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All Journal JOURNAL LA MEDIHEALTICO Journal of Community Health Provision
Nasruddin Andi Mappaware
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Literature Review: The Effect of Folic Acid and Vitamin B6 Content in Dates on Ovulation Quality in Women of Childbearing Age Sarmila Mustakim; Nasruddin Andi Mappaware; Suzanna J.M Siegers
Journal of Community Health Provision Vol. 6 No. 2 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i2.959

Abstract

Ovulation quality is a crucial component of reproductive health in women of childbearing age because it plays a role in successful fertilization and the sustainability of the reproductive process. Ovulation quality is influenced by oocyte maturation, follicle development, hormonal balance, and ovarian environmental conditions. Nutritional status, particularly adequate intake of folic acid and vitamin B6, is known to play a crucial role in supporting this process. Dates (Phoenix dactylifera L.) are a natural food source containing folic acid, vitamin B6, and bioactive compounds that have the potential to support ovarian function. This study aims to examine the effect of folic acid and vitamin B6 content in dates on ovulation quality in women of childbearing age. The method used was a literature review with a narrative design. Data were obtained from national and international journal articles relevant to the nutritional content of dates, the role of folic acid and vitamin B6, and their relationship to ovulation quality. Data were analyzed descriptively by grouping findings based on the biological mechanisms involved in ovulation. The study results indicate that folic acid plays a role in deoxyribonucleic acid synthesis and oocyte maturation through the one-carbon metabolic pathway, while vitamin B6 plays a role in regulating homocysteine ​​metabolism and ovarian metabolic balance. Furthermore, the bioactive compounds in dates have the potential to help suppress oxidative stress, which can damage oocyte quality. The conclusions of this study suggest that dates have the potential to support ovulation quality through complementary nutritional and biological mechanisms, although further clinical research is needed to strengthen the evidence directly.
The Effect of Ajwa Date (Phoenix dactylifera L., var. Ajwa) Phytonutrients in the Regulation of Male Reproductive Hormones (LH, FSH, Testosterone): A Literature Review Mutiara Mutiara; Nasruddin Andi Mappaware; Nasaruddin Nawir
Journal of Community Health Provision Vol. 6 No. 2 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i2.960

Abstract

Regulation of reproductive hormones is an important component of male reproductive health because it plays a crucial role in spermatogenesis, sexual function, and fertility. The balance of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone is influenced by the integrity of the hypothalamic–pituitary–gonadal axis and the condition of the testicular microenvironment. Oxidative stress and inflammation are known to impair Leydig cell function and reduce the efficiency of steroidogenesis. Ajwa dates (Phoenix dactylifera L., var. Ajwa) are a natural food source rich in phytonutrients, including polyphenols and flavonoids, which exhibit antioxidant activity and protective effects on testicular tissue. This literature review aims to examine the role of Ajwa date phytonutrients in the regulation of male reproductive hormones, particularly LH, FSH, and testosterone. The method used was a literature review with a narrative review design, conducted through searches of the PubMed, Google Scholar, and ScienceDirect databases. The literature analyzed included experimental studies, clinical studies, and review articles published within the last ten years. Data were analyzed descriptively and narratively by grouping findings according to key biological mechanisms. The results indicate that phytonutrients from Ajwa dates and other parts of the date palm contribute to the reduction of oxidative stress and inflammation, improvement of testicular structure and function, and enhancement of testosterone production, with generally minimal changes in LH and FSH levels. In addition, under certain conditions, Ajwa dates show potential as hormonal modulators that help stabilize the balance of the hypothalamic–pituitary–gonadal axis. The conclusion of this review suggests that Ajwa dates have the potential to support the regulation of male reproductive hormones, although further clinical studies are still required.
Literature Review: The Effect of Ajwa Date Consumption on Menstrual Pain Intensity in Women of Reproductive Age Andi Bayan Zhafirah; Nasruddin Andi Mappaware; Amelia Abdullah
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2721

Abstract

Dysmenorrhea is one of the most common menstrual disorders among women of reproductive age, characterized by lower abdominal pain due to increased prostaglandin levels that trigger excessive uterine contractions. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, their long-term use may cause adverse effects. Therefore, natural and safe alternatives are needed, such as Ajwa dates (Phoenix dactylifera L.), which contain bioactive compounds like flavonoids, phenols, and phytoestrogens that may reduce menstrual pain through hormonal regulation and anti-inflammatory mechanisms. This study aimed to review the effect of Ajwa date consumption on the intensity of menstrual pain in women of reproductive age. This research employed a literature review design with a narrative approach. Data were obtained from five relevant national and international journals that discussed the effects of Ajwa dates on estrogen, progesterone, and inflammatory mechanisms. The collected data were analyzed qualitatively to identify the relationship between variables and summarize the main findings of each study. The review showed that Ajwa dates can increase estrogen and progesterone levels, which help suppress prostaglandin production, relax uterine muscles, and inhibit cyclooxygenase enzymes (COX-1 and COX-2). Additionally, their nutritional content, such as vitamins and minerals, provides a natural analgesic effect that supports physiological balance during menstruation. Consumption of Ajwa dates has the potential to serve as a safe and effective non-pharmacological therapy to reduce menstrual pain intensity through synergistic hormonal, anti-inflammatory, and nutritional mechanisms
Co-Authors Amelia Abdullah Andi Bayan Zhafirah Mutiara Mutiara Nasaruddin Nawir Sarmila Mustakim Suzanna J.M Siegers