Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Journal of Pharmaceutical and Sciences.
Asyrun Alkhairi Lubis
Department of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, 20118, Indonesia. PUI Phyto Degenerative & Lifestyle Medicine, Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Efek Nefroprotektif Ekstrak Bunga Telang (Clitoria ternatea L.) Pada Tikus Model Nefrotoksisitas: Analisis Biokimia, Histopatologi, Antioksidan, dan Sitokin Asyrun Alkhairi Lubis; Novitaria Br Sembiring; Razoki Razoki; Citra Alvia Nazmi Siregar; Ade Yasmin Kaban; Qori Tari Jelitta Pandiangan; Kristia Andini Sitanggang
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1444

Abstract

Background: Butterfly pea flower (Clitoria ternatea L.) is rich in antioxidants and bioactive compounds that may protect the kidney from nephrotoxic injury. Objective: This study aimed to evaluate the nephroprotective effect of ethanolic extract of butterfly pea flower in gentamicin-induced rats. Methods: This in vivo experimental study used 30 male Wistar rats divided into five groups: normal control, negative control, and three treatment groups receiving butterfly pea flower extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally, while gentamicin 100 mg/kgBW was given intraperitoneally. Parameters observed included BUN, urea, IL-6, TNF-α, renal morphology, kidney weight, and histopathology. Results: Gentamicin increased BUN, urea, IL-6, and TNF-α levels and caused histopathological damage and morphological changes in the kidney. Administration of butterfly pea flower extract reduced inflammatory response, improved histopathology, and restored renal morphology and kidney weight toward normal. The best histopathological improvement was observed at 200 mg/kgBW, whereas the strongest anti-inflammatory effect was found at 400 mg/kgBW. Conclusion: Ethanolic extract of butterfly pea flower has potential as a nephroprotective agent against gentamicin-induced nephrotoxicity.  
Co-Authors Ade Yasmin Kaban Citra Alvia Nazmi Siregar Kristia Andini Sitanggang Novitaria Br Sembiring Qori Tari Jelitta Pandiangan Razoki Razoki