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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset
Danjuma, Janya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Nursing Public Health Social Sciences

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Determination of the Hypoglycaemic Effect of the Ethanol Stem Bark Extract of Vitellaria paradoxa on Hyperglycemic Wistar Rats Ekpo, Fidelis Okii; Mamman, Emmanuel; Yakubu, Ojochenemi Ejeh; Danjuma, Janya
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3469

Abstract

This study investigates the hypoglycaemic effects of the ethanol stembark extract of Vitellaria paradoxa on hyperglycemic rats. It also investigates the phytochemical content of ethanol stem bark extract of Vitellaria paradoxa using the method of Soforh. The result shows that the ethano| stem/bark of the plant contains Tannins 3.92/mg/100g, Alkaloid 7.12/mg/100g, Flavonoids 1.03/gm/100g, phenolics 12.72/mg/100g, Glycosides 4.13/gm/100g, saponins 2.15/mg/100g respectively. The hypoglycemic properties of ethanol stem bark extract of Vitellaria paradoxa were investigated using Fifteen albino Wister rats weighing between 200g to 230g were induced with alloxan monohydrate to make them diabetic. The rats were divided into five groups of three rats. The first group were not induced, tagged normal. The second groups were induced sstandard drug glibenclamide throughout the study period. The fourth groups were induced and treated with 250/mg/kg body weight of the ethanol stem/bar extract of Vitellaria paradoxa throughout the study period. The fifth groups were induced and treated with 500/mg/kg body weight of the extract. The fasting blood glucose level of the rats were taken every three days’ interval for 21 days. At the end of 21 days, the rats treated with 250/mg/kg body weight which started with elevated blood glucose level after induction of 207/mg/dl reduces to 124/mg/dl, similarly the treated with 500/mg/kg body weight of the extract with initial elevated blood glucose level after the induction with diabetic of 221/mg/dl got reduced to 145/me/dl. This indicates that ethanol bark tract of Vitellaria paradoxa showed hypoglycemic properties.
The Comparative Suitability of Different Solvents Used in the Fractionation of Methanol Leaf Extract of Persea americana Mill: An in Vitro Studies Yakubu, Ojochenemi E.; Otitoju, Olawale; Danjuma, Janya; Maianguwa, dulrashid Dauda; Umaru, Isaac John; Oladele, Gloria Omonefe
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3664

Abstract

This research investigated the suitability of various solvents used in the fractionation of methanol leaf extract of P. americana to ascertain the flavonoid, vitamin and amino acid profile of the fractions. It has been demonstrated that a number of Persea americana plant components contain different phytochemicals associated with important biological function. Fresh leaves of P. americana were harvested from Baissa in Taraba State. The plant materials were air dried under shade at ambient temperature. The dried plant materials were pulverized to fine powder using mortar and pestle. The pulverized plant material was soaked in methanol for 72 hours for extraction. The extract was filtered using clean filter cloth and filter paper under reduced pressure. The filtrate was evaporated in in rotary evaporator and water bath to obtain the required concentrate. The extract was used to perform fractionation using separation funnel and solvents of different polarity such n-hexane, methanol and ethanol. Each of the fractions was used to analyze for flavonoid, vitamin and amino acid profile using HPLC. The result reveals that quercetin is present in each of the fractions. Caffeic acid phenyl ether was detected in diluted ethanol fraction, coumaric acid was identified in diluted n-hexane fraction, caffeic acid was identified in methanol fraction chlorogenic acid detected in n-hexane fraction. Vitamin K was identified in all the fractions, Vitamin B1 was identified in diluted ethanol fraction and n-hexane fraction while vitamin B9 was detected in diluted n-hexane fraction and n-hexane fraction. Vitamins B2 and B6 were identified in methanol fraction and diluted ethanol fraction respectively. The diluted ethanol fraction was seen to contain 8 different amino acids followed by the methanol fraction with 6, then the diluted n-hexane fraction with 3 and the n-hexane fraction with 2. This reveals that for isolation of amino acids, the ethanol fraction may be more suitable considering that the highest number of amino acids were found in it.
Co-Authors Abu, Michael S. Ekpo, Fidelis Okii Iruka, Assumpta Jankada, Patience Audu Maianguwa, dulrashid Dauda Mamman, Emmanuel Oladele, Gloria Omonefe Otitoju, Olawale Umaru, Isaac John Yakubu, Ojochenemi E. Yakubu, Ojochenemi Ejeh