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All Journal International Journal of Advanced Health Science and Technology
Mohamed Hussein
Department of Biomedical Science, Dubai Medical College for Girls, Dubai, United Arab Emirates
Electrical & Electronics Engineering Health Professions Nursing Public Health

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Clinical Impact of Liquid Biopsy in Prostatic Cancer: A Literature Review Mohamed Hussein; Hiba Ismail
International Journal of Advanced Health Science and Technology Vol. 3 No. 1 (2023): February
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v3i1.209

Abstract

The most prev amost prev abstract alent solid tumor in men worldwide is prostate cancer. The need for biomarkers to guide management choices is critical given the frequency of prostate cancer and its relatively lengthy clinical course. Based on a patient's unique risk stratification, which considers pathologic characteristics from a prostate biopsy, prostate-specific antigen (PSA) level, imaging, and other patient factors, decisions about localized prostate cancer treatment options, such as active surveillance, surgical excision, or targeted radiation, are made. An attractive method for thorough cancer analysis is to use "liquid biopsies" made up of analytes from a peripheral blood draw. These methods can be used as prognostic and predictive biomarkers as well as ready tissue sources for molecular profiling during the course of a disease and are straightforward, safe, and simple to repeat. Researchers conduct an examination of articles that are in accordance with the issue to be studied. Articles used in literature review are obtained through  the  database  of  international  journal  providers  through  PubMed,  we  investigated eleven clinical studies and discussed what happened in these clinical studies and the extent of the effectiveness of liquid biopsy in  prostatic cancer, in one study there was relative impact of common circulating tumor DNA alterations on patient response to the most widely used large, randomize advanced prostate cancer. Other studies reported that ZNF660 methylation analysis can potentially help to stratify low-/intermediate-grade PCs into indolent vs. more aggressive subtypes. Another study found that tumor-derived biomarkers in platelets of CRPC patients enabled prediction of the outcome after abiraterone therapy with higher accuracy than baseline serum PSA or PSA response. One study reported that de novo positive CTC count after androgen deprivation therapy is probably due to a passive mechanism associated with the destruction of the tumor. In this review, we suggest that liquid biopsy could be used as biomarker for prostatic cancer, Further studies are needed to enhance liquid biopsy efficacy.
Can Osteoarthritis be Cured by Mesenchymal stem cells (MSCs)? A Literature Review Mohamed Hussein
International Journal of Advanced Health Science and Technology Vol. 3 No. 3 (2023): June
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v3i3.234

Abstract

Osteoarthritis (OA) is a degenerative joint disease that affects millions of people worldwide. The disease frequently results in discomfort, edema, and stiffness, which can impair movement, make everyday tasks challenging, and even render a person disabled. Since osteoarthritis is presently incurable, researchers are working hard to find new treatments. Adult Mesenchymal stem cells (MSCs) are the most common stem cells used in the therapy of OA in clinical trials. They are simple to extract for researchers from bone marrow or adipose. Depending on the kind of tissue that contains them, MSCs can develop into cartilage, bone, muscle, tendon, ligaments, or fat. For this reason, scientists are researching MSCs in OA stem cell therapies. According to research, MSCs produce substances that promote healing and reduce pain. According to some research, they may aid in reducing pain, swelling, and loss of motion when injected into a joint. Researchers conduct an examination of articles that are in accordance with the issue to be studied. Articles used in literature review are obtained through the database of international journal providers through PubMed, we investigated clinical studies and discussed what happened in these clinical studies and the extent of the effectiveness of stem cells in treatment of osteoarthritis. Different patients have responded differently to this therapy. While some people have experienced pain others have not. Research is still required to determine whether stem cell therapies for OA are effective and why some people respond to the therapy more favorably than others.
Co-Authors Hiba Ismail