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All Journal Jurnal Pharma Bhakta Illea
Wahyuni Agus
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology

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REVIEW: POLYCYCLIC AROMATIC HYDROCARBON CONTAMINATION IN MARINE LIFE AND ITS IMPLICATIONS FOR FOOD SAFETY AND PUBLIC HEALTH: REVIEW : KONTAMINASI POLIKLIK HIDROKARBON AROMATIK PADA BIOTA LAUT DAN IMPLIKASINYA TERHADAP KEAMANAN PANGAN SERTA KESEHATAN MASYARAKAT Fauziah Hasdin; Wahyuni Agus
Illea : Journal of Health Sciences, Public Health and Medicine Vol. 2 No. 2 (2026): Juni
Publisher : Education and Talent Development Center Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/illea.v2i2.5077

Abstract

Polycyclic Aromatic Hydrocarbons (PAHs) are persistent organic compounds that extensively contaminate marine environments as a result of anthropogenic activities such as industrial processes, transportation, fossil fuel combustion, and petroleum exploration. The hydrophobic and lipophilic properties of PAHs enable these compounds to accumulate easily in sediments and marine biota tissues, thereby increasing their potential to enter the human food chain. This article aims to examine PAH contamination in marine biota and its impacts on food safety and public health. The study employed a narrative review approach by analyzing scientific publications published between 2015 and 2025 obtained from PubMed, ScienceDirect, and Google Scholar databases. The review findings indicate that PAHs in marine environments originate from both petrogenic and pyrogenic sources and subsequently accumulate in aquatic organisms through bioaccumulation and biomagnification processes. Exposure to PAHs in marine biota causes oxidative stress, reproductive disorders, tissue damage, and deterioration of aquatic ecosystem quality. Furthermore, the consumption of seafood contaminated with PAHs may increase the risk of cancer, immune system disorders, and other health problems in humans. Therefore, PAH contamination in marine environments represents a serious threat to food safety and public health. Environmental monitoring, pollution source control, and the implementation of stricter food safety regulations are essential to minimize the adverse impacts of PAHs on ecosystems and human health.
THERAPEUTIC SAFETY AND RATIONALITY IN CLINICAL PHARMACY: THE ROLE OF PRECLINICAL STUDIES AND THE ZEBRAFISH MODEL IN SUPPORTING CLINICAL DECISION-MAKING: KEAMANAN DAN RASIONALITAS TERAPI DALAM FARMASI KLINIK: KONTRIBUSI STUDI PREKLINIK DAN MODEL ZEBRAFISH TERHADAP PENGAMBILAN KEPUTUSAN KLINIS Fauziah Hasdin; Wahyuni Agus
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.169

Abstract

Background: Clinical pharmacy practice requires the implementation of safe and rational therapies to optimize clinical outcomes and minimize the risk of adverse drug reactions. Limited availability of early clinical data, particularly for newly developed drugs and the increasing use of natural products, poses challenges in therapeutic decision-making. Under these conditions, preclinical studies serve as an essential source of early evidence for evaluating compound safety prior to human use. Objective: This review aims to examine the role of preclinical studies using the zebrafish (Danio rerio) model in supporting clinical decision-making in clinical pharmacy practice. Methods: This article was conducted using a narrative review approach of national and international scientific literature addressing therapeutic safety, clinical pharmacy, preclinical studies, and the application of the zebrafish model. Result: The literature indicates that zebrafish offer significant advantages as an efficient, sensitive, and translationally relevant preclinical model for toxicity testing and drug safety assessment, including natural product–based compounds. Integration of preclinical data with clinical considerations contributes to improved accuracy of therapeutic decisions and strengthens the role of clinical pharmacists in ensuring patient safety. Conclusions: Zebrafish-based preclinical studies represent a significant supportive component in evidence-based clinical pharmacy practice.
Co-Authors Fauziah Hasdin Fauziah Hasdin