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All Journal Griya Widya: Journal of Sexual and Reproductive Health Biomedika
Nur Mahmudah
Universitas Muhammadiyah Surakarta, Surakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Other

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Usia dan Status Perkawinan dengan kejadian Fibroadenoma Mammae di Kota Surakarta Nur Mahmudah; Povitasari Povitasari; Ayu Indah Sulistyo
Griya Widya: Journal of Sexual and Reproductive Health Vol. 5 No. 2 (2026): Griya Widya: Journal of Sexual and Reproductive Health
Publisher : Nur Science Institute and Perkumpulan Keluarga Berencana Indonesia (PKBI) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/griyawidya.v5i2.2742

Abstract

Background: Breast tumor incidence in Indonesia based on clinical breast examinations shows an increase every year. Fibroadenoma mammae (FAM) is one of the most common types of benign tumors in young women. Several factors that influence the growth of FAM include increased estrogen hormone activity in young women under 30 years of age. Method: The method used in this study was a case-control design, a total of 54 patients were included, divided into 2 groups, 27 FAM patients (cases) and 27 non-FAM patients as controls. The data analyzed by chi square and logistic regression test. Result: The results showed that there was a significant relationship between age and the incidence of FAM (p < 0.05), where patients of reproductive age suffered more from FAM than menopausal patients. A significant relationship between marital status and FAM (p> 0.05), where most FAM suffered from unmarried women. Age and marital status had a 63.1% influence on the incidence of FAM. Implication: The government and public should be aware that fibroadenoma mammary is a risk factor for young and unmarried women, so it is necessary to take preventive measures against the etiology of fibroadenoma mammary which is mainly caused by genetic mutations and marriage reduces the risk of fibroadenoma mammary occurrence. Novelty: This study provides knowledge that age and unmarried status increase the risk of breast fibroadenoma.
INVESTIGATION OF THE ANTIBACTERIAL EFFICACY OF DERSONO WATER APPLE LEAVES (SYZYGIUM MALACCENSE) AS A SUBSTITUTE THERAPY FOR STREPTOCOCCUS PYOGENES INFECTIONS Devi Usdiana Rosyidah; Nur Mahmudah; Sa’idatul Fithriyah; Retno Sintowati
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12007

Abstract

Streptococcus pyogenes caused different illnesses, including pharyngitis and dermatological infections. The Dersono water apple leavesSyzygium malaccense) are recognized for their bioactive ingredients, which may serve as antibacterial agents. This study purpose was to determine the antibacterial potential of ethanol extract and acetone fraction of Syzygium malaccense against Streptococcus pyogenes infection. This research was a laboratory xperiment, a post-test only with control group design. Assessing growth inhibition by measuring the diameter of halo around the well of blood agar plate. Statistical tests using the Sapiro-Wilk test, Lavene test, Kruskal Wallis est and Mann-Whitney test. The study's findings demonstrated that the ethanol extract 25% (11.80 mm) and 50% (16.51) concentrations and acetone fraction of Dersono water apple leaves, at 25% (11.25 mm) and 50% (12.08) concentrations, had strong inhibitory power. The concentrations of 6.25% (8.15 mm) and 12.50% (9.63 mm), the ethanol extract's inhibitory power was superior than the concentrations of 6.25% (4.42 mm) and 12.50% (3.38 mm) acetone fraction, had moderate range. Both the ethanol extract and the acetone fraction's phytochemical analyses identified alkaloids, tannins, and saponins. The conclusion was ethanol extract and acetate fraction of Dersono water apple leaves have antibacterial effects against Streptococcus pyogenes.
Co-Authors Ayu Indah Sulistyo Devi Usdiana Rosyidah Povitasari Povitasari Retno Sintowati Sa’idatul Fithriyah