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All Journal Journal of Innovation Research and Knowledge The ASEAN Journal of Military and Preventive Medicine
Arif Rachman
Department of Cell Biology and Biomolecular, Faculty of Medicine, Indonesian Defense University, Bogor, Indonesia
Humanities Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Social Sciences

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Stem Cell Transplantation Therapy in Systemic Sclerosis: A Systematic Review Arif Rachman; Prihati Pujowaskito; Arfiyanti Arfiyanti; Arya Duta Dharma; Dinda Puspa; Jafar Elyas; Ilham Syahputro; Nuzuludz Dzikra; Nabil Ramaseno; Ni Made Ayu Widiyasih; Muhammad Zhafran Maulana; Shalya Regita; Ruth Je Deborah Octavia
The ASEAN Journal of Military and Preventive Medicine Vol. 2 No. 1 (2025): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v2i1.20

Abstract

Background: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by systemic inflammation, vascular dysfunction, progressive fibrosis, multiorgan involvement, and impaired quality of life. Autologous hematopoietic stem cell transplantation (HSCT) has been investigated as an option for patients with severe SSc who respond inadequately to conventional immunosuppressive therapy. Methods: A systematic search was conducted in the Cochrane Library and PubMed using terms related to stem cell transplantation, hematopoietic stem cell transplantation, systemic sclerosis, stem cell therapy, immunomodulatory therapy, and cyclophosphamide. Eligible studies were randomized controlled trials involving adults with diffuse or limited SSc, autologous HSCT as the intervention, and cyclophosphamide or other immunomodulatory therapy as the comparator. Study selection, data extraction, and risk-of-bias assessment were performed systematically, and the selection process was documented using a PRISMA flow diagram. Discussion: Three randomized controlled trials involving 250 participants were included. Selective non-myeloablative HSCT improved event-free survival, while selective myeloablative HSCT showed benefits in survival analysis and skin-related outcomes. Quality-of-life improvements were reported with selective HSCT approaches. However, HSCT was associated with a higher risk of serious adverse events than cyclophosphamide. Conclusion: Autologous HSCT may provide clinical benefit in selected patients with severe SSc, but careful risk-benefit assessment, strict patient selection, and long-term monitoring are essential.
HOW PERCEPTIONS OF COST, ACCESS, AND QUALITY DRIVE OUTPATIENT REVISIT INTEREST Gaby Priscillia Putri; Mugi Wahidin; Anggun Nabila; Susi Shorayasari; Arif Rachman
Journal of Innovation Research and Knowledge Vol. 5 No. 12 (2026): Mei 2026
Publisher : Bajang Institute

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Abstract: This research was motivated by a decrease in interest in revisiting patients at RSGM X, Jakarta, from 40.5% (2020) to 16.2% (2024).The purpose of the study was to analyze the relationship between cost perception, access, and service quality with outpatient revisit interest.The research method used a cross-sectional design of 63 patients by 2025 with quota sampling technique. Bivariate analysis used Chi-Square and Prevalence Ratio (PR) tests. The results showed that 57.1% of patients had low interest in repeat visits. The majority of respondents perceived high costs (74.6%), unaffordable access (68.3%), but good quality (61.9%). There was a significant relationship between cost perception (PR=5,787), access (PR=3,721), and quality (PR=2,875) and interest in repeat visits (p=0,000). Cost is the dominant factor with a risk of 5.8 times, followed by access and quality. There is a significant relationship between these three factors and interest in repeat visits. Priority recommendations are to improve access through integrated digital systems and flexible tariff schemes, as well as strengthen service quality through continuous surveys and empathic communication training.
The Role Of Stress, Resilience, And Social Support In Academic Burnout Among Medical Students : A Systematic Review Alya Chelsea; Arif Rachman; Agus Sutarman; Arfiyanti
Journal of Innovation Research and Knowledge Vol. 6 No. 3 (2026): Agustus 2026
Publisher : Bajang Institute

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Academic burnout has become an increasingly important mental health concern among medical students due to the demanding nature of medical education, characterized by intensive academic workloads, clinical responsibilities, and sustained psychological pressure. Understanding the psychological and environmental factors associated with academic burnout is essential for supporting students' well-being and academic success. This systematic review aimed to synthesize current evidence regarding the roles of academic stress, resilience, and social support in academic burnout among medical students. The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Literature searches were performed in PubMed, Scopus, ProQuest, and Google Scholar. A total of 1,358 records were initially identified, of which 10 studies met the predefined eligibility criteria and were included in the final narrative synthesis following the PRISMA 2020 selection process. The synthesized evidence consistently identified academic stress as the principal psychological risk factor associated with academic burnout, whereas resilience and social support emerged as the primary protective factors associated with lower burnout levels. Additional determinants, including personality traits, academic adaptability, anxiety, workload, psychological well-being, and life satisfaction, were also associated with academic burnout, indicating that burnout is influenced by multiple interacting psychological, academic, and environmental factors. Overall, the findings highlight that academic burnout among medical students is a multifactorial phenomenon, highlighting the importance of integrated psychological and institutional strategies that address both psychological risk factors and protective resources to support students' well-being and foster healthier learning environments in medical education. However, the findings should be interpreted with caution because most included studies employed cross-sectional designs and substantial methodological heterogeneity precluded quantitative meta-analysis
Co-Authors Agus Sutarman Alya Chelsea Anggun Nabila Arfiyanti Arfiyanti Arfiyanti Arya Duta Dharma Dinda Puspa Gaby Priscillia Putri Ilham Syahputro Jafar Elyas Mugi Wahidin Muhammad Zhafran Maulana Nabil Ramaseno Ni Made Ayu Widiyasih Nuzuludz Dzikra Prihati Pujowaskito Ruth Je Deborah Octavia Shalya Regita Susi Shorayasari