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All Journal Jurnal Kesehatan Bakti Tunas Husada Journal of Pharmacopolium
Dzakwan, Muhammad
Fakultas Farmasi Universitas Setia Budi
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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MODIFICATION OF PHYSICOCHEMICAL PROPERTIES FISETIN THROUG SPHERICAL CRYSTAL TECHNIQUES Dzakwan, Muhammad
Journal of Pharmacopolium Vol 2, No 1 (2019)
Publisher : P3M STIKes Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.765 KB)

Abstract

Fisetin is a natural antioxidant that has shown to posses antioxidant and anti-inflammatory. However, the poor solubility leads to poor bioavailability and limits its development. Fisetin spherical agglomerates were prepared with ethanol, water, chloroform and polyvinylpyrrolidone (PVP)  as solvent, anti-solvent, bridging liquid and polymer, respectively. The main objective of this research to overcome the low fisetin solubility, micromiretic properties and in vitro dissolution. It was prepared using spherical agglomeration method, organic solvent and polymer. Characterization is carried out on morphology particle, drug loading efficiency, solubility and in vitro disolution. XRD studies showed a decrease in crystallinity in agglomerates. The crystals exhibited significantly improved micromeritic properties compared to pure drug. The loading efficiency was in the range of 98.25 ± 1,20 %. The aqueous solubility and dissolution rate of the drug from crystals was significantly increased, 4,45 mg/ml ± 0,31 dan 98,75%, respectively. The SEM studies showed that the crystal posseses a good spherical shape with smooth and regular surface. Conclusion, fisetin was successfully prepared by spherical agglomeration method, with the polyvinylpyrrolidone 5% as polymer,  ethanol as good solvent, water as antisolvent and choloform as bridging solvent.. Fisetin increased its solubility and in vitro disolution significantly after spherical agglomeration Keywords: fisetin, spherical crystallization, solubility, in vitro dissolution , micromeritic properties.
KINETIC SOLUBILITY OF MEBENDAZOLE NANOCRYSTAL Dzakwan, Muhammad
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 18, No 1 (2018)
Publisher : STIKes BTH Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.333 KB) | DOI: 10.36465/jkbth.v18i1.299

Abstract

MBZ nanosuspensions were produced by high pressure homogenization and transformed into dry powder by lyophilization. MBZ nanocrystals were intensively evaluated regarding their physicochemical properties with respect to particle size analyses, crystallinity and kinetic solubility. The particle size was determined by photon correlation spectroscopy (PCS. DSC and X-ray diffraction were used to study the crystalline state of MBZ nanocrystals. In a period of 1 week, the kinetic solubility was determined using a shaker water bath at 37O C. DSC and X-ray diffraction analyses showed that lyophilized MBZ nanocrystals prepared by high pressure homogenization remained in crystalline state. Lyophilized MBZ nanocrystals could be re-dispersed completely in water and the kinetic solubility in water increased 9 fold, from 60,57 ηg/ml to 598 ηg/ml
INOVASI SEDIAAN ORAL FISETIN DENGAN TEKNOLOGI SMART EDIBLE PAPER Dzakwan, Muhammad
Journal of Pharmacopolium Vol 2, No 3 (2019)
Publisher : P3M STIKes Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jop.v2i3.536

Abstract

Fisetin is a flavonoid compound has natural antioxidant, anti-inflammatory and anticancer activities. It hasvery low bioavailability and the provision of fisetin in the oral dosage form is very limited. Research has beencarried out to develop and increase solubility and dissolution of fisetin. It was further developed into a solidoral dosage form of tablets with an edible paper matrix. This study that to develop fisetin into tablet dosageform with an edible paper matrix, determine the physical quality of tablets and drug release in vitro. Fisetin wasdissolved in a suitable solvent and then poured over an edible paper matrix, dried and cut in 1x1 cm size. Papercuttings are printed directly with various compressive strengths of 2, 4 and 6 tons. Tablet physical quality testsinclude hardness, disintegration time, friability, weight uniformity, and drug content. Furthermore, dissolutionwas tested and the best formula was chosen. The results of this research show that fisetin has the greatestsolubility with DMSO solvent. The edible paper matrix weight is 1000 mg and a tablet weight is 500 mg.Formula I with a compressive strength of 2 tons is the best formula and meets the physical quality testrequirements of the tablet. The release of formula I (FI) drug was superior (95.20%) and significantly higher(p<0,05) compared to formula II and III.
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