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All Journal Jurnal Indonesia Sosial Sains Cerdika: Jurnal Ilmiah Indonesia
Putu Ngurah Pradnya Wibawa
UPTD Dawan II Community Health Center, Indonesia
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Neuroscience Physics Public Health Social Sciences

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Efficacy and Safety of Lenacapavir for HIV Pre-Exposure Prophylaxis (Prep): A Systematic Review Putu Ngurah Pradnya Wibawa; Ni Putu Lia Juliantini; Ni Luh Putu Serly Ekayanti
Jurnal Indonesia Sosial Sains Vol. 7 No. 5 (2026): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v7i5.2316

Abstract

Lenacapavir, an antiretroviral agent, is a candidate for HIV prophylaxis, distinguished by its long-acting formulation, which facilitates biannual administration for preventive care. The objective of this investigation is to assess the efficacy and safety profile of Lenacapavir, drawing upon the findings of extant research. This scoping review analyzed articles published between march 2016 and march 2026 from PubMed, ScienceDirect, and OpenAlex. The inclusion criteria comprised English-language cohort studies, case-control studies, and cross-sectional studies examining the association between NAFLD and the risk of CKD. Fifteen articles were selected following a rigorous screening process. Lenacapavir is a highly effective HIV preventive drug that can reduce the risk of HIV transmission among various populations, including pregnant women, homosexual and heterosexual individuals, and others. The reported side effects are generally mild and not severe. Lenacapavir signifies a significant advancement in the realm of HIV prevention, especially for individuals at elevated risk who encounter challenges with consistent daily medication adherence. The effective global deployment of this intervention hinges on several critical factors: guaranteeing equitable accessibility, ensuring affordability within low- and middle-income nations, and upholding rigorous HIV testing protocols to mitigate the potential for viral resistance.
Presepsin and Interleukin-6 as Early Diagnostic Biomarkers of Sepsis: A Scoping Review Putu Ngurah Pradnya Wibawa; Ni Putu Lia Juliantini; Ni Luh Putu Serly Ekayanti
Cerdika: Jurnal Ilmiah Indonesia Vol. 6 No. 4 (2026): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v6i4.3433

Abstract

Sepsis is a life-threatening medical condition with high morbidity and mortality, making early detection very important to improve patient outcomes. Conventional biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) have limitations in sensitivity and specificity, so more accurate biomarkers are needed. This study aims to analyze the role of presepsin and interleukin-6 (IL-6) as early diagnostic biomarkers of sepsis using a scoping review approach. The method used was a literature review of articles published between 2016–2026 from PubMed, ScienceDirect, and other sources based on specific inclusion and exclusion criteria. A total of 10 articles were included in this study. The results show that presepsin has high diagnostic accuracy, with AUC values ranging from 0.76 to 0.94, and is strongly associated with disease severity and patient mortality. Meanwhile, IL-6 acts as an inflammatory biomarker that significantly increases in severe cases and has good prognostic value for mortality. In addition, the combination of presepsin and IL-6 improves diagnostic accuracy and prediction compared to using a single biomarker. In conclusion, presepsin and IL-6 are complementary biomarkers in the diagnosis and prognosis of sepsis. Presepsin is more specific to bacterial infection, while IL-6 reflects the inflammatory response. Their combination has strong potential to improve early detection, risk assessment, and clinical decision-making in sepsis management.
Co-Authors Ni Luh Putu Serly Ekayanti Ni Luh Putu Serly Ekayanti Ni Putu Lia Juliantini Ni Putu Lia Juliantini