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All Journal African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset
K, Dasofunjo
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Nursing Public Health

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Anabolic, Androgenic and Anti-Cholesterolemic Effect of Kigelia africana Leaf Extract on Some Male Wistar Rats K, Dasofunjo
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3729

Abstract

Male erectile dysfunction (ED) refers to incompetency in reaching and retaining adequate penile tumescence for sexual intercourse, possibly due to hormonal imbalance or its inverse relationship with age. Over 152 million men globally suffer from ED and by 2025; the number of affected individuals is anticipated to be around 322 million. In this research work, the effect of petroleum ether extract of Kigelia africana on lipid profile and reproductive hormones of Wistar rats was examined. The leaf of K,africana was collected, air-dried , pulverized and extracted using 1200ml of 70% petroleum ether for 72 hours. This was then concentrated and stored in a refrigerator at 4°C. Twenty-one (21) Wistar male rats were used for this research. The animals were acclimatized for seven (7) days. Treatment was carried out as follows: group 1 (normal control) received only the vehicle (Normal saline) orally, while groups 2 and 3 received an extract of (200 and 400 mg/kg b.wt/day respectively for 2 successive weeks. The rats were sacrificed and the blood was collected by cardiac puncture for the analysis of lipid profile and reproductive hormones. The result revealed that the extract produced a significant increase (p<0.05) in serum testosterone, follicle-stimulating hormone, luteinizing hormone, TAG and HDL but a significant (p<0.05) decrease in serum total–cholesterol and LDL respectively when compared with normal control. It was speculated that the extract may possess anabolic, androgenic and anti/ hypocholesterolaemic effect which might reduce the risk of predisposition to both cardiovascular and erectile dysfunctions possibly due the presence of phytoandrogens and phytonutrients like alkaloids and flavonoids.
Effect of Ethanol Extract of Terminalia catappa on Serum Reproductive Hormones in Poloxaimer Induced Hypercholesterolemic Female Wistar Rats K, Dasofunjo; C, Nyeche S.; O, Ogar B.; O, Emuru E.; O, Owu D.; O, Ugbada M.; B, Odu F.; N, Ogar U.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3730

Abstract

This research work was carried out to access the effect of ethanol extract of Terminalia catappa, on sexual hormones in poloxamer induced hypercholesterolemia in Wistar rats. Thirty- five (35) Wistar female rats were allowed to acclimatize for a period of 7 days, in a well-ventilated room at room temperature and relative humidity of 29°C and 70% respectively with 12 hours natural light-dark cycle. They were allowed food and water ad libitum. Good hygiene was maintained by daily cleaning and removal of faeces and spills from their cages. The rats were randomly divided into 5 groups of 7 rats each. Group A: was fed with normal chow and distilled water (NC). Group B: was induced with 1.0g/kg dose of P-407 without treatment (HC). Group C: was induced with 1.0g/kg dose of P-407 and treated with atorvastatin (ATV) at 20mg/kg body weight, Group D: was induced with 1.0g/kg dose of P-407 and treated with leaves extract (HLE) at 100mg/kg body weight, Group E: was induced with 1.0g/kg dose of P-407 and treated with leaf extract (HLE) at 200mg/kg body weight/ day for 14days .The dose regimens were administered once daily for the period of the study. The rats were monitored for clinical signs and death. The result reveals that there was a significant (P<0.05) increase in serum oestrogen, progesterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) when compared with the normal, standard and hyperlipidemic control. Contrastingly, there was a significant decrease (P< 0.05) in serum testosterone and prolactin (PRL) when compared to the normal and standard control. It can be inferred from this present research work that the extract may stimulate or regulate ovulation or promote sexual health and or drive possibly due to the presence of phytonutrient or phytoandrogens.
Anabolic, Androgenic and Anti-Cholesterolemic Effect of Kigelia africana Leaf Extract on Some Male Wistar Rats K, Dasofunjo
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3729

Abstract

Male erectile dysfunction (ED) refers to incompetency in reaching and retaining adequate penile tumescence for sexual intercourse, possibly due to hormonal imbalance or its inverse relationship with age. Over 152 million men globally suffer from ED and by 2025; the number of affected individuals is anticipated to be around 322 million. In this research work, the effect of petroleum ether extract of Kigelia africana on lipid profile and reproductive hormones of Wistar rats was examined. The leaf of K,africana was collected, air-dried , pulverized and extracted using 1200ml of 70% petroleum ether for 72 hours. This was then concentrated and stored in a refrigerator at 4°C. Twenty-one (21) Wistar male rats were used for this research. The animals were acclimatized for seven (7) days. Treatment was carried out as follows: group 1 (normal control) received only the vehicle (Normal saline) orally, while groups 2 and 3 received an extract of (200 and 400 mg/kg b.wt/day respectively for 2 successive weeks. The rats were sacrificed and the blood was collected by cardiac puncture for the analysis of lipid profile and reproductive hormones. The result revealed that the extract produced a significant increase (p<0.05) in serum testosterone, follicle-stimulating hormone, luteinizing hormone, TAG and HDL but a significant (p<0.05) decrease in serum total–cholesterol and LDL respectively when compared with normal control. It was speculated that the extract may possess anabolic, androgenic and anti/ hypocholesterolaemic effect which might reduce the risk of predisposition to both cardiovascular and erectile dysfunctions possibly due the presence of phytoandrogens and phytonutrients like alkaloids and flavonoids.
Effect of Ethanol Extract of Terminalia catappa on Serum Reproductive Hormones in Poloxaimer Induced Hypercholesterolemic Female Wistar Rats K, Dasofunjo; C, Nyeche S.; O, Ogar B.; O, Emuru E.; O, Owu D.; O, Ugbada M.; B, Odu F.; N, Ogar U.
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3730

Abstract

This research work was carried out to access the effect of ethanol extract of Terminalia catappa, on sexual hormones in poloxamer induced hypercholesterolemia in Wistar rats. Thirty- five (35) Wistar female rats were allowed to acclimatize for a period of 7 days, in a well-ventilated room at room temperature and relative humidity of 29°C and 70% respectively with 12 hours natural light-dark cycle. They were allowed food and water ad libitum. Good hygiene was maintained by daily cleaning and removal of faeces and spills from their cages. The rats were randomly divided into 5 groups of 7 rats each. Group A: was fed with normal chow and distilled water (NC). Group B: was induced with 1.0g/kg dose of P-407 without treatment (HC). Group C: was induced with 1.0g/kg dose of P-407 and treated with atorvastatin (ATV) at 20mg/kg body weight, Group D: was induced with 1.0g/kg dose of P-407 and treated with leaves extract (HLE) at 100mg/kg body weight, Group E: was induced with 1.0g/kg dose of P-407 and treated with leaf extract (HLE) at 200mg/kg body weight/ day for 14days .The dose regimens were administered once daily for the period of the study. The rats were monitored for clinical signs and death. The result reveals that there was a significant (P<0.05) increase in serum oestrogen, progesterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) when compared with the normal, standard and hyperlipidemic control. Contrastingly, there was a significant decrease (P< 0.05) in serum testosterone and prolactin (PRL) when compared to the normal and standard control. It can be inferred from this present research work that the extract may stimulate or regulate ovulation or promote sexual health and or drive possibly due to the presence of phytonutrient or phytoandrogens.
Effect of Petroleum Ether Extract of Kigelia africana Leaf on Serum Lipid Profile in Phenyl hydrazine Induced Anaemic Female Wistar Rats O, Wilson A.; I, Nnamani V.; O, Agbo E.; O, Ugbada M.; J, Enyam; O, Emuru E.; K, Dasofunjo; C, Uduogu S.
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5259

Abstract

This research was designed to evaluate the effect of petroleum ether extract of Kigelia africana leaf on lipid profile following phenylhydrazine induced anaemia in male Wistar rats. A total of 35 male rats were distributed into five (5) groups of seven (7) rats each per group and experimental Group A served as Normal control (non-anaemic control), group B: Anaemic rats (induced with phenyl hydrazine) without treatment (anaemic control), group C; anaemic rats treated with feroton (Standard control), group D; Anaemic rats with 100mg/kg petroleum ether leaf extract Kigelia africana extract (PETLETKG1), and group E; Anaemic rats treated with 200mg/kg between petroleum ether leaf extract Kigelia africana extract (PETLETKG2). All administrations were done orally using oropharyngeal cannula once per day for 14days (2 week). Blood was collected by cardiac puncture using disposable syringe and needle to draw blood into plane sterile tubes. Thereafter, the samples were analysed using standard methods. The result depicts the significant (p<0.05) increase in serum triglyceride, high density lipoprotein and total cholesterol when compared with both normal and standard control following phenyl hydrazine induced anaemia. More so, the petroleum ether extract of K. africana significantly (p<0.05) decrease on serum low density lipoprotein when compared with both the standard and normal control. The result suggests that the extract might contain some bioactive ingredients or phytonutrients which may reduce or inhibits predisposition to complication(s) associated with cardiovascular related disorders under prolonged anaemic condition.
Effect of Petroleum Ether Extract of Kigelia africana Leaf on Serum Lipid Profile in Phenyl hydrazine Induced Anaemic Female Wistar Rats O, Wilson A.; I, Nnamani V.; O, Agbo E.; O, Ugbada M.; J, Enyam; O, Emuru E.; K, Dasofunjo; C, Uduogu S.
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5259

Abstract

This research was designed to evaluate the effect of petroleum ether extract of Kigelia africana leaf on lipid profile following phenylhydrazine induced anaemia in male Wistar rats. A total of 35 male rats were distributed into five (5) groups of seven (7) rats each per group and experimental Group A served as Normal control (non-anaemic control), group B: Anaemic rats (induced with phenyl hydrazine) without treatment (anaemic control), group C; anaemic rats treated with feroton (Standard control), group D; Anaemic rats with 100mg/kg petroleum ether leaf extract Kigelia africana extract (PETLETKG1), and group E; Anaemic rats treated with 200mg/kg between petroleum ether leaf extract Kigelia africana extract (PETLETKG2). All administrations were done orally using oropharyngeal cannula once per day for 14days (2 week). Blood was collected by cardiac puncture using disposable syringe and needle to draw blood into plane sterile tubes. Thereafter, the samples were analysed using standard methods. The result depicts the significant (p<0.05) increase in serum triglyceride, high density lipoprotein and total cholesterol when compared with both normal and standard control following phenyl hydrazine induced anaemia. More so, the petroleum ether extract of K. africana significantly (p<0.05) decrease on serum low density lipoprotein when compared with both the standard and normal control. The result suggests that the extract might contain some bioactive ingredients or phytonutrients which may reduce or inhibits predisposition to complication(s) associated with cardiovascular related disorders under prolonged anaemic condition.
Co-Authors B, Odu F. C, Nyeche S. C, Uduogu S. I, Nnamani V. J, Enyam N, Ogar U. O, Agbo E. O, Emuru E. O, Ogar B. O, Owu D. O, Ugbada M. O, Wilson A.