50% (IC50) obtained will show the antioxidant activity of the acid hydrolyzed water fraction of duwet (Syzigium cumini L.) leaf and the insoluble hexane fraction of jackfruit (Artocarpus heterophyllus) leaf acid hydrolysis. The results of the hydrolysis of the water fraction of duwet leaves and the insoluble fraction of jackfruit leaf hexane were measured for their antioxidant activity by DPPH radical scavenging test using UV-Vis spectrophotometer. To identify compounds in the water fraction and insoluble hexane fraction that act as antioxidants, qualitative analysis was used TLC and determined total phenolic compounds and flavonoids. The highest antioxidant activity of duwet leaves was in the hydrolyzed water fraction for 3 hours, while in jackfruit leaves the insoluble hexane fraction was hydrolyzed for 3 hours. Thus, the hydrolysis carried out in this study was able to increase the antioxidant activity.
Review Artikel : Kandungan Fitokimia dan Potensi Urang Aring (Eclipta alba L.) Sebagai Bahan Baku Obat Untuk Mengatasi Kebotakan (Hair Loss) Angga Purnama, Dewa Julio; Dewi, Ni Luh Putu Putri
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p01

Abstract

Urang-Aring (Eclipta alba L.) belongs to the genus Eclipta from the Asteraceae family. This plant has been used for generations as traditional medicine and is known to have various pharmacological activities. In this review, we discuss the in vivo testing of several extracts from the urang-aring in mice, the phytochemical compounds contained and the pharmacological activity of the urang-aring extract. The results showed that the ethanol extract, petroleum ether and ethyl acetate fraction of the methanol extract from this plant were reported to have hair growth-promoting activity. Many research studies report that there are various types of phytochemical compounds such as triterpenes, saponins, flavonoids, thiophene, kumestan, coumarins and steroids in this plant. Among these compounds, wedelolactone and ?-sitosterol are considered to be responsible for their pharmacological activity in overcoming hair loss. Wedelolactone is known to have the activity of inhibiting the expression of TGF-?1 resulting in the elongation of hair follicles. Meanwhile, ?-sitosterol works as a 5?-reductase inhibitor so that it contributes to the treatment of androgenic alopecia.
KOMPARASI METODE PENINGKATAN LAJU DISOLUSI OBAT Rizqi, Syifa Maulidia; Chabib, Lutfi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p02

Abstract

The speed of dissolution becomes an important part in the manufacture of drugs, because it is related to drug absorption and bioavailability. In order to achieve a good dissolution rate, various methods with certain criteria are needed. This review article aims to find out various methods that can be used to increase the speed of drug dissolution, and can be used as a reference for choosing the most appropriate dissolution method. The article review method used is a narrative review type in the form of a description or explanation of methods for increasing dissolution as a comparison in terms of method selection. Journals were obtained through chrome, google scholar and researchgate using 16 journals. The results obtained are that there are several methods that can increase dissolution including amorphous co, the use of surfactants and so on. The conclusion obtained from this review of the article is that there are various methods of increasing dissolution such as the use of surfactants, co-crystals, amorphous cos and so on. Keywords: dissolution; method; narrative review
Isolasi, Identifikasi dan Aktivitas Antibakteri Fungi Endofit dari Daun Jarak Pagar (Jatropha curcas L.) terhadap Escherichia coli dan Salmonella typhi Cantika, Andi Besse Intan; Pakadang, Sesilia Rante; Salasa, Alfrida Monica
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p07

Abstract

Jarak Pagar (Jatropha curcas L.) merupakan salah satu tanaman yang mana bagian daunnya banyak digunakan untuk mengobati berbagai macam penyakit serta memiliki daya antibakteri. Penelitian ini bertujuan untuk memperoleh isolat fungi endofit dari Daun Jarak Pagar yang berpotensi dalam menghasilkan senyawa antibakteri. Daun Jarak Pagar dicuci bersih dengan air mengalir yang bersih kemudian disterilkan permukaannya dengan alkohol 75% dan NaOCl 5 %. Lalu diinokulasi pada media PDA selama 3-7 hari. Fungi endofit yang tumbuh dimurnikan dan diperoleh 5 isolat murni. Dimana isolat 1 (hijau) diduga fungi Aspergillus fumigatus, isolat 2 (hitam) diduga fungi Gliocladium sp., isolat 3 (jingga) diduga fungi Fusarium sp., isolat 4 (krem) diduga fungi Chaetomium sp., isolat 5 (putih) diduga fungi Geotrichum sp. Selanjutnya dilakukan uji aktivitas antibakteri isolat fungi endofit dengan cara dilihat dari pembentukan zona hambat disekitar koloni menggunakan metode difusi agar. Bakteri uji yang digunakan Escherichia coli dan Salmonella typhi. Diperoleh hasil pengamatan bahwa isolat 1 (hijau) merupakan satu dari lima isolat yang ditemukan pada Daun Jarak Pagar tidak berpotensi dalam menghambat bakteri Escherichia coli dan dua isolat yaitu isolat 1 (hijau) dan isolat 3 (jingga) yang ditemukan pada Daun Jarak Pagar tidak berpotensi dalam menghambat bakteri Salmonella typhi.
Uji Aktivitas SOD (Superoxide Dismutase) Bakteri Limbah Cair Tahu dengan Metode WST-1 (Water Soluble Tetrazolium Salt-1) dan Identifikasi Molekuler Bakteri Menggunakan PCR 16S rDNA Pinesti, Arum; Indrayati, Ana; Cahyo, Lukito Mindi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p03

Abstract

Abstrak-Superoksida dismutase (SOD) merupakan enzim antioksidan endogen yang dapat dihasilkan oleh beberapa mikroorganisme seperti bakteri yang digunakan untuk menetralisir radikal bebas. Tujuan penelitian ini adalah isolasi dan identifikasi bakteri penghasil SOD dari limbah cair tahu, menguji aktivitas SOD dan identifikasi molekuler dengan PCR 16S rDNA bakteri yang memiliki aktivitas SOD tertinggi. Tahapan penelitian meliputi: isolasi bakteri dari limbah cair tahu menggunakan media NA. Lima isolat bakteri dipilih dan diidentifikasi berdasarkan perbedaan morfologi. Tahap selanjutnya ekstraksi SOD, penetapan kadar protein dengan BCA Assay dan uji aktivitas menggunakan WST-1 Assay Kit. Bakteri dengan aktivitas SOD tertinggi didentifikasi molekuler menggunakan PCR 16S rDNA. Lima isolat bakteri berhasil diisolasi. LCT 1, 2 dan 3 termasuk Gram positif sedangkan LCT 4 dan 5 termasuk Gram negatif. Ekstraksi enzim dilakukan pada kelima isolat lalu dipresipitasi dengan amonium sulfat 80%. Isolat LCT 5 memiliki aktivitas SOD tertinggi yaitu 87,90%. Hasil identifikasi PCR 16S rDNA adalah Pseudomonas aeruginosa strain HSS-6.
Potensi Liposom Sebagai Nanocarrier Antituberkulosis Pada Sediaan Inhalasi Parameswari, Natashya; ., Sriwidodo
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p08

Abstract

Tuberculosis (TB) is a respiratory tract infection that remains a global health problem to this day. There were more than 10, 6 million TB cases with approximately 1,5 million deaths in 2021. The oral therapy regimen consisting of isoniazid (INH), ethambutol (EMB), pyrazinamide (PZA) dan rifampicin (RIF), despite having a successful treatment rate up to 95% still faces limitation contributing to low treatment compliance and the development of drug-resistance Mtb strains. Strategy to overcome these limitations is to deliver drugs by inhalation as aerosols to the lung, the primary site of Mtb infection. Liposome-based nanocarriers have been proven effective in improving drug bioavailability and reducing toxicity. Therefore, this article review aims to explore the potential nanocarriers in pulmonary drug delivery systems

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