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INDONESIA
Science and Technology Indonesia
Published by Universitas Sriwijaya
ISSN : 25804405     EISSN : 25804391     DOI : -
Core Subject : Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics
An international Peer-review journal in the field of science and technology published by The Indonesian Science and Technology Society. Science and Technology Indonesia is a member of Crossref with DOI prefix number: 10.26554/sti. Science and Technology Indonesia publishes quarterly (January, April, July, October). Science and Technology Indonesia is an international scholarly journal on the field of science and technology aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that covers a typical subject of natural science and technology such as: > Chemistry > Biology > Physics > Marine Science > Pharmacy > Chemical Engineering > Environmental Science and Engineering > Computational Engineering > Biotechnology Journal Commencement: October 2016
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Articles 21 Documents
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Search results for , issue "Vol. 8 No. 2 (2023): April" : 21 Documents clear
Formulation and Evaluation of Azithromycin Dihydrate Solid Dispersion with Esther of Polyethylene Glycol-6000 and Stearic Acid Using A Co-Grinding Technique Mardiyanto; Budi Untari; Ady Mara; Nauval Hady Prasetyo
Science and Technology Indonesia Vol. 8 No. 2 (2023): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.2.312-320

Abstract

Azithromycin is a narrow-spectrum bacterial growth inhibitory antibiotic derived from macrolides with low dissolution in water. Several methods have been carried out to increase the dissolution of medicinal substances, one of which is solid dispersion. Solid dispersions are mixtures consisting of one or more active substances in an inert carrier. The purpose of this study was to determine the effect of formatting solid dispersions with PEG 6000 polymer and stearic acid on increasing the dissolution rate of azithromycin. The method of formatting solid dispersions uses the co-grinding method. Solid dispersion of azithromycin was prepared in four formulas with variations in the amount of PEG 6000. Tests carried out on solid dispersion samples of azithromycin were XRD, FTIR, SEM, solubility tests, and dissolution tests. Test results on azithromycin solid dispersions prepared by co-grinding showed that there was an effect of the amount of PEG 6000 on decreasing the intensity of azithromycin crystals, there was no chemical interaction between azithromycin and the carrier, differences in the morphology of pure azithromycin powder and solid dispersions, and an increase in the dissolution of solid dispersions in medium SIF.

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