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All Journal African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset African Journal of Clinical Medicine and Pharmacy Research
Idu, MacDonald
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effects of Reproductive and Contractile Potential of “Makann” a Bi-herbal Formulation in Mice Itemire, Anne Oghenekevwe; Idu, MacDonald; Enitome, Bafor Evi; Gabriel, Benjamin Ogunma
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.5154

Abstract

Spontaneous uterine contractions are strictly controlled and coordinated for the success of various reproductive functions. The aim of this study was to evaluate uterine activity of bi-herbal formulation of G. kola and C. papaya roots in rodents. Ex-vivo BH cumulative concentrations response on spontaneous contractions, oxytocin induced contraction in the presence and absence of calcium and potassium induced contraction were determined. In vivo reproductive investigation in female mice and oestrogenicity in immature rats were carried out using standard methods. In uterine contractility studies, there was an increase in amplitude of spontaneous contractions with a steady decrease in the frequency. An increase in oxytocin amplitude and frequency was observed in calcium physiological salt solution (PSS) however, only amplitude was increased in oxytocin calcium-free PSS. Potassium chloride had a slight increase in amplitude. The reproductive cycle and uterothrophic assay exhibited no significant increase in relative uterine weight. The histology of the ovary, cervix and uterus showed normal cellular structural architecture. Oestrous cycle regularity and cycle number were increased in the BH treatment groups. In conclusion, an increase in female hormone as evident in oestrous cycle response validate the use of this formulation in traditional medicine for the treatment of abnormal uterine bleeding.
Phytochemistry and Uterine Contractile Effect of VLC Fractionated Bi-herbal Formulation “Makann” in Mice Itemire, Anne Oghenekevwe; Idu, MacDonald; Enitome, Bafor Evi; Ofeimun, Josephine Omose; Gabriel, Benjamin Ogunma
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.5155

Abstract

This study evaluate the phytochemistry, uterine activity of a bi-herbal formulation of G. kola and C. papaya roots in rodents. Identification of phytochemical compounds in BH was done using high performance liquid chromatography (HPLC) and fractionated with vacuum liquid chromatography and thin layer chromatography. Ex-vivo BH elicited cumulative concentrations response on spontaneous contractions of oxytocin-induced contraction in the presence and absence of calcium and potassium induced contraction. The Phytochemicals showed alkaloids (Hordenine, Cytisine, Methyl Jasmonate, Galanthamine and an unidentified compound), flavonoids (benzoic acid, isoquercetin, rutin, chlorogenic acid and an unidentified compound), phenols (eugenol and ferulic acid) and cardiac glycosides (metildigoxin, cymarin and alpha-acetyldigoxin). The fractions were tested for spontaneous uterine contractions. Uterine contraction had an isncrease in amplitude spontaneous contractions with a steady decrease in frequency. In conclusion, the results obtained from this study adhere to the folklore report, validating its myometrial contractile response with the implicated phytoconstituents.
Co-Authors Eboreime, Ofunre Ozolua Enitome, Bafor Evi Eze, Gerald Ikechi Gabriel, Benjamin O. Gabriel, Benjamin Ogunma Ifechukwude, Grace Nonye Inomo, Innocent Inomo Itemire, Anne Oghenekevwe Odjimogho, Stella E. Odjimogho, Sunny E. Ofeimun, Josephine Omose Okhuoya, John  A.  Okojie, Susan Omo Oloruntoba, Evonamhe Emmanuel