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Mitigating Alcohol-Induced Liver Enzyme Alterations in Wistar Rats Through Forced Swimming Exercise I, Abdul-Kareem Y.; U, Chidiebere; G, Yilgwan; M, Usman Y.; Z, Galam N.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3703

This study investigates the impact of forced swimming exercise on alcohol-induced alterations in hepatic enzyme biomarkers in Wistar rats (mean weight 150-200g). Twenty Wistar rats were randomly divided into four groups of five rats each: a normal control group, an exercise-only group, an alcohol-only group, and an exercise plus alcohol group. The control group received 0.9% normal saline 5 days a week for 12 weeks. The exercise group underwent forced swimming for 5 minutes a day, 5 days a week, for 12 weeks. The alcohol group received 20% ethanol orally at a dose of 2.0g/kg body weight. The combined exercise and alcohol group followed the same protocols as the exercise and alcohol groups. At the end of the 12-week period, all animals were euthanized, and blood samples were collected for analysis of hepatic enzyme biomarkers, including ALT, AST, and GGT, using an automated serum biochemistry analyzer. Results showed significant elevation of hepatic enzyme biomarkers in the alcohol-only group, while the normal control, exercise-only, and exercise plus alcohol groups exhibited decreased enzyme levels. These findings indicate that exercise mitigates alcohol-induced liver enzyme alterations in adult male Wistar rats. The study suggests that exercise training may be effective in alleviating liver damage from chronic alcohol consumption and could potentially prevent liver failure and hepatocellular carcinoma.

Swimming Away the Damage: Exercise Combats Alcohol-Induced Liver Stress in Wistar Rats I, Abdul-kareem Y.; C, Uchendu; G, Yilgwan; P, Nyango; M, Usman Y.; Z, Galam N.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 2 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i2.3795

This study investigated the impact of forced swimming exercise on alcohol-induced oxidative stress biomarkers and liver histo-architecture in Wistar rats (mean weight 150 to 200g). The rats were randomly assigned to four groups of five: normal control, exercise only, alcohol only, and exercise plus alcohol. The control group received 0.9% saline for 5 days a week over 12 weeks. The exercise group underwent forced swimming for 5 minutes daily, 5 days a week, for 12 weeks. The alcohol group was given 20% ethanol orally at a dose of 2.0 g/kg body weight. The exercise plus alcohol group received both treatments as described for the exercise and alcohol groups. At the end of the exposure period, all animals were euthanized, and blood and liver tissue samples were collected for analysis of oxidative stress biomarkers (SOD, CAT, GPx, and MDA) and liver histo-architecture. The ethanol-exposed group showed significantly elevated oxidative stress markers, whereas the normal, exercise, and exercise plus alcohol groups exhibited decreased levels. Marked hepatocellular necrosis and perivascular inflammation were observed in the ethanol group, along with moderate central vein congestion. In contrast, the normal and exercise groups displayed normal hepatocellular architecture with no inflammatory cells and clear central veins. The exercise plus alcohol group showed largely normal liver architecture, with very mild necrotic cells, no inflammatory cells, and a clearly visible central vein, indicating that exercise mitigated alcohol-induced liver changes in adult male Wistar rats. These findings suggest that exercise training can alleviate oxidative stress and prevent liver architecture damage following chronic alcohol consumption, potentially helping to prevent liver failure and hepatocellular carcinoma.

Mitigating Alcohol-Induced Liver Enzyme Alterations in Wistar Rats Through Forced Swimming Exercise I, Abdul-Kareem Y.; U, Chidiebere; G, Yilgwan; M, Usman Y.; Z, Galam N.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3703

This study investigates the impact of forced swimming exercise on alcohol-induced alterations in hepatic enzyme biomarkers in Wistar rats (mean weight 150-200g). Twenty Wistar rats were randomly divided into four groups of five rats each: a normal control group, an exercise-only group, an alcohol-only group, and an exercise plus alcohol group. The control group received 0.9% normal saline 5 days a week for 12 weeks. The exercise group underwent forced swimming for 5 minutes a day, 5 days a week, for 12 weeks. The alcohol group received 20% ethanol orally at a dose of 2.0g/kg body weight. The combined exercise and alcohol group followed the same protocols as the exercise and alcohol groups. At the end of the 12-week period, all animals were euthanized, and blood samples were collected for analysis of hepatic enzyme biomarkers, including ALT, AST, and GGT, using an automated serum biochemistry analyzer. Results showed significant elevation of hepatic enzyme biomarkers in the alcohol-only group, while the normal control, exercise-only, and exercise plus alcohol groups exhibited decreased enzyme levels. These findings indicate that exercise mitigates alcohol-induced liver enzyme alterations in adult male Wistar rats. The study suggests that exercise training may be effective in alleviating liver damage from chronic alcohol consumption and could potentially prevent liver failure and hepatocellular carcinoma.

Swimming Away the Damage: Exercise Combats Alcohol-Induced Liver Stress in Wistar Rats I, Abdul-kareem Y.; C, Uchendu; G, Yilgwan; P, Nyango; M, Usman Y.; Z, Galam N.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 2 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i2.3795

This study investigated the impact of forced swimming exercise on alcohol-induced oxidative stress biomarkers and liver histo-architecture in Wistar rats (mean weight 150 to 200g). The rats were randomly assigned to four groups of five: normal control, exercise only, alcohol only, and exercise plus alcohol. The control group received 0.9% saline for 5 days a week over 12 weeks. The exercise group underwent forced swimming for 5 minutes daily, 5 days a week, for 12 weeks. The alcohol group was given 20% ethanol orally at a dose of 2.0 g/kg body weight. The exercise plus alcohol group received both treatments as described for the exercise and alcohol groups. At the end of the exposure period, all animals were euthanized, and blood and liver tissue samples were collected for analysis of oxidative stress biomarkers (SOD, CAT, GPx, and MDA) and liver histo-architecture. The ethanol-exposed group showed significantly elevated oxidative stress markers, whereas the normal, exercise, and exercise plus alcohol groups exhibited decreased levels. Marked hepatocellular necrosis and perivascular inflammation were observed in the ethanol group, along with moderate central vein congestion. In contrast, the normal and exercise groups displayed normal hepatocellular architecture with no inflammatory cells and clear central veins. The exercise plus alcohol group showed largely normal liver architecture, with very mild necrotic cells, no inflammatory cells, and a clearly visible central vein, indicating that exercise mitigated alcohol-induced liver changes in adult male Wistar rats. These findings suggest that exercise training can alleviate oxidative stress and prevent liver architecture damage following chronic alcohol consumption, potentially helping to prevent liver failure and hepatocellular carcinoma.

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