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All Journal Tsaqofah: Jurnal Penelitian Guru Indonesia
Firna, Bismi Rahma
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Education

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Tinjauan Literatur tentang Faktor Risiko, Pencegahan, dan Penanganan Palatoskizis (Celah Langit-Langit) Firna, Bismi Rahma; Atifah, Yusni
TSAQOFAH Vol 5 No 4 (2025): JULI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i4.6299

Abstract

Palatoschisis is a congenital craniofacial anomaly with significant clinical and social implications, particularly in developing countries where prevention and management efforts continue to face numerous challenges. This study aims to systematically review the scientific literature on risk factors, early detection methods, and management approaches for palatoschisis. A systematic literature review was conducted based on ten scholarly articles published in the past ten years, sourced from PubMed, ScienceDirect, and Google Scholar. Inclusion criteria consisted of articles in English or Indonesian that addressed the etiology, diagnosis, and treatment of palatoschisis. Thematic analysis was applied to categorize findings into key thematic areas. The review identified major risk factors including genetic mutations (e.g., IRF6 and MSX1), micronutrient deficiencies (folate and vitamin A), and exposure to teratogenic substances such as tobacco and pesticides. Early detection using 3D ultrasound was found to be effective for prenatal identification. Optimal management requires a multidisciplinary approach involving surgical intervention, speech therapy, and psychosocial support for both the child and their family. The study concludes by underscoring the importance of cross-sector collaboration in promoting comprehensive prevention and management strategies, as well as the need to ensure equitable access to healthcare services and public education to improve the quality of life for individuals affected by palatoschisis.
Pemeriksaan Histopatologi Jaringan Payudara pada Pasien (Carcinoma Mammae) dengan Metode Haematoxylin dan Eosin di Instalasi Patologi Anatomi Firna, Bismi Rahma
TSAQOFAH Vol 5 No 4 (2025): JULI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i4.6300

Abstract

Histopathological examination plays a crucial role in cancer diagnosis, including carcinoma mammae, yet systematic documentation of technical procedures remains limited, particularly in educational laboratory settings. This study aims to provide a detailed description of the histopathological examination stages of breast tissue using the Hematoxylin and Eosin (HE) staining method in patients with carcinoma mammae. The research employed a descriptive approach conducted at an anatomical pathology laboratory from January to February 2025. The study object consisted of breast tissue specimens from cancer patients, processed through stages including fixation, macroscopic sectioning, dehydration, clearing, impregnation, embedding, microtome sectioning, HE staining, mounting, and microscopic evaluation. Key instruments included a rotary microtome, tissue processor, and autostainer, while materials used comprised alcohol, distilled water, xylol, hematoxylin, and eosin. Results indicate that each procedural step significantly contributes to tissue integrity and the quality of microscopic interpretation. HE staining proved effective in revealing cancer cell morphology, with hematoxylin staining cell nuclei bluish-purple and eosin staining cytoplasm pink. The histological features showed hallmark characteristics of malignant tumor cells, such as nuclear pleomorphism, atypical mitoses, and lymphovascular invasion. In conclusion, the HE staining method enables clear and accurate histological visualization to support the diagnosis of carcinoma mammae.
Co-Authors Atifah, Yusni