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All Journal Jurnal Impresi Indonesia Journal of Social Research
Renni Yuniati
Universitas Diponegoro, Indonesia
Religion Humanities Computer Science & IT Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Social Sciences

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Efficacy of Adjuvant Therapy Curcuma Longa Rhizome Extract and Moringa Oleifera Leaf Extract to Wound Healing in Leprosy Ulcer Patients Renni Yuniati; Farmaditya Eka Putra Mundhofir; Sylvia Christiana Sugianto
Journal of Social Research Vol. 4 No. 6 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i6.2565

Abstract

Leprosy (Morbus Hansen) is a chronic infectious disease caused by Mycobacterium leprae, primarily affecting the peripheral nerves and leading to sensory loss and the formation of chronic ulcers. This study investigates the efficacy of Curcuma longa rhizome and Moringa oleifera leaf extracts, known for their antibacterial and anti-inflammatory properties, in promoting wound healing in leprosy-related ulcers. Utilizing a pre-post, randomized, single-blinded controlled trial design, the study was conducted at Kelet Regional Hospital, Jepara, from January to April 2024. Participants included leprosy ulcer patients with a mean disease duration of 101.5 months, predominantly male (63.6%), and largely in the 51–60 age group (39.4%). Results indicated significant improvements in PUSH (Pressure Ulcer Scale for Healing) scores from pre-test to post-test within both the intervention and control groups (p<0.001). However, intergroup analysis showed no statistically significant difference in PUSH scores between groups (pre-test p=0.669; post-test p=0.198). These findings suggest that while C. longa and M. oleifera extracts have promising therapeutic potential in enhancing ulcer healing, their clinical efficacy may be limited by factors such as oral bioavailability. This research contributes to the limited literature on the use of plant-based adjunctive therapies in leprosy ulcer management and underscores the need for further studies with larger samples and improved delivery mechanisms to optimize clinical outcomes.
Efektivitas Ekstrak Kaempferia Galanga Terhadap Proses Penyembuhan Luka Renni Yuniati; Farah Chilwa Hidayati; Muhammad Auzinal Haq; Muhammad Ahda Sabila
Jurnal Impresi Indonesia Vol. 4 No. 6 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

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Abstract

Wound healing is a complex biological process that involves various stages of tissue regeneration. In the world of traditional medicine, Kaempferia galanga is widely known for its content of active compounds that have anti-inflammatory, antimicrobial, and antioxidant properties. This study aims to systematically review the adjuvant therapeutic efficacy of Kaempferia galanga rhizome extract in accelerating wound healing based on published experimental studies. This research method uses a systematic literature review approach by examining articles from national and international scientific databases over the past ten years. The results of the study show that the administration of Kaempferia galanga extract can increase re-epithelialization, reduce inflammatory response, and accelerate the formation of granulated tissue. Overall, rhizome-based adjuvant therapy Kaempferia galanga has the potential to be an alternative in the development of more natural and safe wound-healing agents. The conclusions of this study emphasize the importance of further exploration through clinical trials to ensure the effectiveness and safety of its long-term use in medical practice.
Co-Authors Farah Chilwa Hidayati Farmaditya Eka Putra Mundhofir Muhammad Ahda Sabila Muhammad Auzinal Haq Sylvia Christiana Sugianto