Introduction: Cardiovascular emergencies are the leading cause of death worldwide. In disaster-prone areas, this condition can increase because people are at risk of experiencing stress due to disasters. This study aimed to analyze the predictors of physical, psychological, and social vulnerability factors for the prevention of cardiovascular emergencies. Methods: This was a cross-sectional study. A total of 150 respondents with high-risk criteria for cardiovascular diseases and living in disaster-prone areas in West Sumbawa, Indonesia, were selected using the accidental sampling technique. The variables in this study were human resource preparedness, infrastructure readiness, availability of policy systems, access system readiness, and physical, psychological, and social vulnerability. Data were collected via questionnaires and analyzed using Fisher’s exact test and binary logistic regression (α<0.05). Results: Economic status and social support from health workers and family members were associated with all vulnerability domains. Good economic status was significantly related to reduced physical (OR=0.075;95% CI=0.023–0.250) and social vulnerability (OR=0.052;95% CI=0.011–0.250), while low economic status was related to increased psychological vulnerability (OR=2.459;95% CI=1.022–5.917). Health worker support was a critical protective factor against physical vulnerability (OR=0.042;95% CI=0.004–0.476), and family support strongly mitigated social vulnerability (OR=0.080;95% CI=0.018–0.352). Conclusions: Socioeconomic stability and interpersonal support systems are related to reducing health vulnerability in cardiovascular emergencies. Interventions should prioritize strengthening household economic resilience, enhancing family based psychosocial support, and integrating trained health workers into disaster preparedness frameworks to improve cardiovascular outcomes in pregnant women.