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All Journal Indonesian Journal of Pharmaceutical Education
Ni Nyoman Wahyu Udayani
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, Denpasar, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Antioxidant Activity and Blood Glucose-Lowering Effect of Sweet Potato Leaf Biscuits in Alloxan-Induced Rats Ni Nyoman Wahyu Udayani; Ni Kadek Ganis Wulandari; Ni Komang Ary Agustina Berliana Putri; Ni Putu Trisna Meika; I Putu Aldy Mahendra
Indonesian Journal of Pharmaceutical Education Vol 6, No 1 (2026): January–April 2026
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v6i1.37311

Abstract

Sweet potato leaves are a potential source of natural antioxidants because they contain bioactive compounds such as flavonoids and anthocyanins. This study aimed to evaluate the antioxidant activity of sweet potato leaf biscuits and their effect on blood glucose levels in alloxan-induced male rats. Biscuits were formulated using sweet potato leaf simplicia at three concentrations, namely 30 g (F1), 40 g (F2), and 50 g (F3). A total of 30 experimental rats were divided into six groups: normal control, negative control, positive control, and three treatment groups receiving F1, F2, or F3 biscuits. The test preparations were administered orally once daily for 21 days. Organoleptic evaluation, proximate analysis, antioxidant activity using the DPPH method, and blood glucose measurements were performed. Blood glucose data were analyzed using one-way ANOVA followed by the LSD post hoc test. The results showed that all biscuit formulations met the proximate quality requirements according to SNI 01-2973-1992. Antioxidant testing demonstrated that F3 had the strongest antioxidant activity, as indicated by the lowest IC₅₀ value among the tested formulations. F3 also produced the greatest reduction in blood glucose levels in alloxan-induced rats. These findings suggest that biscuits containing a higher proportion of sweet potato leaf simplicia may provide greater antioxidant activity and better glucose-lowering potential.
Co-Authors I Putu Aldy Mahendra Ni Kadek Ganis Wulandari Ni Komang Ary Agustina Berliana Putri Ni Putu Trisna Meika