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All Journal KOLONI Jurnal Natural
Zulfitri Zulfitri
Faculty of Medicine, Universitas Syiah Kuala
Civil Engineering, Building, Construction & Architecture Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Antibiofilm activity of Gayo Arabica coffee (Coffea arabica L.) bean ethanolic extract against Pseudomonas aeruginosa and Candida albicans: in vitro and in silico studies Raisha Fathima; Rima Ristianti; Rizkiyah Rizkiyah; Zulfitri Zulfitri; Tristia Rinanda
Jurnal Natural Vol. 26 No. 1 (2026)
Publisher : Faculty of Mathematics and Natural Science (FMIPA), Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v26i1.926

Abstract

Microbes form infectious biofilms to avoid antibiotic mechanisms, leading to the rise of antibiotic resistance. This phenomenon demands massive development of novel antibiofilm agents. Coffee plants have been investigated as antibiofilm agents despite their value as a popular export commodity. Gayo Arabica coffee, a signature product of Aceh, represents a sustainable and locally abundant natural resource. The aim of this study was to determine the antibiofilm activity of Gayo Arabica coffee bean extract against two of the most well-known biofilm producers, namely Pseudomonas aeruginosa and Candida albicans. The minimum inhibitory concentrations of the 96% ethanol-macerated coffee beans were identified against both microbes. The antibiofilm activity was evaluated based on inhibition and degradation assays. Chemical profiling of the extract was performed using Gas Chromatography-Mass Spectrometry, followed by molecular docking to assess interactions between compounds and biofilm-associated proteins in P. aeruginosa and C. albicans. The extract demonstrated antibiofilm activities against both microbes, which may be associated with the dominant compounds, particularly caffeine, hexadecanoic acid, and cis-13,16-docosadienoic acid. Caffeine had the strongest binding affinity to target proteins based on the docking analysis. This study exhibits the potent antibiofilm activity of Gayo Arabica coffee bean extract against P. aeruginosa and C. albicans. Keywords: biofilm, resistance, Pseudomonas aeruginosa, Candida albicans, Gayo coffee
Correlation Between Left Ventricular Ejection Fraction and Anemia in Patients With Congestive Heart Failure in dr. Zainoel Abidin General Hospital Banda Aceh Arief Yanda; Andra Dea Riskia; Azhari Gani; Zulfitri Zulfitri
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.813

Abstract

Congestive heart failure is a condition in which the heart is unable to pump sufficient blood to meet the body’s needs. Left ventricular ejection fraction (LVEF), obtained from echocardiography, reflects the proportion of blood ejected by the left ventricle during each contraction. Anemia is defined as a reduced number of red blood cells or decreased oxygen-carrying capacity, resulting in inadequate oxygen delivery to tissues. It is a common comorbidity in heart failure and an independent predictor of morbidity and mortality. This study aimed to determine the correlation between LVEF and anemia in patients with congestive heart failure. This study employed an observational analytic design with a cross-sectional design. A total of 137 subjects were selected using consecutive sampling from medical records. Among the subjects, 63 (46.0%) had HFrEF, 21 (15.3%) HFmrEF, and 53 (38.7%) HFpEF. Anemia was found in 77 patients (56.2%), consisting of mild (57.1%), moderate (33.8%), and severe anemia (9.1%). Spearman correlation analysis showed a significant association between LVEF and anemia (p = 0.019). A significant correlation was found between LVEF and anemia in patients with congestive heart failure.
Co-Authors Andra Dea Riskia Arief Yanda Azhari Gani Raisha Fathima Rima Ristianti Rizkiyah Rizkiyah Tristia Rinanda