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Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
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Articles 11 Documents
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Search results for , issue "Vol. 45 No. 4 (2012): December 2012" : 11 Documents clear
The role of Actinobacillus actinomycetemcomitans fimbrial adhesin on MMP-8 activity in aggressive periodontitis pathogenesis Rini Devijanti Ridwan
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 4 (2012): December 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.496 KB) | DOI: 10.20473/j.djmkg.v45.i4.p181-186

Abstract

Background: Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) is Gram negative and a major bacterial agent associated with aggressive periodontitis in young adult, this bacteria was an important factor in pathogenesis of aggressive periodontitis. A. actinomycetemcomitans possesses fimbriae with an adhesin protein that was the first bacterial molecules to make physical contact with host. Purpose: The objective of this research was to analyzed the influence of A. actinomycetemcomitans fimbrial adhesin protein induction on MMP-8 activity. Methods: The research was an experimental laboratory study, the step in this study were isolation and identification A. actinomycetemcomitans, characterize A. actinomycetemcomitans adhesin and study the role of A. actinomycetemcomitans adhesin in Wistar rats. Results: The result of this research on the role of adhesin in Wistar rats after analysis with Analysis of Variance (ANOVA) showed significant differences in the control group with group induction with A. actinomycetemcomitans, A. actinomycetemcomitans plus adhesin and adhesin. MMP-8 activity increased with induction A. actinomycetemcomitans and 24 kDa A. actinomycetemcomitans adhesin. This fimbrial adhesin protein showed that A. actinomycetemcomitans has the ability to adhesion, colonization and invasion for host in aggressive periodontitis pathogenesis. Conclusion: A. actinomycetemcomitans fimbrial adhesin protein induction increasing MMP-8 activity for aggressive periodontitis pathogenesis.Latar belakang: A. actinomycetemcomitans merupakan salah satu bakteri Gram negatif yang terkait dengan periodontitis agresif yang menyerang penderita usia muda dan merupakan faktor penting dalam patogenesis periodontitis agresif. A. actimycetemcomitans mempunyai fimbriae dengan protein adhesin yang merupakan molekul pertama dari bakteri untuk melakukan kontak fisik dengan host. Tujuan: Tujuan penelitian ini adalah menganalisis pengaruh induksi adhesin A. actinomycetemcomitans terhadap aktivitas MMP-8. Metode: Penelitian ini merupakan studi eksperimental laboratori, langkah dari penelitian ini adalah isolasi dan identifikasi A. dan identifikasi A. actinomycetemcomitans, isolasi dan karakterisasi adhesin A. actinomycetemcomitans dan uji peran adhesin A. actinomycetemcomitans di tikus Wistar. Hasil: Hasil analisis menunjukkan adanya aktivitas MMP-8 yang meningkat bermakna di kelompok kontrol dibandingkan dengan kelompok dengan induksi A. actinomycetemcomitans, A. actinomycetemcomitans + adhesin dan adhesin. Hal ini menunjukkan bahwa A. actinomycetemcomitans berkemampuan melakukan adesi, kolonisasi dan invasi pada host dalam patogenesis periodontitis agresif. Kesimpulan: Induksi protein adhesin A. actinomycetemcomitans dengan berat molekul 24 kDa meningkatkan aktivitas MMP-8 pada patogenesis periodontitis agresif.

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