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Boima Situmeang
Jurusan Kimia, Sekolah Tinggi Analis Kimia Cilegon, Banten
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering

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FORMULASI EKSTRAK DAUN KITOLOD (HIPOBROMA LONGIFLORA) DALAM SEDIAAN OBAT KUMUR ALAMI TERHADAP BAKTERI STREPTOCOCCUS MUTANS Boima Situmeang; Dzulhijar; Juliandoz; Ahmad Fajar Muzakir; Agus Malik Ibrahim; Nani Yulianti; Nurhayati Bialangi; Weny JA Musa
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 7 No. 2 (2025): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v7i2.5802

Abstract

The kitolod plant (Hippobroma longiflora) has been demonstrated to possess antibacterial activity against Streptococcus mutans, the bacterium responsible for the development of dental caries. The objective of this study was to formulate a mouthwash preparation using kitolod leaf extract. The extract was formulated into three distinct formulations. The mouthwash was evaluated for its pH, viscosity, stability, and antibacterial activity. The antibacterial evaluation was executed in accordance with the Kirby-Bauer method. The positive control utilized in this study was 0.2% chlorhexidine. The pH test results indicated that all three formulations had a pH of 6. The viscosity test demonstrated that all formulations had a viscosity of 0.99, which is close to that of water. The antibacterial evaluation against S. mutans indicated that formulation 2 demonstrated the most pronounced antibacterial activity, exhibiting an inhibition zone measuring 3.81 mm. All three formulations exhibited stability at ambient temperature. In light of the findings from this study, it can be posited that formulation 2 possesses the potential to serve as a natural mouthwash.
PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN COCOK BEBEK (Kalanchoe pinnata) DENGAN METODE DPPH DAN ABTS Boima Situmeang; Weny JA Musa; Nurhayati Bialangi; Nani Yulianti
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7746

Abstract

Kalanchoe pinnata leaves are known as a medicinal plant containing secondary metabolites with potential antioxidant activity. This study aimed to compare the antioxidant activity of the ethanol extract of Kalanchoe pinnata leaves using DPPH and ABTS methods. Extraction was carried out by maceration using ethanol as a solvent from 50 g of dried leaf simplicia, yielding 7.2 g of thick extract with a yield of 14.4%. Antioxidant activity was evaluated at concentrations of 20, 40, 60, 80, and 100 ppm. The results showed that the percentage of inhibition increased with increasing extract concentration in both methods. In the DPPH method, the highest inhibition value was 51.1605% at 100 ppm, while in the ABTS method it was 47.7203%. The IC₅₀ values obtained were 93.54 ppm for the DPPH method and 103.01 ppm for the ABTS method. Based on these values, the antioxidant activity of the ethanol extract of Kalanchoe pinnata leaves was categorized as strong in the DPPH method and moderate in the ABTS method. In conclusion, the DPPH method showed higher antioxidant activity compared to the ABTS method. The ethanol extract of Kalanchoe pinnata leaves has the potential to be developed as a natural antioxidant source in pharmaceutical and functional food applications.
Co-Authors Agus Malik Ibrahim Ahmad Fajar Muzakir Dzulhijar Juliandoz Nani Yulianti Nurhayati Bialangi Nurhayati Bialangi Weny JA Musa Weny JA Musa