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This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Camelia Maktur
Pharmacy Diploma Program, STIKes Widya Dharma Husada Tangerang, Banten, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Prediction of the Potential Active Compounds in Cucumber (Cucumis sativus L) against Hypertension using Pharmacological Network (Cytoscape) Camelia Maktur; Febrial Hikmah
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26201

Abstract

Hypertension is the leading cause of heart disease, kidney failure and stroke in Indonesia. Antihypertensive drugs have proven effective in managing blood pressure levels. However, long-term use of these medications may lead to side effects, reduce patient compliance and increased healthcare costs. Various studies have reported the cucumber (Cucumis sativus L) effect in controlling blood pressure. The purpose of this study is to investigate the molecular basis of these effects and identify the specific pathways involved. This research is a systematic review in silico network pharmacology analysis to forecast the antihypertensive potential of cucumber derived active compounds. By employing computational methods to explore plant-based therapeutic effects, the study identified bioactive components and their targets through the ChEMBL database, followed by protein validation using the Open Targets Platform. The findings contribute to the growing evidence that cucumber plants may play a role in hypertension management through multi-target mechanism.
Prediction of the Potential Active Compounds in Cucumber (Cucumis sativus L) against Hypertension using Pharmacological Network (Cytoscape) Camelia Maktur; Febrial Hikmah
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26201

Abstract

Hypertension is the leading cause of heart disease, kidney failure and stroke in Indonesia. Antihypertensive drugs have proven effective in managing blood pressure levels. However, long-term use of these medications may lead to side effects, reduce patient compliance and increased healthcare costs. Various studies have reported the cucumber (Cucumis sativus L) effect in controlling blood pressure. The purpose of this study is to investigate the molecular basis of these effects and identify the specific pathways involved. This research is a systematic review in silico network pharmacology analysis to forecast the antihypertensive potential of cucumber derived active compounds. By employing computational methods to explore plant-based therapeutic effects, the study identified bioactive components and their targets through the ChEMBL database, followed by protein validation using the Open Targets Platform. The findings contribute to the growing evidence that cucumber plants may play a role in hypertension management through multi-target mechanism.
Co-Authors Febrial Hikmah