Human resources (HR) have a significant role in every activity in an institution, including government institutions. Human resources (HR) must be able to be managed or managed well in accordance with their function so that these human resources (HR) can play a role in accordance with their duties and functions in the institution they work in. This research aims to analyze the influence of leadership and work environment on employee performance by mediating employee job satisfaction in the General Section of the Raja Ampat Regency Regional Secretariat. The population used was all employees of the General Section of the Raja Ampat Regional Secretariat, namely 44 employees. The number of samples used was 44 employees with a sampling technique using a saturation technique. The data analysis used in this research is inferential analysis using SEM-PLS. The results of this research show Leadership has a positive and significant effect on employee performance. Leadership has a positive and significant effect on job satisfaction. The work environment has a positive and significant effect on employee performance. Work Environment has a positive but not significant effect on Job Satisfaction. Job satisfaction has a positive and significant effect on employee performance. Leadership has a positive and significant effect on employee performance through Job satisfaction. Job satisfaction partially mediates (partial mediation) between leadership and employee performance. The work environment has a positive but not significant effect on employee performance Job satisfaction. Job satisfaction is not able to mediate (Unmediated) between Work environment on Performance Employee.