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All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Sella Asharianti
Pharmacy Study Program, Sekolah Tinggi Ilmu Farmasi Riau (STIFAR), Pekanbaru, Riau, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Optimization, Characterization, and Antioxidant Activity of Sunflower Oil-Based SNEDDS using Response Surface Method Rodhia Ulfa; Gressy Novita; Sella Asharianti
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26418

Abstract

This study aims to optimize, characterize, and evaluate the antioxidant activity of sunflower seed oil-based SNEDDS using Tween 80 and PEG 400. The study utilizes Simplex Lattice design and Response Surface Methodology to obtain a formula with the best physical characteristics and efficacy. Sunflower seed oil was selected due to its high content of essential fatty acids and antioxidants. The optimization method involved determining the ratio of surfactant, cosurfactant, and oil, as well as characterization tests of particle size, polydispersity index, zeta potential, emulsification time, and antioxidant activity. The results showed an optimal formula with a nano particle size of 13 nm ± 0.346, low polydispersity index (0.161 ± 0.067), and zeta potential of -21.8 mV ± 0.577, ensuring physical stability. The antioxidant activity of SNEDDS remained high with an IC50 of 18.06 μg/mL. Formulation verification through statistical analysis confirmed the consistency of experimental results with optimization software predictions. In conclusion, the optimized sunflower seed oil SNEDDS offers an innovative oral formulation that is efficient, stable, and safe, with the potential to improve bioavailability, pharmacological activity, and the utilization of local vegetable oils in modern pharmacy.
Optimization, Characterization, and Antioxidant Activity of Sunflower Oil-Based SNEDDS using Response Surface Method Rodhia Ulfa; Gressy Novita; Sella Asharianti
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26418

Abstract

This study aims to optimize, characterize, and evaluate the antioxidant activity of sunflower seed oil-based SNEDDS using Tween 80 and PEG 400. The study utilizes Simplex Lattice design and Response Surface Methodology to obtain a formula with the best physical characteristics and efficacy. Sunflower seed oil was selected due to its high content of essential fatty acids and antioxidants. The optimization method involved determining the ratio of surfactant, cosurfactant, and oil, as well as characterization tests of particle size, polydispersity index, zeta potential, emulsification time, and antioxidant activity. The results showed an optimal formula with a nano particle size of 13 nm ± 0.346, low polydispersity index (0.161 ± 0.067), and zeta potential of -21.8 mV ± 0.577, ensuring physical stability. The antioxidant activity of SNEDDS remained high with an IC50 of 18.06 μg/mL. Formulation verification through statistical analysis confirmed the consistency of experimental results with optimization software predictions. In conclusion, the optimized sunflower seed oil SNEDDS offers an innovative oral formulation that is efficient, stable, and safe, with the potential to improve bioavailability, pharmacological activity, and the utilization of local vegetable oils in modern pharmacy.
Co-Authors Gressy Novita Rodhia Ulfa